This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3kat

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{Seed}} 200px <!-- The line below this paragraph, containing "STRUCTURE_3kat", creates the "Structure Box" on the page. You may change the PDB parameter (which se...)
Current revision (11:07, 17 July 2019) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3kat.jpg|left|200px]]
 
-
<!--
+
==Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E==
-
The line below this paragraph, containing "STRUCTURE_3kat", creates the "Structure Box" on the page.
+
<StructureSection load='3kat' size='340' side='right'caption='[[3kat]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3kat]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KAT FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-
-->
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CARD7, DEFCAP, KIAA0926, NAC, NALP1, NLRP1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-
{{STRUCTURE_3kat| PDB=3kat | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kat FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kat OCA], [http://pdbe.org/3kat PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kat RCSB], [http://www.ebi.ac.uk/pdbsum/3kat PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kat ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E===
+
== Disease ==
-
 
+
[[http://www.uniprot.org/uniprot/NALP1_HUMAN NALP1_HUMAN]] Genetic variations in NLRP1 are associated with susceptibility to vitiligo (VTLG) [MIM:[http://omim.org/entry/193200 193200]]. VTLG is a pigmentary disorder of the skin characterized by circumscribed depigmented macules and patches, commonly on extensor aspects of extremities, on the face or neck and in skin folds. It is a progressive disorder in which some or all of the melanocytes in the affected skin are selectively destroyed. It is a multifactorial disorder with a complex etiology probably including autoimmune mechanisms, and is associated with an elevated risk of other autoimmune diseases.<ref>PMID:17377159</ref> Genetic variations in NLRP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1 (VAMAS1) [MIM:[http://omim.org/entry/606579 606579]]. VAMAS1 is an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.<ref>PMID:17377159</ref>
-
 
+
== Function ==
-
==About this Structure==
+
[[http://www.uniprot.org/uniprot/NALP1_HUMAN NALP1_HUMAN]] Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP.<ref>PMID:12191486</ref> <ref>PMID:15212762</ref> <ref>PMID:17349957</ref>
-
3KAT is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KAT OCA].
+
== Evolutionary Conservation ==
-
[[Category: Homo sapiens]]
+
[[Image:Consurf_key_small.gif|200px|right]]
-
[[Category: Abashidze, M.]]
+
Check<jmol>
-
[[Category: Acton, T B.]]
+
<jmolCheckbox>
-
[[Category: Ciccosanti,C.]]
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ka/3kat_consurf.spt"</scriptWhenChecked>
-
[[Category: Everett, J K.]]
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
[[Category: Forouhar,F.]]
+
<text>to colour the structure by Evolutionary Conservation</text>
-
[[Category: Hunt,J F.]]
+
</jmolCheckbox>
-
[[Category: Mao,M.]]
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kat ConSurf].
-
[[Category: Montelione, G T.]]
+
<div style="clear:both"></div>
-
[[Category: NESG, Northeast Structural Genomics Consortium.]]
+
== References ==
-
[[Category: Nair, R.]]
+
<references/>
-
[[Category: Rost, B.]]
+
__TOC__
-
[[Category: Seetharaman, J.]]
+
</StructureSection>
-
[[Category: Shastry,R.]]
+
[[Category: Human]]
-
[[Category: Tong,L.]]
+
[[Category: Large Structures]]
-
[[Category: Xiao,R.]]
+
[[Category: Abashidze, M]]
 +
[[Category: Acton, T B]]
 +
[[Category: Ciccosanti, C]]
 +
[[Category: Everett, J K]]
 +
[[Category: Forouhar, F]]
 +
[[Category: Hunt, J F]]
 +
[[Category: Mao, M]]
 +
[[Category: Montelione, G T]]
 +
[[Category: Structural genomic]]
 +
[[Category: Nair, R]]
 +
[[Category: Rost, B]]
 +
[[Category: Seetharaman, J]]
 +
[[Category: Shastry, R]]
 +
[[Category: Tong, L]]
 +
[[Category: Xiao, R]]
[[Category: Alternative splicing]]
[[Category: Alternative splicing]]
 +
[[Category: Apoptosis]]
[[Category: Atp-binding]]
[[Category: Atp-binding]]
[[Category: Cytoplasm]]
[[Category: Cytoplasm]]
[[Category: Leucine-rich repeat]]
[[Category: Leucine-rich repeat]]
[[Category: Nesg]]
[[Category: Nesg]]
-
[[Category: Northeast structural genomics consortium]]
 
[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Nucleus]]
[[Category: Nucleus]]
[[Category: Polymorphism]]
[[Category: Polymorphism]]
-
[[Category: Protein structure initiative]]
+
[[Category: PSI, Protein structure initiative]]
-
[[Category: Psi-2]]
+
-
[[Category: Structural genomic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 28 14:06:46 2009''
+

Current revision

Crystal Structure of the CARD domain of the human NLRP1 protein, Northeast Structural Genomics Consortium Target HR3486E

PDB ID 3kat

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3kat"
Personal tools