Elongation factor

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<scene name='51/517376/Cv/4'>Complex EF-Tu with EF-Ts is heterotetramer</scene>, or, more exactly <scene name='51/517376/Cv/5'>heterodimer of homodimers</scene> (PDB entry [[1efu]]).<ref>PMID:8596629</ref>
<scene name='51/517376/Cv/4'>Complex EF-Tu with EF-Ts is heterotetramer</scene>, or, more exactly <scene name='51/517376/Cv/5'>heterodimer of homodimers</scene> (PDB entry [[1efu]]).<ref>PMID:8596629</ref>
 +
 +
==3D structures of elongation factor==
 +
[[Elongation factor 3D structures]]
</StructureSection>
</StructureSection>
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**[[3wxm]] – ApEF + plethora protein – ''Aeropyrum pernix''<br />
**[[3wxm]] – ApEF + plethora protein – ''Aeropyrum pernix''<br />
**[[4h9g]], [[4lbv]], [[4lbw]], [[4lby]], [[4lbz]], [[4lc0]] – TtEF – ''Thermus thermophilus''<br />
**[[4h9g]], [[4lbv]], [[4lbw]], [[4lby]], [[4lbz]], [[4lc0]] – TtEF – ''Thermus thermophilus''<br />
-
**[[4j0q]] – EF – ''Pseudomonas putida''<br />
+
**[[4j0q]] – PpEF – ''Pseudomonas putida''<br />
**[[5w75]] – EF – ''Thermotoga neapolitana''<br />
**[[5w75]] – EF – ''Thermotoga neapolitana''<br />
 +
**[[5tbf]] – EF domain 2-3– ''Vibrio cholerae''<br />
*''EF-Tu complex with antibiotics''
*''EF-Tu complex with antibiotics''
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*''EF-Tu complex with nucleotide''
*''EF-Tu complex with nucleotide''
-
**[[1efu]] – EcEF + GDP<BR />
+
**[[6eze]] – EcEF + GDP derivative<BR />
 +
**[[5opd]] – EcEF + GTP <BR />
**[[1exm]] – TtEF + GTP analog<br />
**[[1exm]] – TtEF + GTP analog<br />
**[[1eft]] – TaEF + GNP – ''Thermus aquaticus''<BR />
**[[1eft]] – TaEF + GNP – ''Thermus aquaticus''<BR />
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**[[1jny]], [[1skq]] – SsEF + GDP – ''Sulfolobus solfataricus''<br />
**[[1jny]], [[1skq]] – SsEF + GDP – ''Sulfolobus solfataricus''<br />
**[[3wya]] – PhEF + GDP - ''Pyrococcus horikoshii''<br />
**[[3wya]] – PhEF + GDP - ''Pyrococcus horikoshii''<br />
 +
**[[6mij]] – AbEF + GDP – ''Acinetobacter baumannii''<br />
 +
**[[6gfu]] – EF + GDP – synthetic<br />
*''EF-Tu complex with protein''
*''EF-Tu complex with protein''
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**[[5vh6]] – EF N terminal – ''Bacillus subtilis''<br />
**[[5vh6]] – EF N terminal – ''Bacillus subtilis''<br />
**[[6b8d]] – EF N terminal – ''Haemophilus influenzae''<br />
**[[6b8d]] – EF N terminal – ''Haemophilus influenzae''<br />
 +
**[[6not]] – EF – ''Rickettsia prowazekii''<br />
 +
**[[6bk7]] – EF N terminal – ''Enterococcus faecalis''<br />
 +
**[[6n0i]] – PpEF 2<br />
*''EF-G in the ribosome''
*''EF-G in the ribosome''
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**[[4v6a]] – TtEF in 70S ribosome<BR />
**[[4v6a]] – TtEF in 70S ribosome<BR />
**[[3oyy]] – PaEF <BR />
**[[3oyy]] – PaEF <BR />
 +
**[[6j7m]] – PaEF + EARP<br />
**[[3tre]] – EF – ''Coxiella burnetii''<br />
**[[3tre]] – EF – ''Coxiella burnetii''<br />
**[[3a5z]] – EcEF + lysyl-tRNA synthetase<br />
**[[3a5z]] – EcEF + lysyl-tRNA synthetase<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
-
**[[5j3b]] – EF – ''Acinetobacter baumannii''<br />
+
**[[5j3b]] – AbEF <br />
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
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*EF-1
*EF-1
-
**[[4c0s]] – rEF α-2 – rabbit<br />
 
