Lysine-specific histone demethylase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 12: Line 12:
== Structural highlights ==
== Structural highlights ==
-
<scene name='48/485631/Cv/2'>Human FAD-containing LSD1 with CoREST and histone H3 helix</scene>. <scene name='48/485631/Cv/3'>LSD1 contains several domains</scene>: a flexible N-terminal domain, a SWIRM domain (an α-helical domain found in chromosomal proteins mediating protein-protein interactions in chromatin), a substrate and FAD-binding domain, a tower domain (a pair of 2 long anti-parallel helices supporting a 3-helix bundle) and a C-terminal domain<ref>PMID:16956976</ref>. <scene name='48/485631/Cv/4'>FAD binding site</scene>.
+
<scene name='48/485631/Cv/5'>Human FAD-containing LSD1 with CoREST and histone H3 helix</scene>. <scene name='48/485631/Cv/6'>LSD1 contains several domains</scene>: a flexible N-terminal domain, a SWIRM domain (an α-helical domain found in chromosomal proteins mediating protein-protein interactions in chromatin), a substrate and FAD-binding domain, a tower domain (a pair of 2 long anti-parallel helices supporting a 3-helix bundle) and a C-terminal domain<ref>PMID:16956976</ref>. <scene name='48/485631/Cv/7'>FAD binding site</scene>.
</StructureSection>
</StructureSection>
==3D structures of lysine-specific histone demethylase==
==3D structures of lysine-specific histone demethylase==

Revision as of 10:42, 8 July 2019

Human FAD-containing LSD1 (cyan) complex with CoREST (green) and histone H3 helix (deeppink), 2v1d

Drag the structure with the mouse to rotate

3D structures of lysine-specific histone demethylase

Updated on 08-July-2019

References

  1. ↑ Chen Y, Jie W, Yan W, Zhou K, Xiao Y. Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy. Crit Rev Eukaryot Gene Expr. 2012;22(1):53-9. PMID:22339659
  2. ↑ Kong SY, Kim W, Lee HR, Kim HJ. The histone demethylase KDM5A is required for the repression of astrocytogenesis and regulated by the translational machinery in neural progenitor cells. FASEB J. 2018 Feb;32(2):1108-1119. doi: 10.1096/fj.201700780R. Epub 2018 Jan 3. PMID:29212818 doi:http://dx.doi.org/10.1096/fj.201700780R
  3. ↑ Pollock JA, Larrea MD, Jasper JS, McDonnell DP, McCafferty DG. Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERalpha-dependent and -independent manners. ACS Chem Biol. 2012 Jul 20;7(7):1221-31. doi: 10.1021/cb300108c. Epub 2012 May, 10. PMID:22533360 doi:http://dx.doi.org/10.1021/cb300108c
  4. ↑ van Essen D, Zhu Y, Saccani S. A feed-forward circuit controlling inducible NF-kappaB target gene activation by promoter histone demethylation. Mol Cell. 2010 Sep 10;39(5):750-60. doi: 10.1016/j.molcel.2010.08.010. PMID:20832726 doi:http://dx.doi.org/10.1016/j.molcel.2010.08.010
  5. ↑ Li X, Liu L, Yang S, Song N, Zhou X, Gao J, Yu N, Shan L, Wang Q, Liang J, Xuan C, Wang Y, Shang Y, Shi L. Histone demethylase KDM5B is a key regulator of genome stability. Proc Natl Acad Sci U S A. 2014 May 13;111(19):7096-101. doi:, 10.1073/pnas.1324036111. Epub 2014 Apr 28. PMID:24778210 doi:http://dx.doi.org/10.1073/pnas.1324036111
  6. ↑ Chen Y, Yang Y, Wang F, Wan K, Yamane K, Zhang Y, Lei M. Crystal structure of human histone lysine-specific demethylase 1 (LSD1). Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13956-61. Epub 2006 Sep 6. PMID:16956976

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Lysine-specific_histone_demethylase"
Personal tools