GTP-binding protein

From Proteopedia

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 </StructureSection>
 __NOTOC__
-== 3D Structures of GTP-binding protein ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*'''Small GTP-binding protein'''
-**[[2eki]] – hGBP TGS domain – NMR - human<br />
-**[[3r7w]], [[4arz]] – yGtr1 + Gtr2 – yeast<br />
-**[[3kxk]], [[3kxl]] – SsHflx (mutant) - ''Sulfolobus solfataricus''<br />
-**[[2qtf]] – SsHflx<br />
-**[[2dyk]] – TtEngA N terminal – ''Thermus thermophilus'' - Cryo EM<br />
-**[[5a9v]], [[4zci]] – EcBipA – ''Escherichia coli'' <br />
-**[[4zck]] – EcBipA  C-terminal<br />
-**[[1sul]] – BsYsxC - ''Bacillus subtilis''<br />
-**[[2dwq]] – TtYchF<br />
-**[[1udx]] – TtObg<br />
-**[[1wxq]] – GBP – ''Pyrococcus horikoshii''<br />
-**[[1yr6]] - PaGBP – ''Pyrococcus abyssi''<br />
-**[[1ni3]] – YchF – ''Schizosaccharomyces pombe''<br />
-**[[5oxf]], [[5owv]] – GBP – ''Campylobacter jejuni''<br />
-*GTP-binding protein complex with nucleotide
-**[[2nzj]] – hRem1 + GDP<br />
-**[[3cbq]] – hRem2 + GDP<br />
-**[[3q85]] – hRem2 G domain + GTP analog<br />
-**[[4aii]] - rRem2 G domain + GDP - rat<br />
-**[[2ohf]] – hOla1 + AMP-PCP<br />
-**[[1e0a]] – hGBP (mutant) + GIP<br />
-**[[2b8w]], [[2d4h]] – hGBP N terminal + GMP<br />
-**[[2b92]] - hGBP N terminal + GDP<br />
-**[[2bc9]] - hGBP N terminal + GPPNHP<br />
-**[[1yr7]], [[1yr8]] – PaGBP + GTP<br />
-**[[1yr9]], [[1yra]], [[1yrb]], [[2oxr]] – PaGBP + GDP<br />
-**[[3kxi]], [[2qth]] – SsHflx + GDP<br />
-**[[1yzn]] – yPt1 + GPPNHP<br />
-**[[1ky2]] – yPt7 + GPPNHP<br />
-**[[1ky3]] – yPt7 + GDP<br />
-**[[4phg]] – yPt7 (mutant) + GTP<br />
-**[[4phh]] – yPt7 (mutant) + GNP<br />
-**[[4phf]] – yPt7 (mutant) + GDP<br />
-**[[3rwm]], [[3rwo]] – yPt32 + GPPNHP<br />
-**[[1ek0]] – yPt51 + GPPNHP<br />
-**[[2hjg]], [[4dcs]], [[4dct]], [[4dcu]], [[4dcv]], [[4kyu]], [[5mbs]] – BsEngA + GDP<br />
-**[[5m7h]] – BsEngA + GMPPNP<br />
-**[[5x4b]] – BsEngA N-terminal + GDP<br />
-**[[1svi]] – BsYsxC + GDP<br />
-**[[1svw]] – BsYsxC + GMPPNP<br />
-**[[1lnz]] – BsObg + GTP<br />
-**[[5m04]] – BsObg + GDP<br />
-**[[2dby]] – TtYchF + GDP<br />
-**[[1wf3]] – Tt1341 + GNP<br />
-**[[2gao]] - hSar1A + GDP<br />
-**[[2fa9]] – ChSar1B (mutant) + GDP – Chinese hamster<br />
-**[[2fmx]] - ChSar1B + GDP<br />
-**[[5a9y]], [[4zcm]] – EcBipA + G-4-phosphate <br />
-**[[5a9x]], [[5a9w]], [[4zcl]] – EcBipA + GDP <br />
-**[[5dn8]] – EngA + GDP – ''Coxiella burnetti''<br />
-*GTP-binding protein complex with protein
-**[[3cue]] – yPt1 + transport protein subunits<br />
-**[[2bcg]], [[1ukv]] - yPt1 + secretory pathway GDP-dissociation inhibitor<br />
