Nuclear receptor coactivator
From Proteopedia
(Difference between revisions)
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*'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | *'''NCOA5''' is both a DNA transcription coactivator and corepressor. It interacts with steroid receptor.<br /> | ||
== Structural highlights == | == Structural highlights == | ||
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/7'>NCOA/STAT6 transactivator domain LXXLL peptide interactions</scene>. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/8'>1st Iod coordination site</scene>. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/9'>2nd Iod coordination site</scene>. Water molecules are shown as red spheres. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/10'>3th and 4th Iod coordination sites</scene>. |
| - | *<scene name='49/494427/Cv/ | + | *<scene name='49/494427/Cv/11'>5th Iod coordination site</scene>. |
</StructureSection> | </StructureSection> | ||
Revision as of 14:10, 23 July 2019
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3D structures of nuclear receptor coactivator
1v95 – hNCOA5 – human - NMR
1kbh – hNCOA + CREB-binding protein - NMR
2c52 – hNCOA1 residues 920-970 + CREB-binding protein - NMR
1oj5 – NCOA1A Pas-B domain + signal transducer and activator of transcription peptide - mouse
References
- ↑ Horwitz KB, Jackson TA, Bain DL, Richer JK, Takimoto GS, Tung L. Nuclear receptor coactivators and corepressors. Mol Endocrinol. 1996 Oct;10(10):1167-77. PMID:9121485 doi:http://dx.doi.org/10.1210/mend.10.10.9121485
