Death-associated protein kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. <scene name='51/517372/Cv/ | + | DAPK1 structure contains a small β sheet N-terminal lobe and a larger helix-rich C-terminal lobe. <scene name='51/517372/Cv/3'>The ATP substrate is bound in a cleft between the two lobes</scene>. <ref>PMID:11573098</ref> |
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| + | ==3D structures of death-associated protein kinase== | ||
| + | [[Death-associated protein kinase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
| - | ==3D structures of death-associated protein kinase== | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Death-associated protein kinase 1 | ||
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| - | **[[1ig1]], [[1jkk]], [[3f5g]], [[3f5u]] – hDAPK catalytic domain + cation + nucleotide – human<br /> | ||
| - | **[[3gu5]], [[3gu7]] - hDAPK catalytic domain (mutant) + Mg + nucleotide<br /> | ||
| - | **[[3eh9]], [[1jkl]], [[3eha]], [[3zxt]] - hDAPK catalytic domain + nucleotide<br /> | ||
| - | **[[3dfc]], [[3gu4]], [[3gu6]], [[3gu8]], [[3gub]] - hDAPK catalytic domain (mutant) + nucleotide<br /> | ||
| - | **[[1jks]], [[1jkt]], [[1zws]], [[2w4k]], [[2xzs]], [[2y0a]], [[2y4p]], [[4pf4]] – hDAPK catalytic domain<br /> | ||
| - | **[[4pf4]] - hDAPK catalytic domain + Mg<br /> | ||
| - | **[[1wmk]], [[2a27]], [[3dgk]], [[4uv0]] - hDAPK catalytic domain (mutant) <br /> | ||
| - | **[[2xuu]], [[4b4l]], [[4tl0]] - hDAPK catalytic and autoregulatory domains (mutant) <br /> | ||
| - | **[[1p4f]], [[1wvw]], [[1wvx]], [[1wvy]], [[2yak]], [[4txc]] – hDAPK catalytic domain + inhibitor<br /> | ||
| - | **[[4yo4]] – hDAPK catalytic domain + phthalazine<br /> | ||
| - | **[[4ypd]] – hDAPK catalytic domain + pyridazine<br /> | ||
| - | **[[5aut]], [[5auu]], [[5auv]], [[5auw]], [[5aux]], [[5auy]], [[5auz]], [[5av0]], [[5av1]], [[5av2]], [[5av3]], [[5av4]] – hDAPK catalytic domain + flavonoid<br /> | ||
| - | **[[2x0g]] - hDAPK catalytic domain + calmodulin | ||
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| - | *Death-associated protein kinase 2 | ||
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| - | **[[2a2a]], [[2w4j]] – hDAPK catalytic domain<br /> | ||
| - | **[[1z9x]] - hDAPK catalytic domain (mutant) <br /> | ||
| - | **[[2cke]] - hDAPK catalytic domain + inhibitor<br /> | ||
| - | **[[2ya9]] – mDAPK catalytic and autoinhibitory domains – mouse<br /> | ||
| - | **[[2yaa]], [[2yab]] - mDAPK catalytic and autoinhibitory domains + nucleotide<br /> | ||
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| - | *Death-associated protein kinase 3 | ||
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| - | **[[1yrp]], [[5a6o]] - hDAPK catalytic domain<br /> | ||
| - | **[[2j90]], [[3bhy]], [[3bqr]], [[5a6n]] - hDAPK catalytic domain + inhibitor<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Bialik S, Kimchi A. The death-associated protein kinases: structure, function, and beyond. Annu Rev Biochem. 2006;75:189-210. PMID:16756490 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142615
- ↑ Tereshko V, Teplova M, Brunzelle J, Watterson DM, Egli M. Crystal structures of the catalytic domain of human protein kinase associated with apoptosis and tumor suppression. Nat Struct Biol. 2001 Oct;8(10):899-907. PMID:11573098 doi:10.1038/nsb1001-899