-**[[3cpj]] – yPt31 + Rab GDP-dissociation inhibitor<br />
-**[[1m2o]] – ySar1 + protein transport protein sec23<br />
-**[[6gni]] - ySar1 + protein transport protein sec23 + Sec24 + GNP<br />
-**[[3syn]] – BsFlhf + ATP-binding protein<br />
-*GTP-binding protein 3 (Atlastin-1)
-**[[4idn]] – hGDP3 cytoplasmic domain + GNP<br />
-**[[4ido]], [[4idq]], [[3q5d]], [[3q5e]], [[3qnu]], [[3qof]] – hGDP3 cytoplasmic domain + GDP<br />
-**[[6b9f]], [[6b9e]], [[6b9d]] – hGDP3 cytoplasmic domain (mutant) + GDP<br />
-* GTP-binding protein LepA
-**[[3cb4]] – EcLepA <br />
-**[[2ywe]] – AaLepA – ''Aquifex aeolicus''<br />
-**[[4k8w]] – LepA – ''Streptococcus pyogenes''<br />
-**[[2ywf]] – AaLepA + GMP-PNP<br />
-**[[2ywg]] - AaLepA + GTP<br />
-**[[2ywh]] - AaLepA + GDP<br />
-**[[3deg]] – EcLepA + A-tRNA + P-tRNA + RPS12 + RPL11 – Cryo EM<br />
-*G protein bound to a G protein-coupled receptor
-**[[3sn6]] - human β-2 adrenergic receptor + cameloid antibody fragment bound by guanine nucleotide-binding protein G. '''This is the first structure of an activated [[G protein-coupled receptor]] in a complex with its G protein.'''
-*'''Ras-related small GTP-binding protein'''
-**[[3llu]] – hRag-C nucleotide-binding domain<br />
-**[[2rhd]] – Rab-1a – ''Cryptosporidium parvum''<br />
-*Ras-related small GTP-binding protein complex with nucleotide
-**[[2l0x]] – rRheb + GDP <br />
-**[[2gjs]] – hRad1 + GDP<br />
-**[[3q72]], [[3q7p]], [[3q7q]] – hRad G-domain + GTP analog<br />
-**[[2dpx]] – hRad GTPase domain<br />
-**[[2gf0]] – hDiRas1 + GDP<br />
-**[[2erx]] – hDiRas2 + Pi + GDP<br />
-**[[3x1z]], [[3x1y]], [[3x1x]], [[3x1w]] – hRab-1B (mutant) + GPPNHP<br />
-**[[1yu9]] - hRab-4A + GPPNHP<br />
-**[[1yzq]] - hRab-6 + GNP<br />
-**[[1x3s]] – hRab-18 + GPPNHP
-**[[6huf]] - hRab-27A + GNP<br />
-**[[2atx]] – hTc10 + GPPNHP<br />
-**[[1g16]] – ySec4 + GDP<br />
-**[[1g17]] - ySec4 + GIP<br />
-*Ras-related small GTP-binding protein complex with protein
-**[[3kuc]] – hRap-1A + proto oncogene Ser/Thr protein kinase<br />
-**[[3cf6]] - hRap-1A + Rap guanine nucleotide exchange factor 4<br />
-**[[3brw]] - hRap-1B + Rap GTPase-activating protein<br />
-**[[4kvg]] – hRab-1A + RIAM<br />
-**[[6ba6]] – hRab-1B + talin-1<br />
-**[[4m8n]] – hRab-1B + plexin<br />
-**[[4dxa]] – hRab-1B (mutant) + KRIT1<br />
-**[[4hdq]], [[4hdo]] – hRab-1B + HEG1 + KRIT1<br />
-**[[6axf]] – hRab-1B + Ras guanyl-releasing protein 2<br />
-**[[5kho]] – hRab-1B + Ras-interacting protein 1<br />
-**[[4mh0]], [[4mgz]], [[4mgy]], [[4mgk]], [[4mgi]] - hRap-1B + Rap guanine nucleotide exchange factor 4<br />
-**[[1z0k]] – hRab-4 + rabenosyn-5<br />
