Flavodoxin

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[[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N<sub>2</sub> to NH<sub>3</sub> while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red<ref>PMID:9416602</ref>. '''NrdI''' is a FDX which is involved in ribonucleotide reduction. '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX. In ''E. coli'' there are 2 distinct flavodoxins: FDX I and II.
[[Flavodoxin]] (FDX) is a bacterial protein which contains flavin mononucleotide (FMN) or flavin adenine dinucleotide (FAD). It participates in nitrogen metabolism and reduces N<sub>2</sub> to NH<sub>3</sub> while changing from its oxidized quinone state FDX-ox via semiquinone FDX-sq to its reduced hydroquinone state FDX-red<ref>PMID:9416602</ref>. '''NrdI''' is a FDX which is involved in ribonucleotide reduction. '''WrbA (Tryptophan Repressor-Binding Protein)''' is also FDX. In ''E. coli'' there are 2 distinct flavodoxins: FDX I and II.
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*<scene name='41/413119/Cv/3'>Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion</scene>.
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*<scene name='41/413119/Cv/5'>Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion</scene>.
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*<scene name='41/413119/Cv/4'>Cl coordination site</scene>. Water molecules shown as red spheres.
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*<scene name='41/413119/Cv/6'>Cl coordination site</scene>. Water molecules shown as red spheres.
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</StructureSection>
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== 3D Structures of Flavodoxin ==
== 3D Structures of Flavodoxin ==
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[[Flavodoxin 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Apo FDX
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**[[2kqu]], [[1dx9]] – AnFDX (mutant) apo – ''Anabanea'' – NMR<br />
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**[[2bmv]] – HpFDX apo - ''Helicobacter pylori''<br />
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**[[3d7n]] – FDX apo – ''Agrobacterium tumefaciens''<br />
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**[[2rg1]] - EcFDX WrbA apo - ''Escherichia coli''<br />
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**[[2hna]], [[2hnb]], [[2m6r]], [[2m6s]] – EcFDX apo – NMR<br />
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**[[1qhe]], [[1ftg]] – nFDX apo – Nostoc<br />
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**[[1bu5]] – DvFDX apo+riboflavin - ''Desulfovibrio vulgaris''<br />
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**[[5ljl]] - SpFDX - ''Streptococcus pneumoniae''<br />
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* FDX containing FMN oxidized (quinone)
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**[[3f6r]], [[3f6s]], [[3kap]] – DdFDX-ox - ''Desulfovibrio desulfuricans''<br />
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**[[4heq]] - FDX-ox – ''Desulfovibrio gigas'' <br />
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**[[1ag9]] – EcFDX-ox<br />
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**[[1flv]] – nFDX-ox<br />
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**[[1xyy]], [[1j9g]], [[1c7f]], [[1akr]], [[1akt]], [[1akw]] – DvFDX-ox (mutant)<br />
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**[[2fx2]], [[3fx2]], [[4fx2]], [[5fx2]], [[1fx1]] – DvFDX-ox<br />
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**[[1czk]], [[1czr]] – SeFDX-ox (mutant) - ''Synechococcus elongates''<br />
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**[[1czn]] – SeFDX-ox I<br />
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**[[1ofv]] – SeFDX-ox II<br />
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**[[1czu]], [[1d03]] - SeFDX-ox II<br />
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**[[2fdx]], [[1fld]], [[1fvx]], [[2fax]], [[3nll]], [[4nll]], [[4nul]], [[5nll]] – CbFDX-ox (mutant) - ''Clostridium beijerinckii''<br />
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**[[2fcr]] – FDX-ox – ''Chondrus crispus''<br />
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**[[1fue]] – HpFDX-ox<br />
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**[[4j8p]] - FDX-ox – ''Bacterioides uniformis'' <br />
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**[[1i1o]] - DvFDX-ox <br />
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**[[5lji]] - SpFDX-ox <br />
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* FDX containing FMNH (semiquinone)
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**[[2x2o]], [[2x2p]] – NrdI-sq – ''Bacillus cereus''<br />
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**[[3kaq]], [[3f90]] – DdFDX-sq <br />
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**[[1xt6]], [[1wsw]], [[1xyv]], [[1akv]], [[1wsb]] - DvFDX-sq (mutant)<br />
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**[[1czh]], [[1czl]] - SeFDX-sq (mutant)<br />
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**[[2fox]], [[5nul]]– CbFDX-sq<br />
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* FDX containing FMNH2 (hydroquinone)
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**[[2fz5]] – FDX-red – ''Megasphaera elsdenii'' – NMR<br />
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**[[1c7e]], [[1aku]], [[1akq]] - DvFDX-red (mutant)<br />
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**[[1czo]] - SeFDX-red (mutant)<br />
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**[[1d04]] – SeFDX-red<br />
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**[[1fla]], [[1fln]], [[2flv]], [[2fvx]], [[5ull]], [[6nul]] – CbFDX-red (mutant)<br />
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* Other FDX
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**[[3esx]], [[3esy]], [[3esz]], [[2v5u]], [[2v5v]], [[1obo]], [[1obv]] - AnFDX (mutant)<br />
 
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**[[1rcf]], [[1flv]] - AnFDX<br />
 
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**[[2wc1]] – FDX – ''Rhodobacter capsulatus''<br />
 
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**[[2w5u]] – HpFDX+C3 inhibitor 1fue - HpFDX<br />
 
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**[[2kaq]] – DdFDX <br />
 
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**[[2r97]], [[2r96]] – EcFDX WrbA<br />
 
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**[[1ahn]] – EcFDX<br />
 
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**[[2q9u]] – FDX di-iron – ''Giardia intestinalis''<br />
 
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**[[2ark]] – FDX – ''Aquifex aeolicus''<br />
 
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**[[1yob]] – FDX II – ''Azotobacter vinelandii''<br />
 
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**[[1j9e]], [[1f4p]], [[1i10]], [[1azl]] – DvFDX (mutant)<br />
 
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**[[1j8q]] - DvFDX<br />
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Apo-Flavodoxin from Helicobacter pylori complexed with benzamidine and chloride ion (PDB code 2bmv)

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References

  1. ↑ Hoover DM, Ludwig ML. A flavodoxin that is required for enzyme activation: the structure of oxidized flavodoxin from Escherichia coli at 1.8 A resolution. Protein Sci. 1997 Dec;6(12):2525-37. PMID:9416602 doi:10.1002/pro.5560061205

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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