Mandelate racemase/muconate lactonizing enzyme
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='340' side='right' caption='MRMLP complex with D-mannonate and Mg+2 ion (green) (PDB code [[2qjm]])' scene='77/775266/Cv/1'> |
| - | with D-mannonate and Mg ion (green) (PDB code [[2qjm]])' scene=''> | + | |
== Function == | == Function == | ||
| - | '''Mandelate racemase/muconate lactonizing enzyme''' (MRMLP) is an enolase family dipeptide epimerase. | + | '''Mandelate racemase/muconate lactonizing enzyme''' (MRMLP) is an enolase family dipeptide epimerase. Other members of th family are '''D-mannonate dehydratase, L-talarate dehydratase, L-rhamnonate dehydratase, D-glucarate dehydratase, Galacturonate dehydratase, Tartarate dehydratase, L-fuconate dehydratase''' and '''N-succinyl Arg/Lys racemate'''. The D-mannonate dehydratase catalyzes the syn-hydration of D-mannonate. |
| - | == | + | == Structural highlights == |
| - | == | + | The D-mannonate dehydratase has <scene name='77/775266/Cv/9'>two domains</scene>: the <scene name='77/775266/Cv/10'>N-terminal α+β domain</scene> and a <scene name='77/775266/Cv/11'>(β/α)<sub>7</sub> β-barrel domain</scene>. The <scene name='77/775266/Cv/12'>active site</scene> of the enzyme is found between these two domains<ref>PMID:179444491</ref>. Water molecules are shown as red spheres. <scene name='77/775266/Cv/13'>Mg coordination site</scene>. |
| - | == | + | == 3D Structures of Mandelate racemase/muconate lactonizing enzyme == |
| + | [[Mandelate racemase/muconate lactonizing enzyme 3D structures]] | ||
</StructureSection> | </StructureSection> | ||
| - | == 3D Structures of Mandelate racemase/muconate lactonizing enzyme == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *Mandelate racemate/muconate lactonizing enzyme | ||
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| - | **[[3mqt]], [[3sjn]] – MRMLP – ''Shewanella pealeana''<br /> | ||
| - | **[[3msy]], [[4h83]], [[3no1]] – MRMLP – ''Actinobacterium''<br /> | ||
| - | **[[3ssz]] – MRMLP – ''Rhodobacteraceae bacterium''<br /> | ||
| - | **[[3t4w]] – MRMLP – ''Sulfitobacter''<br /> | ||
| - | **[[3u9i]] – MRMLP – ''Roseiflexus''<br /> | ||
| - | **[[3ik4]] – MRMLP – ''Herpetosiphon aurantiacus''<br /> | ||
| - | **[[2gdq]], [[2gge]] – MRMLP – ''Bacillus subtilis''<br /> | ||
| - | **[[2og9]], [[3bjs]] – PoMRMLP – ''Polaromonas''<br /> | ||
| - | **[[2pmq]], [[2rdx]], [[3u4f]], [[2qdd]], [[3fvd]] – MRMLP – ''Roseovarius''<br /> | ||
| - | **[[3tmq]] – MRMLP (mutant) – ''Hoeflea phototrophica''<br /> | ||
| - | **[[4j3z]] – MRMLP – ''Jannaschia''<br /> | ||
| - | **[[2qde]] – MRMLP – ''Azoarcus''<br /> | ||
| - | **[[3n4e]], [[4dwd]], [[4e8g]] – PdMRMLP – ''Paracoccus dentrificans''<br /> | ||
| - | **[[4dx3]], [[4dxk]] – AtMRMLP – ''Agrobacterium tumefaciens''<br /> | ||
| - | **[[3toy]] – BrMRMLP – ''Bradyrhizobium''<br /> | ||
| - | **[[3bsm]], [[3ow1]], [[3pk7]] – CsMRMLP – ''Chromohalobacter salexigens''<br /> | ||
| - | **[[1wue]] – MRMLP – ''Enterococcus faecalis''<br /> | ||
| - | **[[4hnl]] – MRMLP – ''Enterococcus gallinarum''<br /> | ||
| - | **[[3tji]] – MRMLP – ''Enterobacter''<br /> | ||
| - | **[[2pod]] – MRMLP – ''Burkholderia pseudomallei''<br /> | ||
| - | **[[2qjj]] – NaMRMLP – ''Novosphignobium aromaticivorans''<br /> | ||
| - | **[[4k8g]] – NaMRMLP (mutant) <br /> | ||
| - | **[[3vc5]], [[3vc6]], [[3vcc]], [[4dhg]] – MRMLP – ''Thermobispora bispora''<br /> | ||
| - | **[[3r25]] – VbMRMLP – ''Vibrionales bacterium'' <br /> | ||
| - | **[[3v5c]], [[3v5f]] – GeMRMLP (mutant) - ''Geobacillus''<br /> | ||
| - | **[[2oz3]] – AvMRMLP – ''Azotobacter vinelandii''<br /> | ||
| - | **[[2p88]] – BcMRMLP – ''Bacillus cereus''<br /> | ||
| - | **[[4fi4]], [[3vcn]] – CcMRMLP - ''Caulobacter crescentus''<br /> | ||
| - | **[[3thu]] – MRMLP - ''Sphigomonas''<br /> | ||
| - | **[[4ip4]] – SiMRMLP - ''Silicibacter''<br /> | ||
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| - | *Mandelate racemate/muconate lactonizing enzyme complex | ||
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| - | **[[3tte]] – BrMRMLP + mandelate <br /> | ||
| - | **[[2qjn]] – NaMRMLP + gluconate derivative <br /> | ||
| - | **[[2qjm]], [[4k1w]] – NaMRMLP (mutant) + D-mannonate <br /> | ||
| - | **[[4gme]] – CcMRMLP + D-mannonate <br /> | ||
| - | **[[4h2h]] – MRMLP + betonicine – ''Pelagibaca bermudensis''<br /> | ||
| - | **[[4j1o]], [[4izg]] – PdMRMLP + betonicine<br /> | ||
| - | **[[3cb3]] – PoMRMLP + glucarate <br /> | ||
| - | **[[3p0w]] – MRMLP + glucarate – ''Ralstonia solanacearum''<br /> | ||
| - | **[[3ekg]] – AvMRMLP + tartrate <br /> | ||
| - | **[[3p3b]] – GeMRMLP + tarrate <br /> | ||
| - | **[[3qpe]] – GeMRMLP + galacturonate <br /> | ||
| - | **[[3qke]] – CsMRMLP + gluconate <br /> | ||
| - | **[[3p93]] – CsMRMLP + gluconate + mannonate<br /> | ||
| - | **[[4kem]] – MRMLP + acrylate – ''Azospirillum''<br /> | ||
| - | **[[2p8b]] – BcMRMLP + N-succinyl Lys <br /> | ||
| - | **[[2p8c]] – BcMRMLP + N-succinyl Arg <br /> | ||
| - | **[[3sbf]] – VbMRMLP + arabinonate <br /> | ||
| - | **[[4gfi]] – AtMRMLP + dipeptide <br /> | ||
| - | **[[3q45]], [[3q4d]] – MRMLP + dipeptide – ''Cytophaga hutchinsonii'' <br /> | ||
| - | **[[4ip5]] – SiMRMLP + erythronohydroxamate <br /> | ||
| - | }} | ||
== References == | == References == | ||
Current revision
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