Pantothenate kinase

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<StructureSection load='2f9w' size='450' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='52/525168/Cv/1' pspeed='8'>
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<StructureSection load='' size='350' side='right' caption='Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, [[2f9w]]' scene='52/525168/Cv/1' pspeed='8'>
== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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<scene name='52/525168/Cv/3'>Pantothenate binds in a buried pocket at the PanK dimer interface</scene><ref>PMID:16905099</ref>.
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<scene name='52/525168/Cv/5'>Pantothenate binds in a buried pocket at the PanK dimer interface</scene><ref>PMID:16905099</ref>.
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*<scene name='52/525168/Cv/4'>Buried pocket at the PanK dimer interface</scene>.
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*<scene name='52/525168/Cv/6'>Buried pocket at the PanK dimer interface</scene>.
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</StructureSection>
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==3D structures of pantothenate kinase==
==3D structures of pantothenate kinase==
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[[Pantothenate kinase 3D structures]]
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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</StructureSection>
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*'''PanK I'''
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**[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br />
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**[[1esn]] - EcPanK + ANP<br />
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**[[1sq5]] - EcPanK + ADP + PAU<br />
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**[[3tqc]] - PanK – ''Coxiella burnetii''
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*PanK I binary complex
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**[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative – ''Mycobacterium tuberculosis''<br />
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**[[2zs8]], [[2zsb]] - MtPanK + ADP<br />
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**[[3af1]] - MtPanK + GDP <br />
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**[[3af2]] - MtPanK + AMPPCP<br />
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**[[3af4]] - MtPanK + GMPPCP<br />
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**[[2zsd]] - MtPanK + CoA<br />
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**[[3avo]] - MtPanK + PAU<br />
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**[[3avp]], [[3avq]] - MtPanK + PAU derivative<br />
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**[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br />
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**[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br />
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*PanK I ternary complex
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**[[2zs9]] - MtPanK + ADP + PAU<br />
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**[[2zse]] - MtPanK + AMPPCP + PAU<br />
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**[[3af3]] - MtPanK + GMPPCP + PAU<br />
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**[[2zsf]] - MtPanK + ADP + ATP<br />
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**[[2zsa]] - MtPanK + ADP + PPT<BR />
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**[[3aez]] - MtPanK + GDP + PPT<BR />
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**[[3af0]] - MtPanK + GDP + PAU<br />
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**[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br />
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**[[4gi7]] – KpPanK + ADP + pantothenate analog<br />
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*'''PanK II'''
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**[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br />
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**[[4nb4]], [[4m7x]], [[4m7y]], [[5elz]], [[5jic]] - SaPanK + ADP + pantothenate derivative<br />
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*'''PanK III'''
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**[[2gtd]] - TmPanK – ''Thermotoga maritima''<br />
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**[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br />
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**[[2h3g]] - PanK – ''Bacillus anthracis''<br />
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**[[3djc]] - PanK – ''Legionella pneumophila''<br />
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**[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br />
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*PanK III binary complex
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**[[2f9w]] - PaPanK + PAU<br />
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**[[3bex]] - TmPanK + PAU<br />
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**[[3bf3]] - TmPanK + PPT<BR />
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*PanK III higher complexes
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**[[3bf1]] - TmPanK + ADP + PAU<br />
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**[[4o5f]] - BtPanK + ADP + PAU <br />
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**[[5b8h]] - BtPanK + ADP + PAU + imidodiphosphate<br />
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*'''Human PanK'''
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**[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br />
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**[[5e26]] - hPanK 2 + ADP + PAU <br />
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**[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br />
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**[[3sms]] – hPanK 3 + PAU analog<br />
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**[[5kpt]] - hPanK 3 + AMPPNP <br />
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**[[5kq8]] - hPanK 3 + AMPPN <br />
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**[[5kpr]] - hPanK 3 + AMPPNP + PAU <br />
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**[[5kpz]] - hPanK 3 + ADP + PAU <br />
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**[[5kqd]] - hPanK 3 + palmitoyl-CoA <br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Pantothenate kinase III dimer complex with pantothenate, glycerol and ethane diol, 2f9w

Drag the structure with the mouse to rotate

References

  1. ↑ . PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959
  2. ↑ Pellecchia MT, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24;64(10):1810-2. PMID:15911822 doi:http://dx.doi.org/10.1212/01.WNL.0000161843.52641.EC
  3. ↑ Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R. Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure. 2006 Aug;14(8):1251-61. PMID:16905099 doi:10.1016/j.str.2006.06.008

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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