Ribosomal protein L11 methyltransferase

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[[Image:2nxc.png|left|200px|thumb|Crystal Structure of Apo-form of ''Thermus thermophilus'' ribosomal protein L11 methyltransferase [[2nxc]]]]
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<StructureSection load='' size='350' side='right' caption='Structure of ribosomal protein L11 methyltransferase (deepskyblue) complex with 50S ribosomal protein L11 (green) (PDB entry [[2nxn]])' scene='42/423383/Cv/2'>
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{{STRUCTURE_2nxc| PDB=2nxc | SIZE=300| SCENE= |right|CAPTION=Apo-form of ''Thermus thermophilus'' ribosomal protein L11 methyltransferase [[2nxc]] }}
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== Function ==
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[[Ribosomal protein L11 methyltransferase]] (L11 MTase) catalyzes the methylation of ribosomal protein L11 (RPL11)<ref>PMID:10997488</ref>.
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[[Ribosomal protein L11 methyltransferase]] (L11 MTase) catalyzes the methylation of ribosomal protein L11 (RPL11). The images at the left and at the right correspond to one representative L11 MTase, ''i.e.'' the crystal structure of Apo-form of ''Thermus thermophilus'' ribosomal protein L11 methyltransferase ([[2nxc]]).
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== Structural highlights ==
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L11 MTase methylates the <scene name='42/423383/Cv/4'>N terminal of RPL11 and residues Lys3 and Lys39</scene>.<ref>PMID:17215866</ref>
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</StructureSection>
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{{TOC limit|limit=2}}
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== 3D Structures of Ribosomal protein L11 methyltransferase ==
== 3D Structures of Ribosomal protein L11 methyltransferase ==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*Ribosomal protein L11 methyltransferase
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L11 MTase
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**[[3grz]] – L11 MTase C-terminal – ''Lactobacillus delbruekii''<br />
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**[[2nxc]], [[2nxj]] - TtL11 MTase - ''Thermus thermophilus''<br />
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**[[2zbp]], [[2zbq]], [[2zbr]], [[2nxe]]– TtL11 MTase+S-adenosyl derivatives <br />
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**[[5fa8]] - SiL11 MTase + SAM - ''Sulfolobus islandicus''<br />
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**[[5fad]] - SiL11 MTase + SAH <br />
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3grz – L11 MTase C-terminal – Lactobacillus delbruekii
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*Ribosomal protein L11 methyltransferase+Ribosomal protein L11
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2nxc, 2nxj - TtL11 MTase - Thermus thermophilus
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2zbp, 2zbq, 2zbr , 2nxe– TtL11 MTase+S-adenosyl derivatives
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L11 Mtase+RPL11
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**[[3egv]], [[2nxn]] – TtL11 Mtase+RPL11<br />
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**[[3cjq]] - TtL11 Mtase+RPL11 (mutant)<br />
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3egv, 2nxn – TtL11 Mtase+RPL11
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**[[3cjr]] - TtL11 Mtase+RPL11 (mutant)+sinefungin<br />
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3cjq - TtL11 Mtase+RPL11 (mutant)
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**[[3cjs]] - TtL11 Mtase N-terminal+RPL11 N-terminal<br />
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3cjr - TtL11 Mtase+RPL11 (mutant)+sinefungin
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**[[3cjt]] - TtL11 Mtase (mutant)+RPL11<br />
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3cjs - TtL11 Mtase N-terminal+RPL11 N-terminal
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}}
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3cjt - TtL11 Mtase (mutant)+RPL11
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== References ==
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<references/>
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[[Category:Topic Page]]

Current revision

Structure of ribosomal protein L11 methyltransferase (deepskyblue) complex with 50S ribosomal protein L11 (green) (PDB entry 2nxn)

Drag the structure with the mouse to rotate

3D Structures of Ribosomal protein L11 methyltransferase

References

  1. ↑ Bujnicki JM. Sequence, structural, and evolutionary analysis of prokaryotic ribosomal protein L11 methyltransferases. Acta Microbiol Pol. 2000;49(1):19-29. PMID:10997488
  2. ↑ Demirci H, Gregory ST, Dahlberg AE, Jogl G. Recognition of ribosomal protein L11 by the protein trimethyltransferase PrmA. EMBO J. 2007 Jan 24;26(2):567-77. Epub 2007 Jan 11. PMID:17215866

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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