This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6hp8
From Proteopedia
(Difference between revisions)
m (Protected "6hp8" [edit=sysop:move=sysop]) |
|||
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of DPP8 in complex with Val-BoroPro== | |
| - | + | <StructureSection load='6hp8' size='340' side='right'caption='[[6hp8]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6hp8]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HP8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HP8 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GK2:[(2~{R})-1-[(2~{R})-2-azanyl-3-methyl-butanoyl]pyrrolidin-2-yl]boronic+acid'>GK2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hp8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hp8 OCA], [http://pdbe.org/6hp8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hp8 RCSB], [http://www.ebi.ac.uk/pdbsum/6hp8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hp8 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DPP8_HUMAN DPP8_HUMAN]] Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.<ref>PMID:11012666</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dipeptidyl-peptidase IV]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Huber, R]] | [[Category: Huber, R]] | ||
| + | [[Category: Ross, B H]] | ||
| + | [[Category: Dpp8]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Protease]] | ||
| + | [[Category: Val-boropro]] | ||
Current revision
Crystal structure of DPP8 in complex with Val-BoroPro
| |||||||||||