-**[[3tw8]] – hRab-1C + DENND<br />
-**[[4ojk]] – hRab-11B + cGMP-dependent protein kinase 2<br />
-**[[6ekk]] – hRab-35 + connecdenn + GDP<br />
-**[[6if2]] – hRab-35 (mutant) + iporin + GTP<br />
-**[[6if3]] – hRab-35 (mutant) + ACAP2 + GTP<br />
-**[[6ces]] – hRag-C (mutant) + NPRL2 + NPRL3 + DEPDC5 + GNP – Cryo EM<br />
-**[[6ehr]], [[5x6v]] – hRag-A + hRag-C + lamtor1 + lamtor2 + lamtor3 + lamtor4 + lamtor5<br />
-*'''Interferon-induced GTP-binding protein'''
-**[[3ljb]] – hMx1 stalk region<br />
-**[[4p4u]] – hMx1 stalk region (mutant)<br />
-**[[4p4t]] – hMx1 stalk region (mutant) + GDP<br />
-**[[4p4s]] – hMx1 stalk region (mutant) + GMPPCP<br />
-**[[3szr]] – hMx1 residues 33-662<br />
-**[[5gtm]] – hMx1 residues 33-662 (mutant)<br />
-**[[3zys]] – hMx1 + dynamin-1<br />
-**[[4x0r]] – hMx2 stalk region (mutant)<br />
-**[[4whj]] – hMx2 residues 84-715 (mutant)<br />
-*'''Rho-related small GTP-binding protein'''
-**[[2j1l]] – hRhoD
-*Rho-related small GTP-binding protein complex with nucleotide
-**[[2cls]] – hRho6 + GTP<br />
-**[[2fv8]] - hRhoB + GDP<br />
-**[[2gcn]] – hRhoC + GDP<br />
-**[[2gco]] – hRhoC + GPPNHP<br />
-**[[1z2c]] - hRhoC (mutant) + GMPPNP<br />
-**[[2gcp]] – hRhoC + GSP<br />
-**[[1m7b]] - hRhoE + GTP<br />
-**[[1gwn]] - mRhoE + GTP <br />
-**[[1a4r]] - hCdc42 (mutant) + GDP<br />
-**[[1an0]] - hCdc42 + GDP<br />
-**[[2qrz]] - hCdc42 + GCP<br />
-*Rho-related small GTP-binding protein complex with protein
-**[[2v55]] – hRhoE + Rho-associated protein kinase<br />
-**[[3q3j]] – hRho6 + plexin-A2 nucleotide-binding domain<br />
-**[[2rex]] – hRho6 + plexin-B1<br />
-**[[1cc0]] – hRhoA + GDP-dissociation inhibitor + GDP<br />
-**[[6bca]] - hRhoA + kinase anchor protein + GTP<br />
-**[[3a58]] – yRho1 (mutant) + exocyst complex component Sec3 + cancidas<br />
-**[[1gzs]] – Cdc42 + guanine nucleotide exchange factor – ''Salmonella typhimurium''<br />
-**[[2kb0]] - hCdc42 (mutant)<br />
-**[[1kz7]] - hCdc42 + guanine nucleotide exchange factor<br />
-**[[1kzg]] - hCdc42 (mutant) + guanine nucleotide exchange factor (mutant)<br />
-**[[2dfk]] – hCdc42 + collybistin II<br />
-**[[2wm9]], [[2wmn]], [[2wmo]] - hCdc42 + DOCK9<br />
-**[[3eg5]] - hCdc42 + protein diaphanous homolog 1 + GMPPNP<br />
-**[[3gcg]] - hCdc42 + MAP<br />
-**[[4ltr]] - hCdc42 + AMP-protein transferase<br />
-**[[1nf3]] - hCdc42 + Par6<br />
-**[[2ase]] - hCdc42 (mutant) - NMR<br />
-**[[1ki1]] – hCdc42 + intersectin long form<br />
-**[[1ees]] – hCdc42 + MapK3 peptide - NMR<br />
-**[[1doa]] - hCdc42 + GDP-dissociation inhibitor<br />
-**[[2ngr]] – hCdc42 + GTPase-activating protein C terminal + GDP<br />
