This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Monooxygenase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:17, 3 November 2019) (edit) (undo)
 
Line 1: Line 1:
<StructureSection load='5tkh' size='350' side='right' scene='' caption='Glycosylated lytic polysaccharide monooxygenase complex with Cu(II) (orange) and peroxide (PDB code [[5tkh]])' >
<StructureSection load='5tkh' size='350' side='right' scene='' caption='Glycosylated lytic polysaccharide monooxygenase complex with Cu(II) (orange) and peroxide (PDB code [[5tkh]])' >
-
 
+
__TOC__
== Function ==
== Function ==
Line 14: Line 14:
</StructureSection>
</StructureSection>
- 
-
==3D structures of monooxygenase==
 
- 
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 
-
{{#tree:id=OrganizedByTopic|openlevels=0|
 
- 
-
*'''Toluene 4-monooxygenase (TMO)'''
 
- 
-
**[[3dhg]], [[3i5j]], [[2inc]] – PmTMO α+β+γ subunits + Fe – ''Pseudomonas mendocina''<br />
 
-
**[[2ind]] – PmTMO α+β+γ subunits + Mn <br />
 
-
**[[3rng]], [[3rnf]], [[3rne]], [[3rnc]], [[3rnb]], [[3rna]], [[3rn9]], [[3n20]], [[3n1z]], [[3n1y]], [[3n1x]], [[2rdb]] – PmTMO α+β+γ subunits (mutant) + Fe <br />
 
-
**[[1sjg]] – PmTMO protein C + Fe <br />
 
-
**[[1vm9]] – PmTMO protein C (mutant) + Fe <br />
 
-
**[[2bf5]], [[2bf3]], [[2bf2]] – PmTMO protein D <br />
 
-
**[[4wqm]] – PmTMO (mutant) + Ni <br />
 
-
**[[4p1c]], [[4p1b]] – PmTMO protein A+B+E+ferredoxin (mutant) + Fe <br />
 
-
**[[2q3w]] – PmTMO ferredoxin subunit (mutant) + Fe <br />
 
- 
-
*TMO complexes
 
- 
-
**[[3dhh]], [[3q3n]], [[3q3o]] – PmTMO α+β+γ subunits + Fe + phenol derivative + TMO system effector protein<br />
 
-
**[[3rmk]], [[1t0s]], [[1t0q]] – PmTMO α+β+γ subunits + Fe + phenol derivative<br />
 
-
**[[3q14]] – PmTMO α+β+γ subunits + Fe + p-cresol + TMO system effector protein<br />
 
-
**[[3q2a]], [[3q3m]] – PmTMO α+β+γ subunits + Fe + benzoate inhibitor + TMO system effector protein<br />
 
-
**[[3dhi]] – PmTMO α+β+γ subunits + Fe + TMO system effector protein<br />
 
-
**[[3ge3]], [[3ge8]], [[3ri7]] – PmTMO α (mutant)+β+γ subunits + Fe + TMO system effector protein<br />
 
-
**[[3i63]] – PmTMO α+β+γ subunits + Fe + TMO system effector protein + H2O2<br />
 
-
**[[5tdv]] – PmTMO protein A+B+D+E + Fe + peroxide<br />
 
-
**[[5tdu]] – PmTMO protein A+B+D+E + Fe + cresol<br />
 
-
**[[5tdt]] – PmTMO protein A+B+D+E + Fe + peroxide + toluene<br />
 
-
**[[5tds]] – PmTMO protein A+B+D+E + Fe + toluene<br />
 
-
**[[1t0r]] – PsTMO + Fe + OH – ''Pseudomonas stutzeri''<br />
 
- 
-
*'''Heme-degrading monooxygenase (IsdI)'''
 
- 
-
**[[2zdp]] – SaIsdI + heme-Co – ''Staphylococcus aureus''<br />
 
-
**[[3lgm]], [[2zdo]] – SaIsdI + heme-Fe<br />
 
-
**[[4fnh]] – SaIsdI (mutant) + heme-Fe<br />
 
-
**[[3lgn]] – SaIsdI + heme-Fe + O2<br />
 
-
**[[3qgp]] – SaIsdI + heme-Fe + CN<br />
 
-
**[[4fni]] – SaIsdI (mutant) + heme-Fe + CN<br />
 
-
**[[4nl5]] – MtMO + heme + CN – ''Mycobacterium tuberculosis''<br />
 
-
**[[4oz5]] – MO + heme – ''Bacillus subtilis''<br />
 
- 
-
*'''Kynurenine 3-monooxygenase (KMO)'''
 