**[[5dqs]] – hEF β+γ <br />
**[[5dqs]] – hEF β+γ <br />
**[[5jpo]] – hEF γ+δ <br />
**[[5jpo]] – hEF γ+δ <br />
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
 +
**[[5bmu]] – hEF ε-1 + Glu tRNA ligase <br />
 +
**[[5y6l]] – hEF ε-1 (mutant) + MetRS + AspRS + Glu/Pro tRNA ligase + P38<br />
 +
**[[4c0s]] – rEF α-2 – rabbit<br />
**[[5o8w]] – yEF α+β <br />
**[[5o8w]] – yEF α+β <br />
**[[1nhy]] – yEF γ N terminal<br />
**[[1nhy]] – yEF γ N terminal<br />
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*EF-Spt5
*EF-Spt5
 +
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
 +
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
 +
**[[6eqy]] – hEF KOW4 motif residues 522-647 – NMR<BR />
 +
**[[2e70]] – hEF KOW5 motif residues 694-757 – NMR<BR />
 +
**[[6er0]] – hEF KOW6 motif residues 961-1087 – NMR<BR />
**[[2do3]], [[2e6z]], [[2e70]] – hEF KOW motif residues 694-757 – NMR<BR />
**[[2do3]], [[2e6z]], [[2e70]] – hEF KOW motif residues 694-757 – NMR<BR />
**[[5ohq]] – hEF KOW6-KOW7 domain residues 939-1087<br />
**[[5ohq]] – hEF KOW6-KOW7 domain residues 939-1087<br />
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*EF-Spt16
*EF-Spt16
-
**[[5umu]], [[5umt]] – hEF<br />
+
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5e5b]] - hEF N-terminal<BR />
**[[5e5b]] - hEF N-terminal<BR />
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**[[4hfx]] – hEloA F-box domain<br />
**[[4hfx]] – hEloA F-box domain<br />
 +
 +
*Elongin C
 +
 +
**[[5zb2]] – yEloC + Rad7<br />
 +
**[[1hv2]] - yEloC + von-Hippel Lindau disease tumor suppressor - NMR <br />
*Elongin BC complex
*Elongin BC complex
**[[1lqb]], [[1lm8]] – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 1 α<br />
**[[1lqb]], [[1lm8]] – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 1 α<br />
-
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[6fmi]], [[6fmj]], [[6fmk]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]] - hEloBC + von-Hippel Lindau disease tumor suppressor + inhibitor<br />
+
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[6fmi]], [[6fmj]], [[6fmk]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[6gfy]] - hEloBC + von-Hippel Lindau disease tumor suppressor + inhibitor<br />
**[[5t35]] - hEloBC + von-Hippel Lindau disease tumor suppressor + BRD4<br />
**[[5t35]] - hEloBC + von-Hippel Lindau disease tumor suppressor + BRD4<br />
**[[4wqo]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 <br />
**[[4wqo]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 <br />
 +
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + von-Hippel Lindau disease tumor suppressor + transcription activator <br />
 +
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor peptide <br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
-
**[[3zrf]], [[5lli]] - hEloBC + von-Hippel Lindau disease tumor suppressor<br />
+
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + von-Hippel Lindau disease tumor suppressor<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[6c5x]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
**[[6c5x]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
 +
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
 +
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[3dcg]] – hEloBC + virion infectivity factor<br />
**[[3dcg]] – hEloBC + virion infectivity factor<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />

Revision as of 08:27, 19 June 2019

Structure of EF-Tu (cyan and magenta) with EF-Ts (green and yellow) (PDB entry 1efu)

Drag the structure with the mouse to rotate

3D structures of elongation factor

Updated on 19-June-2019


References

  1. ↑ Takeshita D, Tomita K. Assembly of Q{beta} viral RNA polymerase with host translational elongation factors EF-Tu and -Ts. Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15733-8. Epub 2010 Aug 23. PMID:20798060 doi:http://dx.doi.org/10.1073/pnas.1006559107
  2. ↑ Jorgensen R, Merrill AR, Andersen GR. The life and death of translation elongation factor 2. Biochem Soc Trans. 2006 Feb;34(Pt 1):1-6. PMID:16246167 doi:http://dx.doi.org/10.1042/BST20060001
  3. ↑ Aso T, Lane WS, Conaway JW, Conaway RC. Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II. Science. 1995 Sep 8;269(5229):1439-43. PMID:7660129
  4. ↑ Kawashima T, Berthet-Colominas C, Wulff M, Cusack S, Leberman R. The structure of the Escherichia coli EF-Tu.EF-Ts complex at 2.5 A resolution. Nature. 1996 Feb 8;379(6565):511-8. PMID:8596629 doi:http://dx.doi.org/10.1038/379511a0

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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