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6o13

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'''Unreleased structure'''
 
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The entry 6o13 is ON HOLD until Paper Publication
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==E. coli cysteine desulfurase SufS H123A with a Cys-ketimine intermediate==
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<StructureSection load='6o13' size='340' side='right'caption='[[6o13]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6o13]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6O13 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6O13 FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CKT:Cys-ketimine'>CKT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6o13 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6o13 OCA], [http://pdbe.org/6o13 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6o13 RCSB], [http://www.ebi.ac.uk/pdbsum/6o13 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6o13 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SUFS_ECOLI SUFS_ECOLI]] Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo.<ref>PMID:10829016</ref> <ref>PMID:12089140</ref> <ref>PMID:11997471</ref> <ref>PMID:12876288</ref> <ref>PMID:12941942</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Dunkle, J A]]
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[[Category: Frantom, P A]]
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[[Category: Cysteine desulfurase]]
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[[Category: Lyase]]
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[[Category: Persulfide]]
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[[Category: Plp]]
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[[Category: Suf]]
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[[Category: Transferase]]

Revision as of 05:56, 3 July 2019

E. coli cysteine desulfurase SufS H123A with a Cys-ketimine intermediate

PDB ID 6o13

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