- 
-
**[[5x68]] – hKMO + FAD - human<br />
 
-
**[[4j2w]], [[4j31]], [[4j33]], [[4j34]] – yKMO + FAD – yeast<br />
 
-
**[[4j36]], [[5x64]] – yKMO + FAD + inhibitor<br />
 
-
**[[5x6q]] – yKMO (mutant) + FAD + inhibitor<br />
 
-
**[[5na5]], [[5x6p]] – PfKMO (mutant) + FAD – ''Pseudomonas fluorescens''<br />
 
-
**[[5y7a]], [[5y77]], [[6fox]] – PfKMO + FAD + kynurenine <br />
 
-
**[[5nak]] – PfKMO (mutant) + FAD + kynurenine <br />
 
-
**[[5y66]] – PfKMO + FAD + kynurenine + inhibitor<br />
 
-
**[[6fph]], [[6fp1]], [[6fp0]], [[6foz]], [[6foy]] – PfKMO + FAD + inhibitor<br />
 
-
**[[5nah]], [[5nag]], [[5nae]], [[5nab]], [[5n7t]], [[5mzk]], [[5mzi]], [[5mzc]], [[5fn0]] – PfKMO (mutant) + FAD + inhibitor<br />
 
- 
-
*'''Phenol 2-monooxygenase (PMO)'''
 
- 
-
**[[1foh]] – TcPMO + FAD – ''Trichosporon cutaneum''<br />
 
-
**[[1pn0]] – TcPMO + FAD + phenol<br />
 
- 
-
*'''Phenylalanine 2-monooxygenase'''
 
- 
-
**[[5pah]], [[6pah]] – hFMO catalytic domain + inhibitor <br />
 
- 
-
*Phenylalanine 4-monooxygenase or phenylalanine-4-hydroxylase
 
- 
-
See [[Hydroxylase]]
 
- 
-
*'''ActVA-Orf6 monooxygenase (AOMO)'''
 
- 
-
**[[1lq9]] – ScAOMO – ''Streptomyces coelicolor''<br />
 
-
**[[1n5q]] – ScAOMO + sancycline <br />
 
-
**[[1n5s]], [[1n5t]] – ScAOMO + acetyl dithranol<br />
 
-
**[[1n5v]] – ScAOMO + nanaomycine <br />
 
- 
-
*Baeyer-Villiger monooxygenase (BVMO)
 
- 
-
**[[6jdk]] – BVMO – ''Parvibaculum lavamentivorans''<br />
 
- 
-
*'''Flavin-containing monooxygenase'''
 
- 
-
**[[2gv8]] – fyMO + FAD + NADP – fission yeast<br />
 
-
**[[2gvc]] – fyMO + FAD + NADP + methimazole<br />
 
-
**[[4a9w]] – SmMO + FAD – ''Stenotrophomonas maltophilia''<br />
 
-
**[[4c5o]] – SmMO (mutant) + FAD <br />
 
-
**[[5wan]] – EcMO + FMN + uracil – Escherichia coli<br />
 
-
**[[5iq4]], [[5iq1]], [[5ipy]] – RnMO (mutant) + FAD + NAP – ''Roseovarius nubinhibens'' <br />
 
