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6gr2

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(New page: '''Unreleased structure''' The entry 6gr2 is ON HOLD Authors: Bezerra, G.A., Mackinnon, S., Williams, E., Zhang, M., Arrowsmith, C., Edwards, A., Bountra, C., Lai, K., Yue, W.W., Struct...)
Current revision (05:54, 19 June 2019) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6gr2 is ON HOLD
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==Structure of human galactokinase in complex with galactose and ADP==
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<StructureSection load='6gr2' size='340' side='right'caption='[[6gr2]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
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Authors: Bezerra, G.A., Mackinnon, S., Williams, E., Zhang, M., Arrowsmith, C., Edwards, A., Bountra, C., Lai, K., Yue, W.W., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6gr2]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GR2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GR2 FirstGlance]. <br>
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Description: Structure of human galactokinase in complex with galactose and ADP
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1wuu|1wuu]]</td></tr>
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[[Category: Zhang, M]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Galactokinase Galactokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.6 2.7.1.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gr2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gr2 OCA], [http://pdbe.org/6gr2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gr2 RCSB], [http://www.ebi.ac.uk/pdbsum/6gr2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gr2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN]] Defects in GALK1 are the cause of galactosemia II (GALCT2) [MIM:[http://omim.org/entry/230200 230200]]. Galactosemia II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.<ref>PMID:10521295</ref> <ref>PMID:10790206</ref> <ref>PMID:11231902</ref> <ref>PMID:11139256</ref> <ref>PMID:12694189</ref> <ref>PMID:15024738</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/GALK1_HUMAN GALK1_HUMAN]] Major enzyme for galactose metabolism.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Galactokinase]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Bezerra, G A]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A]]
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[[Category: Lai, K]]
[[Category: Mackinnon, S]]
[[Category: Mackinnon, S]]
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[[Category: Lai, K]]
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[[Category: Structural genomic]]
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[[Category: Bezerra, G.A]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Edwards, A]]
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[[Category: Williams, E]]
[[Category: Williams, E]]
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[[Category: Yue, W.W]]
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[[Category: Yue, W W]]
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[[Category: Bountra, C]]
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[[Category: Zhang, M]]
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[[Category: Arrowsmith, C]]
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[[Category: Adp]]
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[[Category: Galactose]]
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[[Category: Ghmp kinase]]
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[[Category: Leloir pathway]]
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[[Category: Sgc]]
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[[Category: Transferase]]

Current revision

Structure of human galactokinase in complex with galactose and ADP

PDB ID 6gr2

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