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| - | {{STRUCTURE_2nad| PDB=2nad | SIZE=400| SCENE= |right|CAPTION=NAD-dependent formate dehydrogenase complex with cofactor NAD and sulfate, [[2nad]]}}
| + | <StructureSection load='' size='350' side='right' scene='49/491980/Cv/1' caption='NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, [[2nad]]'> |
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| - | '''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe4S4 center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe4S4.
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| - | ==3D structure of formate dehydrogenase==
| + | '''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome. The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>. |
| | + | *<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres. |
| | + | *<scene name='49/491980/Cv/9'>Azide ion binding site</scene>. |
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| - | '''NAD-dependent FDH'''
| + | ==3D structure of formate dehydrogenase== |
| | + | [[Formate dehydrogenase 3D structures]] |
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| - | [[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
| + | </StructureSection> |
| - | [[2fss]] – CbFDH – ''Candida boidinii''<BR />
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| - | [[2j6i]] – CbFDH C terminal (mutant) <BR />
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| - | [[3fn4]] - MoFDH – ''Moraxella''<BR />
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| - | [[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
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| - | [[2nad]] – PsFDH + NAD<BR />
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| - | [[2gug]] – PsFDH + formate<BR />
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| - | [[2gsd]] – MoFDH + NAD + N3<BR />
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| - | [[3n7u]] - ArFDH + NAD + N3<BR />
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| - | '''Mo-dependent FDH'''
| + | == References == |
| | + | <references/> |
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| - | [[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR /> | + | [[Category:Topic Page]] |
| - | [[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
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| - | [[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
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| - | [[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
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| - | [[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
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