Formate dehydrogenase

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<StructureSection load='' size='350' side='right' scene='49/491980/Cv/1' caption='NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, [[2nad]]'>
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'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe4S4 center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys]], [[Mo]], [[molybdopterin guanosine dinucleotide (MGD) cofactor and Fe4S4.
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==3D structure of formate dehydrogenase==
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'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome. The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.
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*<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
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*<scene name='49/491980/Cv/9'>Azide ion binding site</scene>.
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'''NAD-dependent FDH'''
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==3D structure of formate dehydrogenase==
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[[Formate dehydrogenase 3D structures]]
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[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
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</StructureSection>
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[[2fss]] – CbFDH – ''Candida boidinii''<BR />
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[[2j6i]] – CbFDH C terminal (mutant) <BR />
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[[3fn4]] - MoFDH – Moraxella<BR />
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[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
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[[2nad]] – PsFDH + NAD<BR />
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[[2gug]] – PsFDH + formate<BR />
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[[2gsd]] – MoFDH + NAD + N3<BR />
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[[3n7u]] - ArFDH + NAD + N3<BR />
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'''Mo-dependent FDH'''
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== References ==
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<references/>
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[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR />
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[[Category:Topic Page]]
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[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
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[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
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[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
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[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
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Current revision

NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, 2nad

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References

  1. ↑ Ferry JG. Formate dehydrogenase. FEMS Microbiol Rev. 1990 Dec;7(3-4):377-82. PMID:2094290

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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