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1b8t

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Revision as of 17:46, 14 August 2019

SOLUTION STRUCTURE OF THE CHICKEN CRP1

Structural highlights

1b8t is a 1 chain structure with sequence from Chick. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CSRP1_CHICK] Heat stable protein, that interacts with zyxin. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The mechanism by which the contractile machinery of muscle is assembled and maintained is not well-understood. Members of the cysteine-rich protein (CRP) family have been implicated in these processes. Three vertebrate CRPs (CRP1-3) that exhibit developmentally regulated muscle-specific expression have been identified. All three proteins are associated with the actin cytoskeleton, and one has been shown to be required for striated muscle structure and function. The vertebrate CRPs identified to date display a similar molecular architecture; each protein is comprised of two tandemly arrayed LIM domains, protein-binding motifs found in a number of proteins with roles in cell differentiation. Each LIM domain coordinates two Zn(II) ions that are bound independently in CCHC (C=Cys, H=His) and CCCC modules. Here we describe the solution structure of chicken CRP1 determined by homonuclear and 1H-15N heteronuclear magnetic resonance spectroscopy. Comparison of the structures of the two LIM domains of CRP1 reveals a high degree of similarity in their tertiary folds. In addition, the two component LIM domains represent two completely independent folding units and exhibit no apparent interactions with each other. The structural independence and spatial separation of the two LIM domains of CRP1 are compatible with an adapter or linker role for the protein.

Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation.,Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC Biochemistry. 1999 May 4;38(18):5701-13. PMID:10231520^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Yao X, Perez-Alvarado GC, Louis HA, Pomies P, Hatt C, Summers MF, Beckerle MC. Solution structure of the chicken cysteine-rich protein, CRP1, a double-LIM protein implicated in muscle differentiation. Biochemistry. 1999 May 4;38(18):5701-13. PMID:10231520 doi:http://dx.doi.org/10.1021/bi982036y

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1b8t"

@@ Line 1: / Line 1: @@
-{{Large structure}}
 ==SOLUTION STRUCTURE OF THE CHICKEN CRP1==
-<StructureSection load='1b8t' size='340' side='right' caption='[[1b8t]], [[NMR_Ensembles_of_Models | 37 NMR models]]' scene=''>
+<StructureSection load='1b8t' size='340' side='right'caption='[[1b8t]], [[NMR_Ensembles_of_Models | 37 NMR models]]' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1b8t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Chick Chick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B8T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1B8T FirstGlance]. <br>
@@ Line 7: / Line 7: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1b8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1b8t OCA], [http://pdbe.org/1b8t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1b8t RCSB], [http://www.ebi.ac.uk/pdbsum/1b8t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1b8t ProSAT]</span></td></tr>
 </table>
-{{Large structure}}
 == Function ==
 [[http://www.uniprot.org/uniprot/CSRP1_CHICK CSRP1_CHICK]] Heat stable protein, that interacts with zyxin. May be a component of a signal transduction pathway that mediates adhesion-stimulated changes in gene expression.
@@ Line 14: / Line 13: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8t_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/1b8t_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 34: / Line 33: @@
 </StructureSection>
 [[Category: Chick]]
+[[Category: Large Structures]]
 [[Category: Beckerle, M C]]
 [[Category: Hatt, C]]

1b8t

From Proteopedia

Revision as of 17:46, 14 August 2019

SOLUTION STRUCTURE OF THE CHICKEN CRP1

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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