-**[[1am4]] – hCdc42 + GTPase-activating protein rhoGAP + GNP<br />
-**[[1grn]] – hCdc42 + GTPase-activating protein rhoGAP + GDP<br />
-**[[1cf4]] – hCdc42 (mutant) + ACK GTPase-binding domain + GNP - NMR<br />
-**[[1cee]] – hCdc42 + WASP GTPase-binding domain + GCP - NMR<br />
-**[[2odb]] – hCdc42 + PAK6 CRIB domain + GCP <br />
-**[[3qbv]] – hCdc42 (mutant) + intersectin + GDP <br />
-**[[4did]] – hCdc42 + inositol phosphate phosphatase + GDP <br />
-**[[1cf4]] – hCdc42 (mutant) + dedicator of cytokinesis protein 8<br />
-**[[4itr]] – hCdc42 + AMP-protein transferase + GDP + AMP<br />
-*'''Rac-like GTP-binding protein'''
-**[[4u5x]] – Arac1 (mutant) + GNPPNP – rice <br />
-**[[2wbl]] – AtArac2 + Rho of plant guanine nucleotide exchange factor 8 – ''Arabidopsis thaliana''<br />
-**[[3bwd]] – AtArac6<br />
-**[[2nty]] – AtArac5 + prone8<br />
-**[[2j0v]] – AtArac7 (mutant)<br />
-*'''Rab-related small GTP-binding protein'''
-**[[2ys8]] – hRabJ DNAJ domain – NMR<br />
-*'''Flagella-associated GTP-binding protein'''
-**[[2px0]] – BsFlhF + GMP-PNP <br />
-**[[2px3]] – BsFlhF + GTP<br />
-*'''Small GTP-binding protein'''
-**[[5kh0]] – GBP – ''Thermotoga neapolitana''<br />
-*'''Small GTP-binding protein ERA'''
-**[[1ega]] – EcERA <br />
-**[[3ieu]] – EcERA + GDP <br />
-**[[3iev]] – AaERA + RNA + Mg-GNP <br />
-**[[1x1l]] – TtERA + RNA – Cryo EM<br />
-**[[1x18]] – TtERA + RNA + RPS2 + RPS7 + RPS11 + RPS18 – Cryo EM<br />
-*'''Small GTP-binding protein Rheb'''
-**[[1xtq]], [[5yxh]] – hRheb + GDP<br />
-**[[1xts]] - hRheb + GTP<br />
-**[[1xtr]] - hRheb + GPPNHP<br />
-**[[3sea]] - hRheb + GDP + GNP<br />
-**[[6bt0]], [[6bsx]] - hRheb + GDP + inhibitor<br />
-**[[3t5g]] – hRheb + GMP-PDE delta<br />
-**[[4o25]] – mRheb + GTP - mouse<br />
-**[[4o2l]] - mRheb (mutant) + GTP <br />
-**[[4o2r]] - mRheb (mutant) + GDP <br />
-**[[3t5g]] – hRheB + GMP-PDE δ<br />
-**[[2l0x]] – rRheb + GDP<br />
-*'''Small GTP-binding protein Gem'''
-**[[2cjw]], [[2ht6]], [[2g3y]] – hGem G domain + GDP<br />
-*'''Small GTP-binding protein Ran'''
-**[[2mmc]], [[2mmg]] – hRan <br />
-*Ran binary complex
-**[[3gj0]], [[5ciw]], [[5cit]], [[5ciq]] – hRan + GDP<br />
-**[[5cj2]] – hRan (mutant) + GDP<br />
-**[[1i2m]] – hRan + regulator of chromosome condensation 1<br />
-**[[1byu]] – Ran + GDP - dog<br />
-**[[1qg2]], [[1qg4]], [[3ran]] – dRan (mutant) + GDP<br />
-**[[2bku]] – dRan + importin<br />
-*Ran ternary complex
-**[[1rrp]] – hRan + Nup358 + GTP analog<br />
-**[[1qbk]] – hRan + karyopherin β2 + GTP analog<br />
-**[[1ibr]] – hRan + importin β1 subunit + GTP analog<br />
-**[[4ol0]] – hRan + importin 12 + GTP<br />
