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DNA methyltransferase

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The <scene name='46/467277/Cv/8'>active site of methyladenine DNMT contains the methyl donor SAM</scene>.
The <scene name='46/467277/Cv/8'>active site of methyladenine DNMT contains the methyl donor SAM</scene>.
 +
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== 3D Structures of DNA methyltransferase ==
 +
[[DNA methyltransferase 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of DNA methyltransferase ==
== 3D Structures of DNA methyltransferase ==
Line 54: Line 58:
*Methylcytosine DNMT
*Methylcytosine DNMT
-
**[[2qrv]] - h-cytosine DNMT
+
**[[3epz]] - h-cytosine DNMT 1 replication foci-targeting sequence
-
 
+
**[[4yoc]] - h-cytosine DNMT 1 residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br />
-
**[[3epz]] - h-cytosine DNMT replecation foci-targeting sequence
+
**[[4z97]], [[4z96]] - h-cytosine DNMT 1 residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br />
-
 
+
**[[5ydr]] - h-cytosine DNMT 1 RFTS domain residues 351-599 + ubiquitin<br />
-
**[[3flg]] - h-cytosine DNMT ADD domain
+
**[[5wvo]] - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1<br />
-
 
+
**[[4wxx]] - h-cytosine DNMT 1 residues 351-1600 + SAH<br />
-
**[[3a1a]] - h-cytosine DNMT PWWP domain
+
**[[1g55]] - h-cytosine DNMT 2 (mutant)<br />
-
 
+
**[[2qrv]] - h-cytosine DNMT 3A C-terminal domain<br />
-
**[[1g55]] - h-cytosine DNMT2 (mutant)<br />
+
**[[3a1a]] - h-cytosine DNMT 3A ADD domain<br />
-
**[[3qkj]] - h-cytosine DNMT 3β<br />
+
**[[3a1b]], [[4qbq]] - h-cytosine DNMT 3A ADD domain + histone H3<br />
-
 
+
**[[4qbr]], [[4qbs]] - h-cytosine DNMT 3A ADD domain (mutant) + histone H3<br />
-
**[[2uyc]], [[2uyh]], [[2uz4]] - Hh-cytosine DNMT (mutant) + DNA + SAH
+
-
 
+
-
**[[3a1b]], [[4qbq]] - h-cytosine DNMT ADD domain + histone H3<br />
+
-
**[[4qbr]], [[4qbs]] - h-cytosine DNMT ADD domain (mutant) + histone H3<br />
+
-
**[[5ciu]] - h-cytosine DNMT residues 206-355 + histone H3.2<br />
+
-
**[[4yoc]] - h-cytosine DNMT residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7<br />
+
-
**[[4z97]], [[4z96]] - h-cytosine DNMT residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7<br />
+
-
**[[5ydr]] - h-cytosine DNMT RFTS domain residues 351-599 + ubiquitin<br />
+
-
**[[5wvo]] - h-cytosine DNMT RFTS domain + ubiquitin + histone H3.1<br />
+
-
**[[4wxx]] - h-cytosine DNMT residues 351-1600 + SAH<br />
+
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
-
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
 
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
 +
**[[6f57]], [[5yx2]], [[6brr]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
 +
**[[3flg]] - h-cytosine DNMT 3B PWWP domain<br />
 +
**[[3qkj]] - h-cytosine DNMT 3B residues 293-442<br />
 +
**[[5nvo]] - h-cytosine DNMT 3B PWWP domain + choline<br />
 +
**[[5nv7]], [[5nv2]], [[5nv0]], [[5nrv]], [[5nrs]], [[5nrr]], [[5nr3]] - h-cytosine DNMT 3B PWWP domain + inhibitor<br />
 +
**[[5ciu]] - h-cytosine DNMT 3B residues 206-355 + histone H3.2<br />
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br />
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br />
**[[5wy1]] - m-cytosine DNMT (mutant) <br />
**[[5wy1]] - m-cytosine DNMT (mutant) <br />

Revision as of 08:38, 12 June 2019

Adenine DNMT complex with SAM and Cl- ion (PDB code 1nw5).

Drag the structure with the mouse to rotate

3D Structures of DNA methyltransferase

Updated on 12-June-2019

References

  1. ↑ Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
  2. ↑ Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
  3. ↑ Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
  4. ↑ Sankpal UT, Rao DN. Structure, function, and mechanism of HhaI DNA methyltransferases. Crit Rev Biochem Mol Biol. 2002;37(3):167-97. PMID:12139442 doi:http://dx.doi.org/10.1080/10409230290771492

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