Growth differentiation factor

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*'''GDF-11''' or '''bone morphogenetic protein 11''' is a circulating factor that reverses age-related cardiac hypertrophy<ref>PMID:23663781</ref>.
*'''GDF-11''' or '''bone morphogenetic protein 11''' is a circulating factor that reverses age-related cardiac hypertrophy<ref>PMID:23663781</ref>.
*'''GDF-15''' or '''placental bone morphogenetic protein''' protects the hart from ischmia and reperfusion injury<ref>PMID:16484622</ref>.
*'''GDF-15''' or '''placental bone morphogenetic protein''' protects the hart from ischmia and reperfusion injury<ref>PMID:16484622</ref>.
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==3D structures of growth differentiation factor==
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[[Growth differentiation factor 3D STRUCTURES]]
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</StructureSection>
</StructureSection>
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**[[5uhm]], [[5e4g]] – hGDF <br />
**[[5uhm]], [[5e4g]] – hGDF <br />
**[[5jhw]] – hGDF + follistatin <br />
**[[5jhw]] – hGDF + follistatin <br />
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**[[6mac]] – hGDF + activing receptor + TGF-b receptor <br />
*GDF-15
*GDF-15

Revision as of 07:26, 18 July 2019

Structure of growth differentiation factor GDF-5 (green and aqua) complex with bone morphogenetic receptor (pink and olive) (PDB entry 3evs)

Drag the structure with the mouse to rotate

3D structures of growth differentiation factor

Updated on 18-July-2019

References

  1. Jin L, Li X. Growth differentiation factor 5 regulation in bone regeneration. Curr Pharm Des. 2013;19(19):3364-73. PMID:23432680
  2. Ferrell RE, Conte V, Lawrence EC, Roth SM, Hagberg JM, Hurley BF. Frequent sequence variation in the human myostatin (GDF8) gene as a marker for analysis of muscle-related phenotypes. Genomics. 1999 Dec 1;62(2):203-7. PMID:10610713 doi:http://dx.doi.org/10.1006/geno.1999.5984
  3. Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, Sinha M, Dall'Osso C, Khong D, Shadrach JL, Miller CM, Singer BS, Stewart A, Psychogios N, Gerszten RE, Hartigan AJ, Kim MJ, Serwold T, Wagers AJ, Lee RT. Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013 May 9;153(4):828-39. doi: 10.1016/j.cell.2013.04.015. PMID:23663781 doi:http://dx.doi.org/10.1016/j.cell.2013.04.015
  4. Ago T, Sadoshima J. GDF15, a cardioprotective TGF-beta superfamily protein. Circ Res. 2006 Feb 17;98(3):294-7. doi: 10.1161/01.RES.0000207919.83894.9d. PMID:16484622 doi:http://dx.doi.org/10.1161/01.RES.0000207919.83894.9d

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Michal Harel, Alexander Berchansky

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