Geranylgeranyl pyrophosphate synthase
From Proteopedia
(Difference between revisions)
| Line 17: | Line 17: | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of geranylgeranyl pyrophosphate synthase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | |||
| - | [[2dh4]] – yGGPPS + Mg - yeast<br /> | ||
| - | [[2e8t]] – yGGPPS + Mg + isopentenyl pyrophosphate + farnesyl thiopyrophosphate<br /> | ||
| - | [[2e8u]], [[2e8w]] – yGGPPS + Mg + isopentenyl pyrophosphate <br /> | ||
| - | [[2e8v]] – yGGPPS + GGPP<br /> | ||
| - | [[2z4v]] – yGGPPS + GGPP + Mg<br /> | ||
| - | [[2e8x]] – yGGPPS + GPP + Mg<br /> | ||
| - | [[2e90]] – yGGPPS + Mg + PP + farnesyl pyrophosphate<br /> | ||
| - | [[2e91]], [[2e92]], [[2e93]], [[2e94]], [[2e95]], [[2z7h]], [[2z4w]], [[2z4x]], [[2z4y]], [[2z4z]], [[2z50]], [[2z52]], [[2z78]], [[2z7i]], [[2zeu]] – yGGPPS + Mg + inhibitor<br /> | ||
| - | [[2zev]] – yGGPPS + Mg + isopentenyl pyrophosphate + inhibitor<br /> | ||
| - | [[2q80]] – GGPPS + GGPP + Mg - human<br /> | ||
| - | [[2azj]] – SsGGPPS – ''Sulfolobus solfataricus''<br /> | ||
| - | [[2azk]] – SsGGPPS (mutant)<br /> | ||
| - | [[3lk5]], [[3lmd]] – CgGGPPS – ''Corynebacterium glutamicum''<br /> | ||
| - | [[3q2q]] – CgGGPPS + Ca + isoprenyl diphosphate <br /> | ||
| - | [[3qqv]] – CgGGPPS + Mg + isoprenyl diphosphate <br /> | ||
| - | [[3n3d]], [[3pko]] – GGPPS – ''Lactobacillus brevis''<br /> | ||
| - | [[2j1o]] – SaGGPPS – ''Sinapis alba''<br /> | ||
| - | [[2j1p]] – SaGGPPS + GGPP<br /> | ||
| - | [[5e8h]] – AtGGPPS-3 – ''Arabidopsis thaliana''<br /> | ||
| - | [[5e8k]] – AtGGPPS-10<br /> | ||
| - | [[5e8l]] – AtGGPPS-11<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ Croteau R, Purkett PT. Geranyl pyrophosphate synthase: characterization of the enzyme and evidence that this chain-length specific prenyltransferase is associated with monoterpene biosynthesis in sage (Salvia officinalis). Arch Biochem Biophys. 1989 Jun;271(2):524-35. PMID:2730002
- ↑ Wiemer AJ, Wiemer DF, Hohl RJ. Geranylgeranyl diphosphate synthase: an emerging therapeutic target. Clin Pharmacol Ther. 2011 Dec;90(6):804-12. doi: 10.1038/clpt.2011.215. Epub 2011, Nov 2. PMID:22048229 doi:http://dx.doi.org/10.1038/clpt.2011.215
- ↑ K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. J Med Chem. 2008 Sep 25;51(18):5594-607. PMID:18800762 doi:10.1021/jm800325y
