Pantothenate kinase

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{{STRUCTURE_2f9w| PDB=2f9w | SIZE=400| SCENE= |right|CAPTION=Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]] }}
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<StructureSection load='' size='350' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='52/525168/Cv/1' pspeed='8'>
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'''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis. PanK is regulated by feedback inhibition by CoA and its thioesters. Three types of PanK are known. PanK I found in bacteria; PanK II found mostly in eukaryotes; PanK III found in bacteria and known as CoaX.
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== Function ==
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'''Pantothenate kinase''' (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis<ref>. PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959</ref>.<br />
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==3D structures of pantothenate kinase==
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Three types of PanK are known.<br >
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* '''PanK I''' found in bacteria<br />
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* '''PanK II''' found mostly in eukaryotes<br />
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* '''PanK III''' found in bacteria and known as CoaX.
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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== Disease ==
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Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration<ref>PMID:15911822</ref>.
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[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br />
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== Structural highlights ==
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[[1esn]] - EcPanK + ANP<br />
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<scene name='52/525168/Cv/5'>Pantothenate binds in a buried pocket at the PanK dimer interface</scene><ref>PMID:16905099</ref>.
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[[1sq5]] - EcPanK + ADP + PAU<br />
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*<scene name='52/525168/Cv/6'>Buried pocket at the PanK dimer interface</scene>.
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[[3tqc]] - PanK – ''Coxiella burnetii''
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==PanK I binary complex==
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==3D structures of pantothenate kinase==
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[[Pantothenate kinase 3D structures]]
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[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br />
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[[2zs8]], [[2zsb]] - MtPanK + ADP<br />
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[[3af1]] - MtPanK + GDP <br />
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[[3af2]] - MtPanK + AMPPCP<br />
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[[3af4]] - MtPanK + GMPPCP<br />
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[[2zsd]] - MtPanK + CoA<br />
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[[3avo]] - MtPanK + PAU<br />
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[[3avp]], [[3avq]] - MtPanK + PAU derivative<br />
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[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br />
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[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br />
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==PanK I ternary complex==
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[[2zs9]] - MtPanK + ADP + PAU<br />
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[[2zse]] - MtPanK + AMPPCP + PAU<br />
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[[3af3]] - MtPanK + GMPPCP + PAU<br />
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[[2zsf]] - MtPanK + ADP + ATP<br />
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[[2zsa]] - MtPanK + ADP + PPT<BR />
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[[3aez]] - MtPanK + GDP + PPT<BR />
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[[3af0]] - MtPanK + GDP + PAU<br />
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[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br />
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[[4gi7]] – KpPanK + ADP + pantothenate analog<br />
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===PanK II===
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[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br />
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[[4nb4]] - SaPanK + ADP + pantothenamide<br />
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===PanK III===
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[[2gtd]] - TmPanK – ''Thermotoga maritima''<br />
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[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br />
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[[2h3g]] - PanK – ''Bacillus anthracis''<br />
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[[3djc]] - PanK – ''Legionella pneumophila''<br />
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[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br />
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==PanK III binary complex==
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[[2f9w]] - PaPanK + PAU<br />
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[[3bex]] - TmPanK + PAU<br />
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[[3bf3]] - TmPanK + PPT<BR />
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==PanK III ternary complex==
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[[3bf1]] - TmPanK + ADP + PAU<br />
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[[4o5f]] - BtPanK + ADP + PAU <br />
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===Human PanK===
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[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br />
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</StructureSection>
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[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br />
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[[3sms]] – hPanK 3 + PAU analog
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, 2f9w

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References

  1. ↑ . PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959
  2. ↑ Pellecchia MT, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24;64(10):1810-2. PMID:15911822 doi:http://dx.doi.org/10.1212/01.WNL.0000161843.52641.EC
  3. ↑ Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R. Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure. 2006 Aug;14(8):1251-61. PMID:16905099 doi:10.1016/j.str.2006.06.008

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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