Deoxyuridine 5'-triphosphate nucleotidohydrolase
From Proteopedia
(Difference between revisions)
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The <scene name='48/488500/Cv/5'>active site</scene> contains Mg<sup>+2</sup> ions which are essensial for DUTP activity. The <scene name='48/488500/Cv/6'>Mg+2 ions are hexacoordinated to acidic residues and water molecules</scene>.<ref>PMID:15364583</ref> Water molecules are labeled Wa. | The <scene name='48/488500/Cv/5'>active site</scene> contains Mg<sup>+2</sup> ions which are essensial for DUTP activity. The <scene name='48/488500/Cv/6'>Mg+2 ions are hexacoordinated to acidic residues and water molecules</scene>.<ref>PMID:15364583</ref> Water molecules are labeled Wa. | ||
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| + | ==3D structures of dUTPase== | ||
| + | [[dUTPase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of dUTPase== | ==3D structures of dUTPase== | ||
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*DUTP | *DUTP | ||
| + | **[[1q5u]] - hDUTP – human<br /> | ||
**[[1dup]], [[1eu5]], [[1euw]] – EcDUTP – ''Escherichia coli''<br /> | **[[1dup]], [[1eu5]], [[1euw]] – EcDUTP – ''Escherichia coli''<br /> | ||
**[[1dun]] – EvDUTP – Equine infectious anemia virus<br /> | **[[1dun]] – EvDUTP – Equine infectious anemia virus<br /> | ||
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**[[2xx6]] - BsDUTP – ''Bacillus subtilis''<br /> | **[[2xx6]] - BsDUTP – ''Bacillus subtilis''<br /> | ||
**[[3tqz]] - DUTP – ''Coxiella burnetii''<br /> | **[[3tqz]] - DUTP – ''Coxiella burnetii''<br /> | ||
| - | **[[1q5u]] - hDUTP – human<br /> | ||
**[[4lhr]] - DUTP – ''Burkholderia thailandensis''<br /> | **[[4lhr]] - DUTP – ''Burkholderia thailandensis''<br /> | ||
**[[3h6x]] - DUTP – ''Streptococcus mutans''<br /> | **[[3h6x]] - DUTP – ''Streptococcus mutans''<br /> | ||
**[[5myf]] - SaDUTP – ''Staphylococcus aureus''<br /> | **[[5myf]] - SaDUTP – ''Staphylococcus aureus''<br /> | ||
**[[5myi]] - SaDUTP (mutant)<br /> | **[[5myi]] - SaDUTP (mutant)<br /> | ||
| + | **[[6mai]] - LpDUTP – ''Legionella pneumophila''<br /> | ||
*DUTP binary complexes | *DUTP binary complexes | ||
| + | **[[4mz5]], [[4mz6]] – hDUTP + importin subunit α-1<br /> | ||
| + | **[[5h4j]] - hDUTP + inhibitor<br /> | ||
**[[1dud]] – EcDUTP + dUDP<br /> | **[[1dud]] – EcDUTP + dUDP<br /> | ||
**[[2hrm]] - EcDUTP + dUTP derivative<br /> | **[[2hrm]] - EcDUTP + dUTP derivative<br /> | ||
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**[[3tq5]], [[3trl]], [[3trn]], [[3ts6]], [[3tsl]], [[3tta]] - MPmvDUTP catalytic domain (mutant) + dUMP<br /> | **[[3tq5]], [[3trl]], [[3trn]], [[3ts6]], [[3tsl]], [[3tta]] - MPmvDUTP catalytic domain (mutant) + dUMP<br /> | ||
**[[4ooq]], [[2pc5]] – AtDUTP + Mg – ''Arabidopsis thaliana''<br /> | **[[4ooq]], [[2pc5]] – AtDUTP + Mg – ''Arabidopsis thaliana''<br /> | ||
| - | **[[4mz5]], [[4mz6]] – hDUTP + importin subunit α-1<br /> | ||
| - | **[[5h4j]] - hDUTP + inhibitor<br /> | ||
**[[3zf0]], [[3zf1]], [[3zf2]], [[3zf3]], [[3zf4]], [[3zf5]], [[3zf6]], [[5cct]], [[5nyz]], [[5nz2]] - SpDUTP (mutant) + dUTP derivative – ''Staphylococcus'' phage 80α<br /> | **[[3zf0]], [[3zf1]], [[3zf2]], [[3zf3]], [[3zf4]], [[3zf5]], [[3zf6]], [[5cct]], [[5nyz]], [[5nz2]] - SpDUTP (mutant) + dUTP derivative – ''Staphylococcus'' phage 80α<br /> | ||
**[[5cco]] - SpDUTP + dUMP <br /> | **[[5cco]] - SpDUTP + dUMP <br /> | ||
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**[[4wrk]] - DUTP (mutant) + dUTP derivative – ''Staphylococcus'' phage φ11<br /> | **[[4wrk]] - DUTP (mutant) + dUTP derivative – ''Staphylococcus'' phage φ11<br /> | ||
**[[5myd]] - DUTP + dUTP derivative – ''Staphylococcus'' <br /> | **[[5myd]] - DUTP + dUTP derivative – ''Staphylococcus'' <br /> | ||
| + | **[[6mao]] - LpDUTP + dUMP <br /> | ||
*DUTP ternary complexes | *DUTP ternary complexes | ||
Revision as of 08:56, 5 June 2019
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3D structures of dUTPase
Updated on 05-June-2019
References
- ↑ Vertessy BG, Toth J. Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases. Acc Chem Res. 2009 Jan 20;42(1):97-106. PMID:18837522 doi:10.1021/ar800114w
- ↑ Moroz OV, Harkiolaki M, Galperin MY, Vagin AA, Gonzalez-Pacanowska D, Wilson KS. The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases. J Mol Biol. 2004 Oct 1;342(5):1583-97. PMID:15364583 doi:10.1016/j.jmb.2004.07.050