-**[[3ea5]] – hRan (mutant) + importin β1 subunit + GDP <br />
-**[[6q82]] – hRan (mutant) + importin β-like protein + GTP<br />
-**[[4c0q]] - hRan (mutant) + importin 12 + GTP <br />
-**[[3nc1]] – hRan (mutant) + exportin 1 + GTP <br />
-**[[5clq]] – hRan (mutant) + RanBD1 + GNP <br />
-**[[5cll]] – hRan + RanBD1 + GDP <br />
-**[[3ch5]], [[3gj3]], [[3gj4]], [[3gj5]], [[3gj6]], [[3gj7]], [[3gj8]] – hRan + Nup153 + GDP<br />
-**[[3w3z]] – dRan + importin β1 subunit + GTP <br />
-**[[5bxq]] – dRan + NTF-2 + GDP <br />
-*Ran larger complex
-**[[3gjx]] – hRan + snurportin 1 + exportin 1 + GTP <br />
-**[[3nby]], [[3nbz]], [[3nc0]] – hRan (mutant) + snurportin 1 + exportin 1 + GTP <br />
-**[[1k5d]], [[5zpu]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GTP analog<br />
-**[[1k5g]] – hRan + Ran-specific GTPase-activating protein + Ran GTPase activating protein 1 + GDP <br />
-**[[4gpt]], [[4gmx]], [[4hat]], [[4hb2]], [[4hb3]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP <br />
-**[[4hat]], [[4hau]], [[4hav]], [[4haw]], [[4hax]], [[4hay]], [[4haz]], [[4hb0]], [[4hb4]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + antibiotic<br />
-**[[5jlj]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + GNP + inhibitor<br />
-**[[4wvf]] – hRan + Ran-specific GTPase-activating protein + CRM1P + GNP + inhibitor<br />
-**[[6cit]] – hRan + Ran-specific GTPase-activating protein + exportin + NS2<br />
-**[[6a3e]], [[6a3c]], [[6a3b]], [[6a3a]], [[6a38]] – hRan + Ran-specific GTPase-activating protein + exportin + NES + GTP<br />
-**[[5ytb]], [[5yst]], [[5yro]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP<br />
-**[[5ysu]] – hRan (mutant) + Ran-specific GTPase-activating protein + exportin + GTP + plumbagin<br />
-**[[5uww]], [[5uwu]], [[5uwt]], [[5uws]], [[5uwr]], [[5uwq]], [[5uwp]], [[5uwo]], [[5uwj]], [[5uwi]], [[5uwh]], [[5dif]], [[5di9]], [[5dhf]], [[5dha]], [[5dh9]] – hRan + Ran-specific GTPase-activating protein + exportin 1 + peptide<br />
-**[[3zjy]] – hRan (mutant) + importin 13 + EIF-1A + GTP <br />
-**[[6q84]] – hRan (mutant) + importin β-like protein + EIF-4D + GTP<br />
-**[[5dlq]] – hRan (mutant) + exportin 4 + EIF-5A + GTP <br />
-**[[5dis]] – hRan (mutant) + exportin 1 + RNA U transporter + Nup214 + GTP <br />
-**[[3a6p]] – dRan + pre-microRNA + exportin 5 + peptide <br />
-**[[3icq]] – yRan + RNA + exportin T  <br />
-**[[3m1i]] – yRan + Ran-specific GTPase-activating protein + exportin 1 + GTP <br />
-*'''Small GTPase h-Ras''' see [[GTPase HRas]]
-*'''Heterotrimeric G protein see [[Transducin]]'''
-}}
 ==See Also==
 * [[G protein-coupled receptor]]

