This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5lvo
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket== | ==Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket== | ||
| - | <StructureSection load='5lvo' size='340' side='right' caption='[[5lvo]], [[Resolution|resolution]] 1.09Å' scene=''> | + | <StructureSection load='5lvo' size='340' side='right'caption='[[5lvo]], [[Resolution|resolution]] 1.09Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5lvo]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LVO FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5lvo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LVO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LVO FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78W:2-OXIDANYLIDENEPROPYL+~{N}-(2-CHLORANYL-6-FLUORANYL-PHENYL)CARBONYL-~{N}-(4-CHLOROPHENYL)CARBAMIMIDOTHIOATE'>78W</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=78W:2-OXIDANYLIDENEPROPYL+~{N}-(2-CHLORANYL-6-FLUORANYL-PHENYL)CARBONYL-~{N}-(4-CHLOROPHENYL)CARBAMIMIDOTHIOATE'>78W</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDPK1, PDK1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lvo OCA], [http://pdbe.org/5lvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lvo RCSB], [http://www.ebi.ac.uk/pdbsum/5lvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lvo ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lvo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lvo OCA], [http://pdbe.org/5lvo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lvo RCSB], [http://www.ebi.ac.uk/pdbsum/5lvo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lvo ProSAT]</span></td></tr> | ||
| Line 22: | Line 23: | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Pdk1 3D structures|Pdk1 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Non-specific serine/threonine protein kinase]] | [[Category: Non-specific serine/threonine protein kinase]] | ||
[[Category: Alzari, P M]] | [[Category: Alzari, P M]] | ||
Revision as of 06:31, 16 October 2019
Human PDK1 Kinase Domain in Complex with Allosteric Compound PSE10 Bound to the PIF-Pocket
| |||||||||||
Categories: Human | Large Structures | Non-specific serine/threonine protein kinase | Alzari, P M | Biondi, R M | Busschots, K | Gervasio, F L | Herbrand, A K | Hindie, V | Lisa, M N | Neimanis, S | Odadzic, D | Saladino, G | Schulze, J O | Suess, E | Zeuzem, S | Allosteric regulation | Pif-pocket | Protein kinase | Small compound | Transferase
