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6gse

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Revision as of 06:21, 10 July 2019

Solution structure of the capsid domain from the activity-regulated cytoskeleton-associated protein, Arc

Structural highlights

6gse is a 1 chain structure with sequence from Buffalo rat. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	Arc (Buffalo rat)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[ARC_RAT] Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.^[1] ^[2]

Publication Abstract from PubMed

The activity-regulated cytoskeleton-associated protein, Arc, is highly expressed in neuronal dendrites and is involved in synaptic scaling and plasticity. Arc exhibits homology to the capsid-forming Gag proteins from retroviruses and can encapsulate its own mRNA and transport it to neighboring neurons. However, the molecular events that lead to the assembly of Arc capsids and how the capsid formation is regulated are not known. Here we show that the capsid domain of Arc may transiently form homogeneous oligomers of similar size as capsids formed by full-length Arc. We determined a high-resolution structure of the monomeric Arc capsid domain and mapped the initial structural change in the oligomerization process to the N-terminal part of the capsid domain. Peptide ligands from the NMDA receptor subunits inhibit oligomerization, which suggests that Arc's ability to transfer mRNA between cells may be regulated by protein-protein interactions at the synapse.

The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor.,Nielsen LD, Pedersen CP, Erlendsson S, Teilum K Structure. 2019 Apr 16. pii: S0969-2126(19)30123-6. doi:, 10.1016/j.str.2019.04.001. PMID:31080121^[3]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Rial Verde EM, Lee-Osbourne J, Worley PF, Malinow R, Cline HT. Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron. 2006 Nov 9;52(3):461-74. PMID:17088212 doi:http://dx.doi.org/10.1016/j.neuron.2006.09.031
↑ Shepherd JD, Rumbaugh G, Wu J, Chowdhury S, Plath N, Kuhl D, Huganir RL, Worley PF. Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. Neuron. 2006 Nov 9;52(3):475-84. PMID:17088213 doi:http://dx.doi.org/S0896-6273(06)00683-0
↑ Nielsen LD, Pedersen CP, Erlendsson S, Teilum K. The Capsid Domain of Arc Changes Its Oligomerization Propensity through Direct Interaction with the NMDA Receptor. Structure. 2019 Apr 16. pii: S0969-2126(19)30123-6. doi:, 10.1016/j.str.2019.04.001. PMID:31080121 doi:http://dx.doi.org/10.1016/j.str.2019.04.001

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6gse"

@@ Line 3: / Line 3: @@
 <StructureSection load='6gse' size='340' side='right'caption='[[6gse]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6gse]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GSE FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6gse]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GSE FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gse OCA], [http://pdbe.org/6gse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gse RCSB], [http://www.ebi.ac.uk/pdbsum/6gse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gse ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Arc ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gse OCA], [http://pdbe.org/6gse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gse RCSB], [http://www.ebi.ac.uk/pdbsum/6gse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gse ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Buffalo rat]]
 [[Category: Large Structures]]
 [[Category: Erlendsson, S]]

6gse

From Proteopedia

Revision as of 06:21, 10 July 2019

Solution structure of the capsid domain from the activity-regulated cytoskeleton-associated protein, Arc

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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