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6plg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human PHGDH complexed with Compound 15== | |
| - | + | <StructureSection load='6plg' size='340' side='right'caption='[[6plg]], [[Resolution|resolution]] 2.93Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6plg]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6PLG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6PLG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLT:D-MALATE'>MLT</scene>, <scene name='pdbligand=ONS:(2S)-(4-{3-[(4,5-dichloro-1-methyl-1H-indole-2-carbonyl)amino]oxetan-3-yl}phenyl)(pyridin-3-yl)acetic+acid'>ONS</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6plg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6plg OCA], [http://pdbe.org/6plg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6plg RCSB], [http://www.ebi.ac.uk/pdbsum/6plg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6plg ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/SERA_HUMAN SERA_HUMAN]] Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:[http://omim.org/entry/601815 601815]]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lakshminarasimhan, D]] | ||
| + | [[Category: Olland, A]] | ||
| + | [[Category: Suto, R K]] | ||
| + | [[Category: White, A]] | ||
| + | [[Category: Dehydrogenase]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Oxidoreductase-inhibitor complex]] | ||
| + | [[Category: Serine metabolism]] | ||
Revision as of 06:26, 24 July 2019
Crystal structure of human PHGDH complexed with Compound 15
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