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6e67

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'''Unreleased structure'''
 
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The entry 6e67 is ON HOLD until Paper Publication
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==Structure of beta2 adrenergic receptor fused to a Gs peptide==
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<StructureSection load='6e67' size='340' side='right'caption='[[6e67]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6e67]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6E67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6E67 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6e67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6e67 OCA], [http://pdbe.org/6e67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6e67 RCSB], [http://www.ebi.ac.uk/pdbsum/6e67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6e67 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ADRB2_HUMAN ADRB2_HUMAN]] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of the beta2-adrenergic receptor (beta2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (beta2AR-Gs(empty)). Unfortunately, the beta2AR-Gs(empty) complex does not provide a clear explanation for G protein coupling specificity. Evidence from several sources suggests the existence of a transient complex between the beta2AR and GDP-bound Gs protein (beta2AR-Gs(GDP)) that may represent an intermediate on the way to the formation of beta2AR-Gs(empty) and may contribute to coupling specificity. Here we present a structure of the beta2AR in complex with the carboxyl terminal 14 amino acids from Galphas along with the structure of the GDP-bound Gs heterotrimer. These structures provide evidence for an alternate interaction between the beta2AR and Gs that may represent an intermediate that contributes to Gs coupling specificity.
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Authors: Liu, X., Xu, X., Hilger, D., Tiemann, J., Liu, H., Du, Y., Hirata, K., Sun, X., Guixa-Gonzalez, R., Mathiesen, J., Hildebrand, P., Kobilka, B.
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Structural Insights into the Process of GPCR-G Protein Complex Formation.,Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK Cell. 2019 May 16;177(5):1243-1251.e12. doi: 10.1016/j.cell.2019.04.021. Epub, 2019 May 9. PMID:31080070<ref>PMID:31080070</ref>
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Description: Structure of beta2 adrenergic receptor fused to a Gs peptide
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Liu, X]]
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<div class="pdbe-citations 6e67" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Lysozyme]]
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[[Category: Du, Y]]
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[[Category: Guixa-Gonzalez, R]]
[[Category: Hildebrand, P]]
[[Category: Hildebrand, P]]
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[[Category: Liu, H]]
 
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[[Category: Sun, X]]
 
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[[Category: Mathiesen, J]]
 
[[Category: Hilger, D]]
[[Category: Hilger, D]]
[[Category: Hirata, K]]
[[Category: Hirata, K]]
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[[Category: Xu, X]]
 
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[[Category: Du, Y]]
 
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[[Category: Guixa-Gonzalez, R]]
 
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[[Category: Tiemann, J]]
 
[[Category: Kobilka, B]]
[[Category: Kobilka, B]]
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[[Category: Liu, H]]
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[[Category: Liu, X]]
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[[Category: Mathiesen, J]]
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[[Category: Sun, X]]
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[[Category: Tiemann, J]]
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[[Category: Xu, X]]
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[[Category: G protein coupled receptor]]
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[[Category: Membrane protein]]

Revision as of 22:42, 5 June 2019

Structure of beta2 adrenergic receptor fused to a Gs peptide

PDB ID 6e67

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