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| - | [[Image:2bmv.png|left|200px|thumb|Crystal Structure of Flavodoxin, [[2bmv]]]]
| + | <StructureSection load='2bmv' size='350' side='right' scene='41/413119/Cv/2' caption='Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion (PDB code [[2bmv]]) '> |
| - | {{STRUCTURE_2bmv| PDB=2bmv | SIZE=300| SCENE=Flavodoxin/Cv/1 |right|CAPTION=Apo-Flavodoxin from ''Helicobacter pylori'' complexed with benzamidine and chloride ion, [[2bmv]] }}
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| - | [[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N2 to NH3 while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red. '''NrdI''' is a FDX which is involved in ribonucleotide reduction. '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX. In ''E. coli'' there are 2 distinct FDX I and II. The images at the left and at the right correspond to one representative FDX structure, ''i.e.'' the crystal structure of apo-flavodoxin from ''Helicobacter pylori'' ([[2bmv]]). The space filling objects are of chloride ion and benzamidine. | + | [[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N<sub>2</sub> to NH<sub>3</sub> while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red<ref>PMID:9416602</ref>. '''NrdI''' is a FDX which is involved in ribonucleotide reduction. '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX. In ''E. coli'' there are 2 distinct flavodoxins: FDX I and II. |
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| - | {{TOC limit|limit=2}}
| + | *<scene name='41/413119/Cv/5'>Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion</scene>. |
| | + | *<scene name='41/413119/Cv/6'>Cl coordination site</scene>. Water molecules shown as red spheres. |
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| | == 3D Structures of Flavodoxin == | | == 3D Structures of Flavodoxin == |
| | + | [[Flavodoxin 3D structures]] |
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| + | </StructureSection> |
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| - | === Apo FDX === | + | == References == |
| - | | + | <references/> |
| - | [[2kqu]], [[1dx9]] – AnFDX (mutant) apo – ''Anabanea'' – NMR<br />
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| - | [[2bmv]] – HpFDX apo - ''Helicobacter pylori''<br />
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| - | [[3d7n]] – FDX apo – ''Agrobacterium tumefaciens''<br />
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| - | [[2rg1]] - EcFDX WrbA apo - ''Escherichia coli''<br />
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| - | [[2hna]], [[2hnb]] – EcFDX apo – NMR<br />
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| - | [[1qhe]], [[1ftg]] – nFDX apo – Nostoc<br />
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| - | [[1bu5]] – DvFDX apo+riboflavin - ''Desulfovibrio vulgaris''<br />
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| - | | + | |
| - | === FDX containing FMN oxidized (quinone) ===
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| - | | + | |
| - | [[3f6r]], [[3f6s]], [[3kap]] – DdFDX-ox - ''Desulfovibrio desulfuricans''<br />
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| - | [[4heq]] - FDX-ox – ''Desulfovibrio gigas'' <br />
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| - | [[1ag9]] – EcFDX-ox<br />
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| - | [[1flv]] – nFDX-ox<br />
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| - | [[1xyy]], [[1j9g]], [[1c7f]], [[1akr]], [[1akt]], [[1akw]] – DvFDX-ox (mutant)<br />
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| - | [[2fx2]], [[3fx2]], [[4fx2]], [[5fx2]], [[1fx1]] – DvFDX-ox<br />
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| - | [[1czk]], [[1czr]] – SeFDX-ox (mutant) - ''Synechococcus elongates''<br />
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| - | [[1czn]] – SeFDX-ox I<br />
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| - | [[1ofv]] – SeFDX-ox II<br />
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| - | [[1czu]], [[1d03]] - SeFDX-ox II<br />
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| - | [[2fdx]], [[1fld]], [[1fvx]], [[2fax]], [[3nll]], [[4nll]], [[4nul]], [[5nll]] – CbFDX-ox (mutant) - ''Clostridium beijerinckii''<br />
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| - | [[2fcr]] – FDX-ox – ''Chondrus crispus''<br />
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| - | [[1fue]] – HpFDX-ox<br />
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| - | [[4j8p]] - FDX-ox – ''Bacterioides uniformis'' <br />
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| - | | + | |
| - | === FDX containing FMNH (semiquinone) ===
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| - | | + | |
| - | [[2x2o]], [[2x2p]] – NrdI-sq – ''Bacillus cereus''<br />
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| - | [[3kaq]], [[3f90]] – DdFDX-sq <br />
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| - | [[1xt6]], [[1wsw]], [[1xyv]], [[1akv]], [[1wsb]] - DvFDX-sq (mutant)<br />
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| - | [[1czh]], [[1czl]] - SeFDX-sq (mutant)<br />
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| - | [[2fox]], [[5nul]]– CbFDX-sq<br />
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| - | | + | |
| - | === FDX containing FMNH2 (hydroquinone) ===
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| - | | + | |
| - | [[2fz5]] – FDX-red – ''Megasphaera elsdenii'' – NMR<br />
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| - | [[1c7e]], [[1aku]], [[1akq]] - DvFDX-red (mutant)<br />
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| - | [[1czo]] - SeFDX-red (mutant)<br />
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| - | [[1d04]] – SeFDX-red<br />
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| - | [[1fla]], [[1fln]], [[2flv]], [[2fvx]], [[5ull]], [[6nul]] – CbFDX-red (mutant)<br />
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| - | | + | |
| - | === Other FDX ===
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| - | | + | |
| - | [[3esx]], [[3esy]], [[3esz]], [[2v5u]], [[2v5v]], [[1obo]], [[1obv]] - AnFDX (mutant)<br />
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| - | [[1rcf]], [[1flv]] - AnFDX<br />
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| - | [[2wc1]] – FDX – ''Rhodobacter capsulatus''<br />
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| - | [[2w5u]] – HpFDX+C3 inhibitor 1fue - HpFDX<br />
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| - | [[2kaq]] – DdFDX <br />
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| - | [[2r97]], [[2r96]] – EcFDX WrbA<br />
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| - | [[1ahn]] – EcFDX<br />
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| - | [[2q9u]] – FDX di-iron – ''Giardia intestinalis''<br />
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| - | [[2ark]] – FDX – ''Aquifex aeolicus''<br />
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| - | [[1yob]] – FDX II – ''Azotobacter vinelandii''<br />
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| - | [[1j9e]], [[1f4p]], [[1i10]], [[1azl]] – DvFDX (mutant)<br />
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| - | [[1j8q]] - DvFDX<br />
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| | [[Category:Topic Page]] | | [[Category:Topic Page]] |