-
**[[5gsn]] – RnMO (mutant) + FAD + NAP + methimazole <br />
 
-
**[[4usr]] – PsMO + FAD <br />
 
-
**[[3rp6]] – KpMO + FAD – ''Klebsiella pneumoniae''<br />
 
-
**[[3rp8]] – KpMO (mutant) + FAD <br />
 
-
**[[3rp7]] – KpMO + FAD + uric acid<br />
 
-
**[[3c96]], [[2rgj]] – PaMO + FAD – ''Pseudomonas aeruginosa''<br />
 
-
**[[2xvf]], [[2xve]] – MaMO + FAD – ''Methylophaga aminisulfidivorans'' <br />
 
-
**[[2xvj]] – MaMO (mutant) + FAD + indole <br />
 
-
**[[2xvi]] – MaMO (mutant) + FAD + O2<br />
 
-
**[[2vqb]] – MaMO (mutant) + FAD + NADP + O2<br />
 
-
**[[2xvh]], [[2xlu]], [[2xlt]] – MaMO + FAD + NADP derivative<br />
 
-
**[[2xls]], [[2xlr]], [[2xlp]], [[2vq7]] – MaMO (mutant) + FAD + NADP <br />
 
-
**[[5nmw]] – ZvMO + FAD – ''Zonocerus variegatus''<br />
 
-
**[[5nmx]] – ZvMO + FAD + NADP <br />
 
- 
-
*2,4,6-trichlorophenol 4-monooxygenase
 
- 
-
**[[4g5e]] – MO – ''Cupriavidus necator''<br />
 
- 
-
*Chlorophenol 4-monooxygenase
 
- 
-
**[[4oo2]] – MO – ''Streptomyces globisporus''<br />
 
-
**[[3k86]], [[3hwc]] – BcMO – ''Burkholderia cepacia'' <br />
 
-
**[[3k87]] – BcMO + FAD <br />
 
-
**[[3k88]] – BcMO + FAD + NAD <br />
 
- 
-
*Phenylacetone monooxygenase
 
- 
-
**[[4ovi]], [[4c74]] – TfMO + FAD + APADP – ''Thermobifida fusca''<br />
 
-
**[[1w4x]] – TfMO + FAD<br />
 
-
**[[2ylt]], [[2yls]], [[2ylr]] – TfMO + FAD + NADP <br />
 
-
**[[2ylz]] – TfMO (mutant) + FAD <br />
 
-
**[[4c77]] – TfMO (mutant) + FAD + APADP <br />
 
-
**[[4d04]] – TfMO (mutant) + FAD + NAP <br />
 
-
**[[4d03]], [[2ym2]], [[2ylx]], [[2ylw]] – TfMO (mutant) + FAD + NADP <br />
 
-
**[[2ym1]] – TfMO (mutant) + FAD + NADP + O2<br />
 
- 
-
*6-hydroxynicotinate 3-monooxygenase
 
- 
-
**[[5eow]] – PpMO + FAD – ''Pseudomonas putida''<br />
 
- 
-
*Styrene monooxygenase
 
- 
-
**[[3ihm]] – PpMO <br />
 
-
**[[4f07]] – PpMO (mutant) + FAD <br />
 
- 
-
*Tryptophan 2-monooxygenase
 
- 
-
**[[4iv9]] – MO + FAD – ''Pseudomonas savastanoi''<br />
 
- 
-
*Tryptophan 5-monooxygenase
 
- 
-
**[[1mlw]] – hMO + Fe + dihydrobiopterin <br />
 
- 
-
*Tyrosine 3-monooxygenase
 
- 
-
**[[2xsn]] – hMO + Zn<br />
 
-
**[[2toh]] – rMO + Fe + dihydrobiopterin + tyrosine - rat<br />
 
-
**[[2mda]] – rMO regulatory domain <br />
 
- 
-
*Nitronate monooxygenase
 
- 
-
**[[4q4k]] – PaMO + FMN <br />
 
-
**[[6e2a]] – PaMO + FMN + NAD<br />
 
-
**[[5lsm]] – MO + FMN – ''Shewanella oneidensis''<br />
 
-
**[[6bka]] – MO + FMN – ''Cyberlyndnera mrakii''<br />
 
- 
-
*2-hydroxbiphenyl 3-monooxygenase
 
- 
-
**[[4z2r]] – PnMO + FAD – ''Pseudomonas nitroreducens''<br />
 
-
**[[4cy6]] – PnMO (mutant) <br />
 
-
