Geranylgeranyl pyrophosphate synthase

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<StructureSection load='' size='350' side='right' scene='54/540181/Cv/1' caption='Geranylgeranyl pyrophosphate synthase dimer complex with GGPP and Mg+2 (green) [[2z4v]]'>
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{{STRUCTURE_2z4v| PDB=2z4v | SIZE=350| SCENE= |right|CAPTION=Geranylgeranyl pyrophosphate synthase dimer complex with GGPP and Mg+2 (green) [[2z4v]] }}
 
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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GGPP - the product of GGPPS catalysis interacts with Mg+2 ions in the active site<ref>PMID:18800762</ref>.
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<scene name='54/540181/Cv/5'>GGPP - the product of GGPPS catalysis interacts with Mg+2 ions in the active site</scene><ref>PMID:18800762</ref>. Water molecules shown as red spheres.
== 3D Structures of geranylgeranyl pyrophosphate synthase==
== 3D Structures of geranylgeranyl pyrophosphate synthase==
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[[Geranylgeranyl pyrophosphate synthase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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[[2dh4]] – yGGPPS + Mg - yeast<br />
 
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[[2e8t]] – yGGPPS + Mg + isopentenyl pyrophosphate + farnesyl thiopyrophosphate<br />
 
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[[2e8u]], [[2e8w]] – yGGPPS + Mg + isopentenyl pyrophosphate <br />
 
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[[2e8v]] – yGGPPS + GGPP<br />
 
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[[2z4v]] – yGGPPS + GGPP + Mg<br />
 
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[[2e8x]] – yGGPPS + GPP + Mg<br />
 
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[[2e90]] – yGGPPS + Mg + PP + farnesyl pyrophosphate<br />
 
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[[2e91]], [[2e92]], [[2e93]], [[2e94]], [[2e95]], [[2z7h]], [[2z4w]], [[2z4x]], [[2z4y]], [[2z4z]], [[2z50]], [[2z52]], [[2z78]], [[2z7i]], [[2zeu]] – yGGPPS + Mg + inhibitor<br />
 
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[[2zev]] – yGGPPS + Mg + isopentenyl pyrophosphate + inhibitor<br />
 
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[[2q80]] – GGPPS + GGPP + Mg - human<br />
 
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[[2azj]] – SsGGPPS – ''Sulfolobus solfataricus''<br />
 
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[[2azk]] – SsGGPPS (mutant)<br />
 
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[[3lk5]], [[3lmd]] – CgGGPPS – ''Corynebacterium glutamicum''<br />
 
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[[3q2q]] – CgGGPPS + Ca + isoprenyl diphosphate <br />
 
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[[3qqv]] – CgGGPPS + Mg + isoprenyl diphosphate <br />
 
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[[3n3d]], [[3pko]] – GGPPS – ''Lactobacillus brevis''<br />
 
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[[2j1o]] – SaGGPPS – ''Sinapis alba''<br />
 
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[[2j1p]] – SaGGPPS + GGPP<br />
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Geranylgeranyl pyrophosphate synthase dimer complex with GGPP and Mg+2 (green) 2z4v

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References

  1. ↑ Croteau R, Purkett PT. Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis). Arch Biochem Biophys. 1989 Jun;271(2):524-35. PMID:2730002
  2. ↑ Wiemer AJ, Wiemer DF, Hohl RJ. Geranylgeranyl diphosphate synthase: an emerging therapeutic target. Clin Pharmacol Ther. 2011 Dec;90(6):804-12. doi: 10.1038/clpt.2011.215. Epub 2011, Nov 2. PMID:22048229 doi:http://dx.doi.org/10.1038/clpt.2011.215
  3. ↑ K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. PMID:18800762 doi:10.1021/jm800325y

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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