Leukotriene B4 hydroxydehydrogenase

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[[Image:1zsv.png|left|200px|thumb|Crystal Structure of Leukotriene B4 hydroxydehydrogenase ([[1zsv]])]]
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<StructureSection load='' size='450' side='right' caption='Guinea pig leukotriene B4 12-hydroxydehydrogenase complex with oxo-PGE2, NADP an Cl- ion (green)(PDB entry [[1v3v]])' scene='43/433641/Cv/2'>
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{{STRUCTURE_1zsv| PDB=1zsv | SIZE=400| SCENE=Leukotriene_B4_hydroxydehydrogenase/Cv/1 |right|CAPTION=Leukotriene B4 hydroxydehydrogenase complex with Cl- ions [[1zsv]]}}
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== Function ==
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'''Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin reductase''' (LB4H) is a bifunctional enzyme. It is part of the arachidonic acid cycle and is part of the metabolism of prostaglandins, leukotriene B4 and lipoxin. LB4H is an NADP-dependent enzyme.
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== Relevance ==
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LB4H 1 restricts inflammation and confers resistance to tuberculosis infection<ref>PMID:23874453</ref>.
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== Structural highlights ==
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<scene name='43/433641/Cv/7'>LB4H active site is located at the hydrophobic pore</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}) on the dimer interface<ref>PMID:15007077</ref>. <scene name='43/433641/Cv/8'>Pore</scene>.
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</StructureSection>
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== Structural highlights ==
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[[Leukotriene B4 hydroxydehydrogenase]] (LB4H) is part of the arachidonic acid cycle and is involved in inflammation. The images at the left and at the right correspond to one representative LB4H, ''i.e.'' the crystal structure of human Leukotriene B4 hydroxydehydrogenase ([[1zsv]]).
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== 3D Structures of Leukotriene B4 hydroxydehydrogenase ==
== 3D Structures of Leukotriene B4 hydroxydehydrogenase ==
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[[1v3t]], [[1v3u]] - gpLB4H/15-oxo-prostaglandin 13-reductase<br />
[[1v3t]], [[1v3u]] - gpLB4H/15-oxo-prostaglandin 13-reductase<br />
[[1v3v]] - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2<br />
[[1v3v]] - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Guinea pig leukotriene B4 12-hydroxydehydrogenase complex with oxo-PGE2, NADP an Cl- ion (green)(PDB entry 1v3v)

Drag the structure with the mouse to rotate

Structural highlights

3D Structures of Leukotriene B4 hydroxydehydrogenase

1zsv – LB4H - human
2dm6 –gpLB4H/15-oxo-prostaglandin 13-reductase+indomethacin – guinea pig
1v3t, 1v3u - gpLB4H/15-oxo-prostaglandin 13-reductase
1v3v - gpLB4H/15-oxo-prostaglandin 13-reductase+NADP+15-oxo-PGE-2

References

  1. ↑ Tobin DM, Roca FJ, Ray JP, Ko DC, Ramakrishnan L. An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. PLoS One. 2013 Jul 11;8(7):e67828. doi: 10.1371/journal.pone.0067828. Print 2013. PMID:23874453 doi:http://dx.doi.org/10.1371/journal.pone.0067828
  2. ↑ Hori T, Yokomizo T, Ago H, Sugahara M, Ueno G, Yamamoto M, Kumasaka T, Shimizu T, Miyano M. Structural basis of leukotriene B4 12-hydroxydehydrogenase/15-Oxo-prostaglandin 13-reductase catalytic mechanism and a possible Src homology 3 domain binding loop. J Biol Chem. 2004 May 21;279(21):22615-23. Epub 2004 Mar 8. PMID:15007077 doi:10.1074/jbc.M312655200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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