This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6h0s
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6h0s is ON HOLD until Jul 10 2020 Authors: Coste, F., Castaing, B., Carell, T. Description: Crystal structure of the complex between the Lactococcu...) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA== | |
| - | + | <StructureSection load='6h0s' size='340' side='right'caption='[[6h0s]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6h0s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOX:((1R,2S,4R)-4-{[2-AMINO-5-(FORMYLAMINO)-6-OXO-3,6-DIHYDROPYRIMIDIN-4-YL]AMINO}-2-HYDROXYCYCLOPENTYL)METHYL+5-PHOSPHATE'>FOX</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0s OCA], [http://pdbe.org/6h0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0s RCSB], [http://www.ebi.ac.uk/pdbsum/6h0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0s ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/A0A165FVI1_LACLC A0A165FVI1_LACLC]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.[HAMAP-Rule:MF_00103][SAAS:SAAS00020861] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Carell, T]] | ||
[[Category: Castaing, B]] | [[Category: Castaing, B]] | ||
[[Category: Coste, F]] | [[Category: Coste, F]] | ||
| - | [[Category: | + | [[Category: Glycosylase]] |
| + | [[Category: Hydantoin lesion]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protein-dna complex]] | ||
Current revision
Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA
| |||||||||||
