Manganese peroxidase
From Proteopedia
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| - | < | + | <StructureSection load='3m5q' size='450' side='right' scene='48/486477/Cv/1' caption='Heme-containing glycosylated manganese peroxidase complex with glycerol, Mn+2 (purple) and Ca+2 (green) ions [[3m5q]]'> |
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| - | ''' | + | |
| + | == Function == | ||
| + | '''Manganese peroxidase''' (MnP) catalyzes the conversion of Mn+2 to Mn+3 using hydrogen peroxide. MnP contains a heme group and needs calcium ion for activity. MnP is involved in lignin degradation. MnP is produced by wood-rotting fungi<ref>PMID:10712608</ref>. ''Ceriporiopsis subvermispora'' expresses 3 genes of MnP: a short, long and '''extralong'''. | ||
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| + | == Relevance == | ||
| + | Mn+3 in a chelated form is a powerful oxidizing agent which is able to mineralize lignin to CO2. | ||
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| + | == Structural highlights == | ||
| + | The <scene name='48/486477/Cv/7'>Mn binding site of MnP contains the heme group which coordinates with the ion</scene>. Water molecules are shown as red spheres. The <scene name='48/486477/Cv/8'>heme group is coordinated mostly by aromatic side chains</scene><ref>PMID:20356630</ref>. | ||
| + | </StructureSection> | ||
==3D structures of manganese peroxidase== | ==3D structures of manganese peroxidase== | ||
| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| + | *Manganese peroxidase 1 | ||
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| + | **[[1mnp]], [[1yyd]], [[1yyg]], [[1yzp]], [[3m8m]] – PcMnP – ''Phanerochaete chrysosporium''<br /> | ||
| + | **[[1mn1]], [[1mn2]] – PcMnP (mutant)<br /> | ||
| + | **[[1yzr]] – PcMnP + Sm<br /> | ||
| + | **[[3m5q]] – PcMnP + Mn<br /> | ||
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| + | *Manganese peroxidase 4 | ||
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| + | **[[4bm1]], [[4bm2]], [[4bm3]], [[4bm4]] – MnP 4 – ''Pleurotus ostreatus''<br /> | ||
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| + | *Extralong manganese peroxidase | ||
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| + | **[[4czn]] – CsMnP – ''Ceriporiopsis subvermispora''<br /> | ||
| + | **[[4czo]], [[4czp]] – CsMnP + Mn<br /> | ||
| + | **[[4czq]], [[4czr]] – CsMnP + Cd<br /> | ||
| + | }} | ||
| + | == References == | ||
| + | <references/> | ||
| - | [[ | + | [[Category:Topic Page]] |
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Current revision
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3D structures of manganese peroxidase
Updated on 09-July-2019
References
- ↑ Youngs HL, Sundaramoorthy M, Gold MH. Effects of cadmium on manganese peroxidase competitive inhibition of MnII oxidation and thermal stabilization of the enzyme. Eur J Biochem. 2000 Mar;267(6):1761-9. PMID:10712608
- ↑ Sundaramoorthy M, Gold MH, Poulos TL. Ultrahigh (0.93A) resolution structure of manganese peroxidase from Phanerochaete chrysosporium: implications for the catalytic mechanism. J Inorg Biochem. 2010 Jun;104(6):683-90. Epub 2010 Mar 6. PMID:20356630 doi:10.1016/j.jinorgbio.2010.02.011