Revision as of 10:03, 18 July 2019

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E. coli small GTP-binding protein ERA complex with GDP and sulfate (PDB code 3ieu)

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1 Function
2 Disease
3 Relevance
4 Structural highlights
5 3D Structures of GTP-binding protein

Function

GTP-binding proteins or G proteins are transmitting signals outside the cell which cause changes within the cell. They act as molecular switches which are on when binding GTP and off when binding GDP. GTP-binding proteins belong to two families: heterotrimeric G proteins^[1] see Transducin and small GTPases^[2]. The structure of small GTPase is homologous to that of the α subunit of heterotrimeric G protein. See details on small GTP-binding protein LepA in LepA.

Heterotrimeric G protein or guanine nucleotide-binding protein or G protein (GNBP) are heterodimeric membrane proteins composed of α, β and γ subunits. GNBP is involved in mammalian cellular signaling pathways. GNBP α subunit binds GDP or GTP. When bound to GTP it dissociates from the β and γ subunits, binds to adenylate cyclase which converts ATP to cAMP. See also

G protein-coupled receptor
Beta2 adrenergic receptor-Gs protein complex.

Disease

Mutations in heterotrimeric G protein α subunit were identified in endocrine tumors and in McCune-Albright syndrome^[3].

Relevance

Rho-related small GTP-binding protein is inhibited by the antifungal drug Cancidas^[4].

Structural highlights

E. coli small GTPase ERA binds GDP in a cavity formed by ^[5]. . Water molecules are shown as red spheres.

3D Structures of GTP-binding protein

GTP-binding protein 3D structures

References

↑ Preininger AM, Hamm HE. G protein signaling: insights from new structures. Sci STKE. 2004 Jan 27;2004(218):re3. PMID:14762218 doi:http://dx.doi.org/10.1126/stke.2182004re3
↑ Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins. Physiol Rev. 2001 Jan;81(1):153-208. PMID:11152757
↑ Lania A, Mantovani G, Spada A. G protein mutations in endocrine diseases. Eur J Endocrinol. 2001 Nov;145(5):543-59. PMID:11720871
↑ Moreno-Velasquez SD, Seidel C, Juvvadi PR, Steinbach WJ, Read ND. Caspofungin-Mediated Growth Inhibition and Paradoxical Growth in Aspergillus fumigatus Involve Fungicidal Hyphal Tip Lysis Coupled with Regenerative Intrahyphal Growth and Dynamic Changes in beta-1,3-Glucan Synthase Localization. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: AAC.00710-17. doi:, 10.1128/AAC.00710-17. Print 2017 Oct. PMID:28760907 doi:http://dx.doi.org/10.1128/AAC.00710-17
↑ Tu C, Zhou X, Tropea JE, Austin BP, Waugh DS, Court DL, Ji X. Structure of ERA in complex with the 3' end of 16S rRNA: implications for ribosome biogenesis. Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14843-8. Epub 2009 Aug 17. PMID:19706445

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GTP-binding protein

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Revision as of 10:03, 18 July 2019

Contents

Function

Disease

Relevance

Structural highlights

3D Structures of GTP-binding protein

See Also

References

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