This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Polyamine oxidase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:26, 12 August 2019) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3l1r| PDB=3l1r | SIZE=400| SCENE= |right|CAPTION=Yeast polyamine oxidase Fms1 complex with spermidine, sulfate and chloride ion, [[3l1r]] }}
+
<StructureSection load='' size='350' side='right' scene='48/486448/Cv/1' caption='lycosylated FAD containing polyamine oxidase dimer complex with spermidine, sulfate and Cl- ion (green), [[3l1r]]' >
-
<!--
+
-
Please use the "3D" button above this box to insert a Jmol applet (molecule) on this page.
+
-
Or use the four-green-boxes-button to insert scrollable text adjacent
+
-
to a Jmol applet. Check out the other buttons as well!
+
-
-->
+
-
'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide. PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death. PAO is involved in polyamine catabolism and uses FAD as a cofactor.
+
 +
 +
'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide. PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death. PAO is involved in polyamine catabolism and uses FAD as a cofactor<ref>PMID:8584670</ref>.
 +
*<scene name='48/486448/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.
 +
*<scene name='48/486448/Cv/5'>Spermidine binding site</scene>.
 +
*<scene name='48/486448/Cv/6'>Whole active site</scene>.
 +
</StructureSection>
==3D structures of polyamine oxidase==
==3D structures of polyamine oxidase==
-
[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br />
+
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-
[[3kpf]] – yPAO (mutant)<br />
+
{{#tree:id=OrganizedByTopic|openlevels=0|
-
[[1b37]], [[1b5q]], [[1h81]] – mPAO FAD-binding domain – maize
+
 
 +
*Polyamine oxidase
 +
 
 +
**[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br />
 +
**[[3kpf]], [[4ech]], [[4gdp]] – yPAO (mutant)<br />
 +
**[[1b37]], [[1b5q]], [[1h81]] – mPAO FAD-binding domain – maize
-
'''Polyamine oxidase binary complex'''
+
*Polyamine oxidase binary complex
-
[[1h82]], [[1h83]], [[1h84]], [[1h86]] – mPAO FAD-binding domain + polyamine<br />
+
**[[1h82]], [[1h83]], [[1h84]], [[1h86]] – mPAO FAD-binding domain + polyamine<br />
-
[[1z6l]] - yPAO + polyamine<br />
+
**[[1z6l]] - yPAO + polyamine<br />
-
[[3bi2]], [[3bi4]], [[3bi5]] – yPAO + inhibitor<br />
+
**[[3bi2]], [[3bi4]], [[3bi5]] – yPAO + inhibitor<br />
-
[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br />
+
**[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br />
-
[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br />
+
**[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br />
-
[[3l1r]] - mPAO (mutant) FAD-binding domain + spermidine
+
**[[3l1r]] - mPAO (mutant) FAD-binding domain + spermidine<br />
 +
**[[3ku9]] - mPAO FAD-binding domain (mutant) + spermine<br />
 +
}}
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

lycosylated FAD containing polyamine oxidase dimer complex with spermidine, sulfate and Cl- ion (green), 3l1r

Drag the structure with the mouse to rotate

3D structures of polyamine oxidase

Updated on 12-August-2019

References

  1. ↑ Seiler N. Polyamine oxidase, properties and functions. Prog Brain Res. 1995;106:333-44. PMID:8584670

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Polyamine_oxidase"
Personal tools