Latrophilin

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== Structural highlights ==
== Structural highlights ==
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The high-affinity of the LAT-3/FLRT3 complex is achieved by a combination of interactions between the <scene name='74/748875/Cv/2'>round face of LAT-3 and the concave surface of FLRT3</scene><ref>PMID:26235030</ref>. <scene name='74/748875/Cv/3'>All interactions</scene>.
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The high-affinity of the LAT-3/FLRT3 complex is achieved by a combination of interactions between the <scene name='74/748875/Cv/4'>round face of LAT-3 and the concave surface of FLRT3</scene><ref>PMID:26235030</ref>. <scene name='74/748875/Cv/5'>All interactions</scene>.
</StructureSection>
</StructureSection>

Revision as of 10:46, 4 July 2019

Human latrophilin-3 olfactomedin domain (magenta) complex with leucine-rich repeat transmembrane protein 3 (blue) and Ca+2 ion (green) (PDB code 5cmn)

Drag the structure with the mouse to rotate

3D structures of lactophilin

Updated on 04-July-2019

References

  1. ↑ Silva JP, Ushkaryov YA. The latrophilins, "split-personality" receptors. Adv Exp Med Biol. 2010;706:59-75. PMID:21618826
  2. ↑ Arcos-Burgos M, Jain M, Acosta MT, Shively S, Stanescu H, Wallis D, Domene S, Velez JI, Karkera JD, Balog J, Berg K, Kleta R, Gahl WA, Roessler E, Long R, Lie J, Pineda D, Londono AC, Palacio JD, Arbelaez A, Lopera F, Elia J, Hakonarson H, Johansson S, Knappskog PM, Haavik J, Ribases M, Cormand B, Bayes M, Casas M, Ramos-Quiroga JA, Hervas A, Maher BS, Faraone SV, Seitz C, Freitag CM, Palmason H, Meyer J, Romanos M, Walitza S, Hemminger U, Warnke A, Romanos J, Renner T, Jacob C, Lesch KP, Swanson J, Vortmeyer A, Bailey-Wilson JE, Castellanos FX, Muenke M. A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. Mol Psychiatry. 2010 Nov;15(11):1053-66. doi: 10.1038/mp.2010.6. Epub 2010 Feb, 16. PMID:20157310 doi:http://dx.doi.org/10.1038/mp.2010.6
  3. ↑ Lu YC, Nazarko OV, Sando R 3rd, Salzman GS, Sudhof TC, Arac D. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure. 2015 Jul 28. pii: S0969-2126(15)00277-4. doi:, 10.1016/j.str.2015.06.024. PMID:26235030 doi:http://dx.doi.org/10.1016/j.str.2015.06.024

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