Elastase

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<StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code [[1eai]]).' scene='41/411401/Cv/3'>
<StructureSection load='1eai' size='350' side='right' caption='Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code [[1eai]]).' scene='41/411401/Cv/3'>
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[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see [[Serine Proteases]].
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[[Elastase]] (ELA) is a chymotrypsin-like serine protease which breaks down proteins. The ELAs are numbered according to their genes. '''Panceatic ELA''' cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. <ref>PMID:12059069</ref> For additional details see <br />
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*[[Protease]]<br />
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*[[Serine Proteases]].
== Relevance ==
== Relevance ==
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'''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
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'''ELA1''' in the pancreas correlates well with exocrine pancreatic functioning and is used as a function test for patients with pancreatitis. '''ELA2''' (or PMN-ELA) is secreted by neutrophils during inflammation.
== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='41/411401/Cv/6'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/5'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/7'>catalytic triad is Ser-His-Asp</scene>.
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<scene name='41/411401/Cv/8'>Pig elastase</scene> (cyan, green) complex with <scene name='41/411401/Cv/9'>chymotrypsin/elastase isoinhibitor</scene> (magenta, yellow) (PDB code [[1eai]]). ELA <scene name='41/411401/Cv/10'>catalytic triad is Ser-His-Asp</scene>.<ref>PMID:7922044</ref>
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</StructureSection>
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==3D structures of elastase==
==3D structures of elastase==
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[[Elastase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* MMP12 See [[Matrix metalloproteinase]]
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* MMP16 See [[Matrix metalloproteinase]]
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* ELA1
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**[[3mty]], [[3mu0]], [[3mu1]], [[3mu4]], [[3mu5]], [[3mu8]], [[3mnb]], [[3mnc]], [[3mns]], [[3mnx]], [[3mo3]], [[3mo6]], [[3mo9]], [[3moc]], [[3e3t]], [[2v0b]], [[2g4t]], [[2g4u]], [[2de8]], [[2blo]], [[2blq]], [[2a7c]], [[2a7j]], [[1gvk]], [[1qnj]], [[1lvy]], [[3est]], [[1est]], [[2oqu]], [[3odd]], [[3odf]], [[2bdc]] – pELA1 – pig<br />
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**[[3hgn]] – pELA1+peptidyl inhibitor – neutron<br />
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**[[3hgp]], [[2cv3]], [[2bdb]], [[2bcd]], [[2h1u]], [[1mmj]], [[1h9l]], [[1nes]], [[4est]], [[5est]], [[8est]], [[7est]], [[6est]] - pELA1+peptidyl inhibitor<br />
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**[[1fzz]] – pELA1+ONO-6818<br />
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**[[1qr3]], [[1qgf]], [[1bru]], [[1hv7]], [[1btu]] – pELA1+cyclic inhibitor<br />
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**[[1okx]] – pELA1 + scyptolin<br />
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**[[1e34]], [[1e35]], [[1e36]], [[1e37]], [[1e38]] – pELA1-gamma-lactam<br />
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**[[1eai]] – pELA1+Ascaris inhibitor<br />
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**[[2d26]] – pELA1+α-1-antitrypsin<br />
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**[[1fle]] – pELA1+elafin<br />
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**[[1b0e]], [[1b0f]] – pELA1+MDL<br />
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**[[2v35]] – pELA1+JM54<br />
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**[[2iot]] – pELA1+clavulanic acid<br />
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**[[2de9]] – pELA1+tris<br />
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**[[1uvo]], [[1uvp]], [[1lka]], [[1lkb]] – pELA1+ions<br />
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**[[1gwa]] – pELA1+I3<br />
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**[[1uo6]], [[1c1m]] – pELA1+Xe<br />
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**[[1l0z]], [[1l1g]] - pELA1+Xe+Br<br />
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**[[2bb4]], [[2bd2]], [[2bd3]], [[2bd4]], [[2bd5]], [[2bd7]], [[2bd8]], [[2bd9]], [[1hax]], [[1hay]], [[1haz]], [[1hb0]], [[1qix]] – pELA1+beta-casomorphin-7<br />
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**[[2bda]] – pELA1+N-acetyl-NPI<br />
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**[[1mcv]] – pELA1+squash inhibitor<br />
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**[[1bma]] – pELA1+aminimide<br />
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**[[1elf]], [[1elg]] – pELA1+peptidyl hydroxylamine<br />
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**[[1eld]], [[1ele]], [[1elb]], [[1ela]], [[1elc]], [[2est]] – pELA1+anilide inhibitor<br />
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**[[1esa]], [[1esb]] – pELA1 intermediate<br />
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**[[1eas]], [[1eat]], [[1eau]] – pELA1+pyridine inhibitor<br />
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**[[1inc]] – pELA1+benzoxazinone<br />
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**[[1jim]], [[9est]], [[8est]] – pELA1+coumarin derivative<br />
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**[[2fo9]], [[2foa]], [[2fob]], [[2foc]], [[2fod]], [[2foe]], [[2fof]], [[2fog]], [[2foh]] – pELA1+solvent<br />
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**[[4k89]] – PaELA – ''Pseudomonas aeruginosa''<br />
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**[[3dbk]] – PaELA+phophoramidon <br />
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**[[1u4g]] – PaELA+HPI<br />
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**[[1ezm]] - PaELA<br />
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**[[1elt]] – ELA - salmon<br />
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* ELA2
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**[[3q76]] – hELA2<br />
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**[[3q77]] – hELA2+dihydropyrimidone inhibitor<br />
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**[[2z7f]] – hELA2 peptidase domain +antileukoproteinase<br />
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**[[2rg3]] – hELA2+sulfonic inhibitor<br />
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**[[1h1b]], [[1ppg]], [[1hne]] – hELA2+inhibitor<br />
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**[[1ppf]] – hELA2+ovomucoid<br />
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**[[1b0f]] – hELA2+MDL101146<br />
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**[[4nzl]] – hELA2 + protein <br />
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**[[4wvp]] – hELA2 + activity-based probe <br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pig elastase (cyan, green) complex with chymotrypsin/elastase isoinhibitor (magenta, yellow) (PDB code 1eai).

Drag the structure with the mouse to rotate

References

  1. ↑ Dominici R, Franzini C. Fecal elastase-1 as a test for pancreatic function: a review. Clin Chem Lab Med. 2002 Apr;40(4):325-32. PMID:12059069 doi:http://dx.doi.org/10.1515/CCLM.2002.051
  2. ↑ Huang K, Strynadka NC, Bernard VD, Peanasky RJ, James MN. The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase. Structure. 1994 Jul 15;2(7):679-89. PMID:7922044

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Guido Hansen, Jaime Prilusky

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