Met repressor

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Current revision (10:30, 10 July 2019) (edit) (undo)
 
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== Structural highlights ==
== Structural highlights ==
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<scene name='53/536702/Cv/2'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/6'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>. Water molecules shown as red spheres.
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<scene name='53/536702/Cv/7'>EcMR (mutant) with corepressor SAM, Ca+2 ion and DNA</scene>. <scene name='53/536702/Cv/8'>SAM binds to MR in a hydrophobic pocket between 2 monomers</scene><ref>PMID:10986458</ref>. Water molecules are shown as red spheres.
</StructureSection>
</StructureSection>
== 3D Structures of Met repressor ==
== 3D Structures of Met repressor ==

Current revision

EcMR (mutant) complex with corepressor SAM, Ca+2 ion (green) and DNA 1mjo

Drag the structure with the mouse to rotate

3D Structures of Met repressor

Updated on 10-July-2019

1cmb – EcMR – Escherichia coli
1mjk – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA

References

  1. Somers WS, Rafferty JB, Phillips K, Strathdee S, He YY, McNally T, Manfield I, Navratil O, Old IG, Saint-Girons I, et al.. The Met repressor-operator complex: DNA recognition by beta-strands. Ann N Y Acad Sci. 1994 Jul 29;726:105-17. PMID:8092669
  2. Garvie CW, Phillips SE. Direct and indirect readout in mutant Met repressor-operator complexes. Structure. 2000 Sep 15;8(9):905-14. PMID:10986458

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Michal Harel, Alexander Berchansky

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