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Formate dehydrogenase

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'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome. The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.
'''Formate dehydrogenase''' (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either [[NAD]]+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe<sub>4</sub>S<sub>4</sub> center and then to cytochrome. The '''Mo-dependent FDH-H''' from ''E. coli'' contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe<sub>4</sub>S<sub>4</sub><ref>PMID:2094290</ref>.
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*<scene name='49/491980/Cv/6'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
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*<scene name='49/491980/Cv/8'>NAD binding site</scene> in NAD-dependent formate dehydrogenase ([[2nad]]). Water molecules shown as red spheres.
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*<scene name='49/491980/Cv/7'>Azide ion binding site</scene>.
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*<scene name='49/491980/Cv/9'>Azide ion binding site</scene>.
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</StructureSection>
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==3D structure of formate dehydrogenase==
==3D structure of formate dehydrogenase==
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[[Formate dehydrogenase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*NAD-dependent FDH
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**[[2nac]], [[2go1]] – PsFDH – ''Pseudomonas''<BR />
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**[[2fss]], [[5dna]] – CbFDH – ''Candida boidinii''<BR />
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**[[2j6i]] – CbFDH C terminal (mutant) <BR />
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**[[3fn4]] - MoFDH – ''Moraxella''<BR />
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**[[3naq]], [[3jtm]] – ArFDH – ''Arabidopsis thaliana''<BR />
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**[[2nad]] – PsFDH + NAD<BR />
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**[[2gug]] – PsFDH + formate<BR />
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**[[2gsd]] – MoFDH + NAD + N3<BR />
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**[[3n7u]] - ArFDH + NAD + N3<BR />
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**[[3wr5]] – FDH + NAD – ''Thiobacillus''<br />
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**[[4xyg]] – GmFDH – ''Granulicella mallensis''<br />
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**[[4xyb]] – GmFDH + NADP <br />
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**[[4xye]] – GmFDH + NAD<br />
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*Mo-dependent FDH
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**[[1aa6]], [[1fdo]], [[2iv2]] – EcFDH-H + Fe4S4 + MGD – ''Escherichia coli''<BR />
 
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**[[1fdi]] - EcFDH-H + Fe4S4 + NO2 + MGD<BR />
 
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**[[1kqf]] - EcFDH-N + Fe4S4 + protoporphyrin + MGD<BR />
 
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**[[1kqg]] - EcFDH-N + Fe4S4 + protoporphyrin + heptyl-oxy-quinolinol + MGD<BR />
 
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**[[1h0h]] - FDH + Fe4S4 +MGD – ''Desulfovibrio gigas''
 
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, 2nad

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References

  1. ↑ Ferry JG. Formate dehydrogenase. FEMS Microbiol Rev. 1990 Dec;7(3-4):377-82. PMID:2094290

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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