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5lp1
From Proteopedia
(Difference between revisions)
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==CRYSTAL STRUCTURE OF HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 IN COMPLEX WITH A [1.1.1]BICYCLOPENTANE-CONTAINING INHIBITOR AT 1.91A RESOLUTION.== | ==CRYSTAL STRUCTURE OF HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 IN COMPLEX WITH A [1.1.1]BICYCLOPENTANE-CONTAINING INHIBITOR AT 1.91A RESOLUTION.== | ||
| - | <StructureSection load='5lp1' size='340' side='right' caption='[[5lp1]], [[Resolution|resolution]] 1.91Å' scene=''> | + | <StructureSection load='5lp1' size='340' side='right'caption='[[5lp1]], [[Resolution|resolution]] 1.91Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5lp1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LP1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5lp1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LP1 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71H:~{N}-[2-(DIETHYLAMINO)ETHYL]-2-[2-[(4-FLUOROPHENYL)METHYLSULFANYL]-4-OXIDANYLIDENE-5~{H}-CYCLOPENTA[D]PYRIMIDIN-1-YL]-~{N}-[[3-[4-(TRIFLUOROMETHYL)PHENYL]-1-BICYCLO[1.1.1]PENTANYL]METHYL]ETHANAMIDE'>71H</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=71H:~{N}-[2-(DIETHYLAMINO)ETHYL]-2-[2-[(4-FLUOROPHENYL)METHYLSULFANYL]-4-OXIDANYLIDENE-5~{H}-CYCLOPENTA[D]PYRIMIDIN-1-YL]-~{N}-[[3-[4-(TRIFLUOROMETHYL)PHENYL]-1-BICYCLO[1.1.1]PENTANYL]METHYL]ETHANAMIDE'>71H</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G7, PAFAH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase 1-alkyl-2-acetylglycerophosphocholine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.47 3.1.1.47] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-alkyl-2-acetylglycerophosphocholine_esterase 1-alkyl-2-acetylglycerophosphocholine esterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.47 3.1.1.47] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lp1 OCA], [http://pdbe.org/5lp1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lp1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lp1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lp1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lp1 OCA], [http://pdbe.org/5lp1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lp1 RCSB], [http://www.ebi.ac.uk/pdbsum/5lp1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lp1 ProSAT]</span></td></tr> | ||
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</div> | </div> | ||
<div class="pdbe-citations 5lp1" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5lp1" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Phospholipase A2|Phospholipase A2]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]] | [[Category: 1-alkyl-2-acetylglycerophosphocholine esterase]] | ||
| - | [[Category: | + | [[Category: Human]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Somers, D]] | ||
[[Category: Alpha/beta-hydrolase-fold]] | [[Category: Alpha/beta-hydrolase-fold]] | ||
[[Category: Glycoprotein]] | [[Category: Glycoprotein]] | ||
Revision as of 06:01, 12 June 2019
CRYSTAL STRUCTURE OF HUMAN LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 IN COMPLEX WITH A [1.1.1]BICYCLOPENTANE-CONTAINING INHIBITOR AT 1.91A RESOLUTION.
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Categories: 1-alkyl-2-acetylglycerophosphocholine esterase | Human | Large Structures | Somers, D | Alpha/beta-hydrolase-fold | Glycoprotein | Group viia pla2 | Hydrolase | Hydrolase-hydrolase inhibitor complex | Ldl-bound | Lipid degradation | Lipoprotein associated phospholipase a2 | Lp-pla2 | Plasma platelet-activating factor acetylhydrolase | Polymorphism | Secreted | Secreted protein
