Ornithine carbamoyltransferase
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
The biological assembly of OTC is <scene name='57/573976/Cv/6'>homotrimer</scene>. OTC structure contains an <scene name='57/573976/Cv/7'>N-terminal - CP-binding domain and a C-terminal - ornithine binding domain</scene>. OCT <scene name='57/573976/Cv/8'>active site is situated between the two domains</scene><ref>PMID:18062991</ref>. | The biological assembly of OTC is <scene name='57/573976/Cv/6'>homotrimer</scene>. OTC structure contains an <scene name='57/573976/Cv/7'>N-terminal - CP-binding domain and a C-terminal - ornithine binding domain</scene>. OCT <scene name='57/573976/Cv/8'>active site is situated between the two domains</scene><ref>PMID:18062991</ref>. | ||
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| + | ==3D structures of ornithine carbamoyltransferase== | ||
| + | [[Ornithine carbamoyltransferase 3D structures]] | ||
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</StructureSection> | </StructureSection> | ||
==3D structures of ornithine carbamoyltransferase== | ==3D structures of ornithine carbamoyltransferase== | ||
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**[[3upd]], [[4kwt]] – VvOTC – ''Vibrio vulnificus''<br /> | **[[3upd]], [[4kwt]] – VvOTC – ''Vibrio vulnificus''<br /> | ||
**[[3sds]] – OTC – valley fever fungus<br /> | **[[3sds]] – OTC – valley fever fungus<br /> | ||
| + | **[[6ovw]] – OTC – ''Salmonella typhimurium''<br /> | ||
*Catabolic ornithine carbamoyltransferase | *Catabolic ornithine carbamoyltransferase | ||
Revision as of 10:39, 12 November 2019
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3D structures of ornithine carbamoyltransferase
Updated on 12-November-2019
References
- ↑ Murata LB, Schachman HK. Structural similarity between ornithine and aspartate transcarbamoylases of Escherichia coli: characterization of the active site and evidence for an interdomain carboxy-terminal helix in ornithine transcarbamoylase. Protein Sci. 1996 Apr;5(4):709-18. PMID:8845761 doi:http://dx.doi.org/10.1002/pro.5560050416
- ↑ Storkanova G, Vlaskova H, Chuzhanova N, Zeman J, Stranecky V, Majer F, Peskova K, Luksan O, Jirsa M, Hrebicek M, Dvorakova L. Ornithine carbamoyltransferase deficiency: molecular characterization of 29 families. Clin Genet. 2013 Dec;84(6):552-9. doi: 10.1111/cge.12085. Epub 2013 Feb 7. PMID:23278509 doi:http://dx.doi.org/10.1111/cge.12085
- ↑ Sankaranarayanan R, Cherney MM, Cherney LT, Garen CR, Moradian F, James MN. The crystal structures of ornithine carbamoyltransferase from Mycobacterium tuberculosis and its ternary complex with carbamoyl phosphate and L-norvaline reveal the enzyme's catalytic mechanism. J Mol Biol. 2008 Jan 25;375(4):1052-63. Epub 2007 Nov 19. PMID:18062991 doi:10.1016/j.jmb.2007.11.025
