GABA(A) receptor-associated protein
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='400' side='right' caption='Human GABARAP (deep sky blue) complex with LIR peptide (green) (PDB entry [[4xc2]])' scene='77/775216/Cv/1'> |
== Function == | == Function == | ||
| - | '''GABA(A) receptor-associated protein''' (GABARAP) is associated and promotes the clustering of GABA(A) receptors in fibroids<ref>PMID:10984509</ref>. GABARAP interacts with the | + | '''GABA(A) receptor-associated protein''' (GABARAP) is associated and promotes the clustering of GABA(A) receptors in fibroids<ref>PMID:10984509</ref>. GABARAP interacts with the γ2 subunit of GABA(A) receptor<ref>PMID:9892355</ref>. GABARAP transports GABA(A) receptors to the plasma membrane of neurons<ref>PMID:15601949</ref>. '''GABARAP-like 1''' (GABARAPL1) is ubiquitin-like and it increases cell-surface expression of κ-type opioid receptor and is involved in the elongation of the phagophore membrane. |
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== Relevance == | == Relevance == | ||
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| + | GABARAP is an autoantigen in stiff-person syndrome<ref>PMID:16984900</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| + | The <scene name='77/775216/Cv/2'>peptide which interacts with GABARAP is located between 2 hydrophobic pockets</scene><ref>PMID:25684205</ref>. <scene name='77/775216/Cv/3'>Interactions between GABARAP and LIR peptide</scene>. | ||
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| + | == 3D Structures of GABA receptor-associated protein == | ||
| + | [[GABA receptor-associated protein 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of deaminase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *GABARAP | ||
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| - | **[[1gnu]], [[1kjt]] – hGABARAP – human<br /> | ||
| - | **[[1kot]], [[1klv]], [[1km7]] – hGABARAP – NMR<br /> | ||
| - | **[[3d32]] – hGABARAP + peptide<br /> | ||
| - | **[[3dow]] – hGABARAP + calreticulin peptide<br /> | ||
| - | **[[3wim]], [[4xc2]], [[5lxh]] – hGABARAP + LIR peptide<br /> | ||
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| - | *GABARAPL1 | ||
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| - | **[[2r2q]] – hGABARAPL1<br /> | ||
| - | **[[2l8j]], [[5dpt]], [[5lxi]] – hGABARAPL1 + LIR peptide<br /> | ||
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| - | *GABARAPL2 | ||
| - | **[[4co7]] – hGABARAPL2<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
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References
- ↑ Chen L, Wang H, Vicini S, Olsen RW. The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11557-62. doi:, 10.1073/pnas.190133497. PMID:10984509 doi:http://dx.doi.org/10.1073/pnas.190133497
- ↑ Wang H, Bedford FK, Brandon NJ, Moss SJ, Olsen RW. GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton. Nature. 1999 Jan 7;397(6714):69-72. PMID:9892355 doi:http://dx.doi.org/10.1038/16264
- ↑ Leil TA, Chen ZW, Chang CS, Olsen RW. GABAA receptor-associated protein traffics GABAA receptors to the plasma membrane in neurons. J Neurosci. 2004 Dec 15;24(50):11429-38. doi: 10.1523/JNEUROSCI.3355-04.2004. PMID:15601949 doi:http://dx.doi.org/10.1523/JNEUROSCI.3355-04.2004
- ↑ Raju R, Rakocevic G, Chen Z, Hoehn G, Semino-Mora C, Shi W, Olsen R, Dalakas MC. Autoimmunity to GABAA-receptor-associated protein in stiff-person syndrome. Brain. 2006 Dec;129(Pt 12):3270-6. doi: 10.1093/brain/awl245. Epub 2006 Sep 19. PMID:16984900 doi:http://dx.doi.org/10.1093/brain/awl245
- ↑ Genau HM, Huber J, Baschieri F, Akutsu M, Dotsch V, Farhan H, Rogov V, Behrends C. CUL3-KBTBD6/KBTBD7 Ubiquitin Ligase Cooperates with GABARAP Proteins to Spatially Restrict TIAM1-RAC1 Signaling. Mol Cell. 2015 Feb 11. pii: S1097-2765(14)01018-1. doi:, 10.1016/j.molcel.2014.12.040. PMID:25684205 doi:http://dx.doi.org/10.1016/j.molcel.2014.12.040
