6kbo
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Three-dimensional LPS bound structure of VG16KRKP-KYE28.== | |
| - | + | <StructureSection load='6kbo' size='340' side='right'caption='[[6kbo]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6kbo]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KBO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KBO FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kbo OCA], [http://pdbe.org/6kbo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kbo RCSB], [http://www.ebi.ac.uk/pdbsum/6kbo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kbo ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/HEP2_HUMAN HEP2_HUMAN]] Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10) [MIM:[http://omim.org/entry/612356 612356]]. A hemostatic disorder characterized by a tendency to recurrent thrombosis.<ref>PMID:2647747</ref> <ref>PMID:10391209</ref> <ref>PMID:11204559</ref> <ref>PMID:15337701</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HEP2_HUMAN HEP2_HUMAN]] Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.<ref>PMID:1939083</ref> Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.<ref>PMID:1939083</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bhunia, A]] | ||
| + | [[Category: Ilyas, H]] | ||
| + | [[Category: Antimicrobial peptide]] | ||
| + | [[Category: Antimicrobial protein]] | ||
| + | [[Category: Bacterial membrane]] | ||
| + | [[Category: Nuclear magnetic spectroscopy]] | ||
| + | [[Category: Peptide synergism]] | ||
Revision as of 16:35, 14 August 2019
Three-dimensional LPS bound structure of VG16KRKP-KYE28.
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