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Selectin

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== Structural insight ==
== Structural insight ==
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The <scene name='55/552185/Cv/2'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/3'>Ca coordination site</scene>.
+
The <scene name='55/552185/Cv/4'>tetrasaccharide binding interactions to P-selectin are electrostatic</scene><ref>PMID:11081633</ref>. <scene name='55/552185/Cv/5'>Ca coordination site</scene>.
</StructureSection>
</StructureSection>

Revision as of 13:46, 2 September 2019

Structure of P-selectin EGF domain complex with tetrasaccharide and Ca+2 ion (green) (PDB entry 1g1r)

Drag the structure with the mouse to rotate

3D structures of selectin

Updated on 02-September-2019

References

  1. Tedder TF, Steeber DA, Chen A, Engel P. The selectins: vascular adhesion molecules. FASEB J. 1995 Jul;9(10):866-73. PMID:7542213
  2. Ley K. The role of selectins in inflammation and disease. Trends Mol Med. 2003 Jun;9(6):263-8. PMID:12829015
  3. Szepietowski J, Wasik F, Bielicka E, Nockowski P, Noworolska A. Soluble E-selectin serum levels correlate with disease activity in psoriatic patients. Clin Exp Dermatol. 1999 Jan;24(1):33-6. PMID:10233646
  4. Kretowski A, Gillespie KM, Bingley PJ, Kinalska I. Soluble L-selectin levels in type I diabetes mellitus: a surrogate marker for disease activity? Immunology. 2000 Feb;99(2):320-5. PMID:10692053
  5. Somers WS, Tang J, Shaw GD, Camphausen RT. Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1. Cell. 2000 Oct 27;103(3):467-79. PMID:11081633

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Michal Harel, Alexander Berchansky

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