**[[4z2u]], [[4z2t]], [[4cy8]] – PnMO (mutant) + FAD <br />
 
-
**[[5brt]] – PnMO + FAD + hydroxybephenyl <br />
 
- 
-
*4-hydroxyphenylacetate 3-monooxygenase
 
- 
-
**[[4ira]] – BmMO + FAD – ''Brucella melitensis''<br />
 
-
**[[3cb0]] – BmMO + FMN<br />
 
-
**[[6eb0]] – EcMO oxygenase subunit<br />
 
-
**[[6b1b]] – EcMO oxygenase subunit (mutant)<br />
 
- 
-
*Ornithine N(5)-monooxygenase
 
- 
-
**[[5cku]] – MO + FAD + NADP + ornithine – ''Neosartorya fumigata''<br />
 
-
**[[4nzh]], [[4b69]] – AfMO + FAD + ornithine – ''Aspergillus fumigatus''<br />
 
-
**[[4b65]] – AfMO + FAD + NADP <br />
 
-
**[[4b68]], [[4b66]] – AfMO + FAD + NAP + arginine <br />
 
-
**[[4b67]], [[4b63]] – AfMO + FAD + NADP + ornithine <br />
 
-
**[[4b64]] – AfMO + FAD + NADP + lysine <br />
 
-
**[[3s61]] – PaMO + FAD + NADP + ornithine derivative<br />
 
- 
-
*Steroid monooxygenase
 
- 
-
**[[4ap1]], [[4aos]] – RrMO + FAD + NADP – ''Rhodococcus rhodochrous''<br />
 
-
**[[4aox]] – RrMO (mutant) + FAD <br />
 
-
**[[4ap3]] – RrMO (mutant) + FAD + NADP <br />
 
- 
-
*Cyclohexanone monooxygenase
 
- 
-
**[[5m10]] – TmMO + FAD + NAP + nicotinamide – ''Thermocripsum municipale''<br />
 
-
**[[5m0z]] – TmMO + FAD + NADP derivative <br />
 
-
**[[6gqi]] – TmMO + FAD + NADP + hexanic acid <br />
 
-
**[[6era]], [[6er9]] – RhMO + FAD + NADP – ''Rhodococcus''<br />
 
-
**[[4rg4]], [[4rg3]], [[3gwf]], [[3gwd]] – RhMO + FAD + NAP + caprolactone <br />
 
-
**[[3ucl]] – RhMO + FAD + NADP + cyclohexanone <br />
 
- 
-
*Lysine 6-monooxygenase
 
- 
-
**[[5cqf]] – MO – ''Pseudomonas syringae''<br />
 
-
**[[4d7e]] – NfMO (mutant) + FAD – ''Nocardia farcinica''<br />
 
-
**[[5o8p]] – EaMO + FAD – ''Erwinia amylovora''<br />
 
-
**[[5o8r]] – EaMO + FAD + NADP <br />
 
- 
-
*EDTA monooxygenase
 
- 
-
**[[5dqp]] – MO – ''Chelativorans''<br />
 
- 
-
*Rifampicin monooxygenase or Pentachlorophenol 4-monooxygenase
 
- 
-
**[[5vqb]] – SvMO + FAD – ''Sterptomyces venezuelae''<br />
 
-
**[[6brd]] – SvMO (mutant) + FAD + rifampicin <br />
 
-
**[[5kow]] – NfMO + FAD <br />
 
-
**[[5kox]] – NfMO + FAD + rifampicin <br />
 
- 
-
*3,6-diketocamphane 1,6 monooxygenase
 
- 
-
**[[5aec]] – PpMO <br />
 
-
**[[4uwm]] – PpMO + FMN<br />
 
- 
-
*Lytic polysaccharide monooxygenase
 
- 
-
**[[5tki]], [[5foh]], [[4qi8]] – NcMO-2 + Cu – ''Neurospora crassa''''Italic text''<br />
 
-
**[[5tkh]], [[5tkg]], [[5tkf]], [[4eir]] – NcMO-2 + Cu + O2 <br />
 
-
**[[4eis]] – NcMO-3 + Cu + peroxide <br />
 
-
**[[5iju]] – MO + Cu – ''Bacillus amyloliquefaciens''<br />
 
-
**[[5acj]], [[5aci]], [[5ach]], [[5acg]], [[5acf]] – MO + Cu – ''Lentinus similis''<br />
 
