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6r3c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6r3c is ON HOLD Authors: Schweimer, K. Description: Solution structure of birch pollen allergen Bet v 1a Category: Unreleased Structures [[Cate...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of birch pollen allergen Bet v 1a== | |
| + | <StructureSection load='6r3c' size='340' side='right'caption='[[6r3c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6r3c]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R3C FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r3c OCA], [http://pdbe.org/6r3c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r3c RCSB], [http://www.ebi.ac.uk/pdbsum/6r3c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r3c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BEV1A_BETPN BEV1A_BETPN]] May be a general steroid carrier protein (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Hazelnut is one of the most frequent causes of food allergy. The major hazel allergen in Northern Europe is Cor a 1, which is homologous to the major birch pollen allergen Bet v 1. Both allergens belong to the pathogenesis related class PR-10. We determined the solution structure of Cor a 1.0401 from hazelnut and identified a natural ligand of the protein. The structure reveals the protein fold characteristic for PR-10 family members, which consists of a seven-stranded antiparallel beta-sheet, two short alpha-helices arranged in V-shape and a long C-terminal alpha-helix encompassing a hydrophobic pocket. However, despite the structural similarities between Cor a 1 and Bet v 1, they bind different ligands. We have shown previously that Bet v 1 binds to quercetin-3-O-sophoroside. Here, we isolated Cor a 1 from hazel pollen and identified the bound ligand, quercetin-3-O-(2"-O-beta-D-glucopyranosyl)-beta-D-galactopyranoside, by mass spectrometry and nuclear magnetic resonance spectroscopy (NMR). NMR experiments were performed to confirm binding. Remarkably, although it has been shown that PR-10 allergens show promiscuous binding behaviour in vitro, we can demonstrate that Cor a 1.0401 and Bet v 1.0101 exhibit highly selective binding for their specific ligand but not for the respective ligand of the other allergen. | ||
| - | + | Identification of a natural ligand of the hazel allergen Cor a 1.,Jacob T, von Loetzen CS, Reuter A, Lacher U, Schiller D, Schobert R, Mahler V, Vieths S, Rosch P, Schweimer K, Wohrl BM Sci Rep. 2019 Jun 18;9(1):8714. doi: 10.1038/s41598-019-44999-2. PMID:31213622<ref>PMID:31213622</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6r3c" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Schweimer, K]] | [[Category: Schweimer, K]] | ||
| + | [[Category: Allergen]] | ||
| + | [[Category: Bet v 1]] | ||
| + | [[Category: Birch pollen allergen]] | ||
Current revision
Solution structure of birch pollen allergen Bet v 1a
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