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6kty

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Revision as of 07:57, 23 October 2019

Crystal structure of the flagellar cap protein FliD from Bdellovibrio bacteriovorus

Structural highlights

6kty is a 1 chain structure with sequence from Bdeba. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	fliD, Bd0610 (BDEBA)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[Q6MQ71_BDEBA] Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.[RuleBase:RU362066]

Publication Abstract from PubMed

Bdellovibrio bacteriovorus is a predator bacterial species of the Deltaproteobacteria class that requires flagellum-mediated motility to initiate the parasitization of other gram-negative bacteria. The flagellum is capped by FliD, which polymerizes flagellin into a flagellar filament. FliD has been reported to function as a species-specific oligomer, such as a tetramer, a pentamer, or a hexamer, in members of the Gammaproteobacteria class. However, the oligomeric state and structural features of FliD from bacterial species outside the Gammaproteobacteria class are unknown. Based on structural and biochemical analyses, we report here that B. bacteriovorus FliD (bbFliD) forms a tetramer. bbFliD tetramerizes in a circular head-to-tail arrangement by inserting the D2 domain of one subunit into the concave surface of the second subunit generated between the D2 and D3 domains as observed in Serratia marcescens FliD. However, bbFliD adopts a more compact and flat oligomeric structure, which exhibits a more extended tetramerization interface flanked by two additional surfaces due to different intersubunit and interdomain organizations as well as an elongated loop. In conclusion, FliD from B. bacteriovorus, which belongs to the Deltaproteobacteria class, also produces a tetramer similar to FliD from Gammaproteobacterial species but adopts a unique species-specific oligomeric structure.

Crystal structure of the flagellar cap protein FliD from Bdellovibrio bacteriovorus.,Cho SY, Song WS, Yoon SI Biochem Biophys Res Commun. 2019 Nov 12;519(3):652-658. doi:, 10.1016/j.bbrc.2019.09.024. Epub 2019 Sep 18. PMID:31542231^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Cho SY, Song WS, Yoon SI. Crystal structure of the flagellar cap protein FliD from Bdellovibrio bacteriovorus. Biochem Biophys Res Commun. 2019 Nov 12;519(3):652-658. doi:, 10.1016/j.bbrc.2019.09.024. Epub 2019 Sep 18. PMID:31542231 doi:http://dx.doi.org/10.1016/j.bbrc.2019.09.024

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6kty"

@@ Line 3: / Line 3: @@
 <StructureSection load='6kty' size='340' side='right'caption='[[6kty]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6kty]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KTY FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6kty]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bdeba Bdeba]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KTY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6KTY FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kty OCA], [http://pdbe.org/6kty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kty RCSB], [http://www.ebi.ac.uk/pdbsum/6kty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kty ProSAT]</span></td></tr>
+</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fliD, Bd0610 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=264462 BDEBA])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6kty FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6kty OCA], [http://pdbe.org/6kty PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6kty RCSB], [http://www.ebi.ac.uk/pdbsum/6kty PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6kty ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Bdeba]]
 [[Category: Large Structures]]
 [[Category: Cho, S Y]]

6kty

From Proteopedia

Revision as of 07:57, 23 October 2019

Crystal structure of the flagellar cap protein FliD from Bdellovibrio bacteriovorus

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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