-
**[[4mai]] – moMO + Cu – mold<br />
 
-
**[[4mah]] – moMO + Zn<br />
 
-
**[[5no7]] – MO – ''Pycnoporus cinnabarinus''<br />
 
- 
-
*Peptidyl-glycine alpha-amidating monooxygenase
 
- 
-
**[[5mw0]], [[5wkw]] – rMO <br />
 
-
**[[1yjl]] – rMO (mutant)<br />
 
-
**[[3mib]], [[3mic]], [[3mid]], [[3mie]], [[3mif]], [[3mig]], [[3mih]], [[3mlj]], [[3mlk]], [[3mll]], [[1opm]] – rMO + Cu + Ni <br />
 
-
**[[6ao6]], [[5wja]] – rMO (mutant) + Cu + Ni<br />
 
-
**[[1sdw]] – rMO + Cu + Ni + O2 + threonine derivative<br />
 
-
**[[1yjk]], [[1yip]], [[1phm]] – rMO + Cu<br />
 
-
**[[1yi9]], [[6ay0]], [[6an3]], [[6amp]], [[6alv]], [[6ala]] – rMO (mutant) + Cu<br />
 
-
**[[3fw0]] – rMO + Hg<br />
 
-
**[[3fvz]] – rMO + Zn + Fe<br />
 
- 
-
*Antibiotic biosynthesis monooxygenase
 
- 
-
**[[4hl9]] – MO – ''Rhodospirillum rubrum''<br />
 
-
**[[4dn9]] – MO – ''Chloroflexus aurantiacus''<br />
 
-
**[[2ril]] – MO – ''Shewanella loihica''<br />
 
- 
-
*Monooxygenase
 
- 
-
**[[2i7g]] – MO – ''Agrobacterium tumefaciens''<br />
 
-
**[[5uq4]] – MtMO <br />
 
-
**[[5f5l]] – MiMO – ''Micromonospora'' <br />
 
-
**[[5f5n]] – MiMO + NAD + substrate <br />
 
- 
-
*Monooxygenase TROPB
 
- 
-
**[[6nes]] – TsMO + FAD – ''Talaromyces stipitatus''<br />
 
-
**[[6nev]], [[6neu]] – TsMO (mutant) + FAD <br />
 
-
**[[6net]] – TsMO + FAD + dihydroxy dimethylbenzaldehyde<br />
 
- 
-
*Lactate 2-monooxygenase or lactate oxydase
 
- 
-
**[[6dvi]] – MsLMO + FMN – ''Mycobacterium smegmatis''<br />
 
-
**[[6dvh]] – MsLMO (mutant) + FMN <br />
 
- 
-
*Squalene monooxygenase or squalene epoxidase
 
- 
-
**[[6c6r]], [[6c6p]], [[6c6n]] – hSMO + FAD + inhibitor<br />
 
- 
-
*Dimethyl-sulfide monooxygenase
 
- 
-
**[[6ak1]] – DMOA – ''Hyphomicrobium sulfonivorans''<br />
 
- 
-
*Salicylate 1-monooxygenase or salicylate hydroxylase
 
- 
-
See [[Hydroxylase]]
 
- 
-
'''Methane monooxygenase''' See [[Methane monooxygenase]]
 
- 
-
'''Camphor 5-monooxygenase''' See [[Cytochrome P450]]
 
- 
-
'''Luciferin 4-monooxygenase and Alkanal monooxygenase''' See [[Luciferase]]
 
-
}}
 
== References ==
== References ==

Current revision

Glycosylated lytic polysaccharide monooxygenase complex with Cu(II) (orange) and peroxide (PDB code 5tkh)

Drag the structure with the mouse to rotate

References

  1. ↑ Rudzka K, Moreno DM, Eipper B, Mains R, Estrin DA, Amzel LM. Coordination of peroxide to the Cu(M) center of peptidylglycine alpha-hydroxylating monooxygenase (PHM): structural and computational study. J Biol Inorg Chem. 2012 Dec 18. PMID:23247335 doi:10.1007/s00775-012-0967-z

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Monooxygenase"
Personal tools