Death-associated protein kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:35, 4 June 2019) (edit) (undo)
 
(16 intermediate revisions not shown.)
Line 1: Line 1:
-
<StructureSection load='1jkl' size='400' side='right' caption='Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry [[1jkl]])' scene=''>
+
<StructureSection load='1jkl' size='350' side='right' caption='Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry [[1jkl]])' scene='51/517372/Cv/1'>
 +
__TOC__
 +
== Function ==
-
'''Death-associated protein kinase''' (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions. DAPK1 is a positive mediator of γ-interferon induced programmed cell death. DAPK2 is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival. DAPK3 or zipper-interacting protein kinase is involved in the regulation of apoptosis.
+
'''Death-associated protein kinase''' (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions.<ref>PMID:16756490</ref> <br />
-
+
* '''DAPK1''' is a positive mediator of γ-interferon induced programmed cell death. <br />
-
==3D structures of death-associated protein kinase==
+
* '''DAPK2''' is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival. <br />
 +
* '''DAPK3''' or zipper-interacting protein kinase is involved in the regulation of apoptosis. <br />
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
== Relevance ==
-
===Death-associated protein kinase 1===
+
DAPK expression is lost in many types of cancer. DAPK1 expression is elevated in brains of Alzheimer Disease patients and in epilepsy patients. DAPK1 inhibitors are tested as drugs for attenuating acute brain injury.
-
[[1ig1]], [[1jkk]], [[3f5g]], [[3f5u]] – hDAPK catalytic domain + cation + nucleotide – human<br />
+
== Structural highlights ==
-
[[3gu5]], [[3gu7]] - hDAPK catalytic domain (mutant) + cation + nucleotide<br />
+
-
[[3eh9]], [[1jkl]], [[3eha]], [[3zxt]] - hDAPK catalytic domain + nucleotide<br />
+
-
[[3dfc]], [[3gu4]], [[3gu6]], [[3gu8]], [[3gub]] - hDAPK catalytic domain (mutant) + nucleotide<br />
+
-
[[1jks]], [[1jkt]], [[1zws]], [[2w4k]], [[2xzs]], [[2y0a]], [[2y4p]] – hDAPK catalytic domain<br />
+
-
[[1wmk]], [[2a27]], [[3dgk]] - hDAPK catalytic domain (mutant) <br />
+
-
[[2xuu]], [[4b4l]] - hDAPK catalytic and autoinhibitory domains (mutant) <br />
+
-
[[1p4f]], [[1wvw]], [[1wvx]], [[1wvy]], [[2yak]] – hDAPK catalytic domain + inhibitor<br />
+
-
[[2x0g]] - hDAPK catalytic domain + calmodulin
+
-
===Death-associated protein kinase 2===
+
DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. <scene name='51/517372/Cv/3'>The ATP substrate is bound in a cleft between the two lobes</scene>. <ref>PMID:11573098</ref>
-
[[2a2a]], [[2w4j]] – hDAPK catalytic domain<br />
+
==3D structures of death-associated protein kinase==
-
[[1z9x]] - hDAPK catalytic domain (mutant) <br />
+
[[Death-associated protein kinase 3D structures]]
-
[[2cke]] - hDAPK catalytic domain + inhibitor<br />
+
-
[[2ya9]] – mDAPK catalytic and autoinhibitory domains – mouse<br />
+
-
[[2yaa]], [[2yab]] - mDAPK catalytic and autoinhibitory domains + nucleotide<br />
+
-
===Death-associated protein kinase 3===
+
</StructureSection>
-
 
+
-
[[1yrp]] - hDAPK catalytic domain<br />
+
-
[[2j90]], [[3bhy]], [[3bqr]] - hDAPK catalytic domain + inhibitor<br />
+
-
 
+
== References ==
-
</StructureSection>
+
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of human death-associated protein kinase 1 catalytic domain complex with ATP analog (PDB entry 1jkl)

Drag the structure with the mouse to rotate

References

  1. ↑ Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210. PMID:16756490 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142615
  2. ↑ Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M. Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat Struct Biol. 2001 Oct;8(10):899-907. PMID:11573098 doi:10.1038/nsb1001-899

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Death-associated_protein_kinase"
Personal tools