Pantothenate kinase
From Proteopedia
(Difference between revisions)
| Line 20: | Line 20: | ||
</StructureSection> | </StructureSection> | ||
| - | ==3D structures of pantothenate kinase== | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | *'''PanK I''' | ||
| - | |||
| - | **[[1esm]] – EcPanK + CoA – ''Escherichia coli''<br /> | ||
| - | **[[1esn]] - EcPanK + ANP<br /> | ||
| - | **[[1sq5]] - EcPanK + ADP + PAU<br /> | ||
| - | **[[3tqc]] - PanK – ''Coxiella burnetii''<br /> | ||
| - | **[[5xlv]] - MtPanK – ''Mycobacterium tuberculosis''<br /> | ||
| - | **[[5xlw]], [[5xmb]] - MtPanK (mutant)<br /> | ||
| - | |||
| - | *PanK I binary complex | ||
| - | |||
| - | **[[2ges]], [[2get]], [[2zs7]], [[2geu]], [[2gev]] - MtPanK + CoA derivative <br /> | ||
| - | **[[2zs8]], [[2zsb]] - MtPanK + ADP<br /> | ||
| - | **[[3af1]] - MtPanK + GDP <br /> | ||
| - | **[[3af2]] - MtPanK + AMPPCP<br /> | ||
| - | **[[3af4]] - MtPanK + GMPPCP<br /> | ||
| - | **[[2zsd]] - MtPanK + CoA<br /> | ||
| - | **[[3avo]] - MtPanK + PAU<br /> | ||
| - | **[[3avp]], [[3avq]] - MtPanK + PAU derivative<br /> | ||
| - | **[[4bfs]], [[4bft]], [[4bfu]], [[4bfv]], [[4bfw]], [[4bfx]] - MtPanK + triazole inhibitor<br /> | ||
| - | **[[4bfy]], [[4bfz]] - MtPanK + biaryl inhibitor<br /> | ||
| - | |||
| - | *PanK I ternary complex | ||
| - | |||
| - | **[[2zs9]] - MtPanK + ADP + PAU<br /> | ||
| - | **[[2zse]] - MtPanK + AMPPCP + PAU<br /> | ||
| - | **[[3af3]] - MtPanK + GMPPCP + PAU<br /> | ||
| - | **[[2zsf]] - MtPanK + ADP + ATP<br /> | ||
| - | **[[2zsa]] - MtPanK + ADP + PPT<BR /> | ||
| - | **[[3aez]] - MtPanK + GDP + PPT<BR /> | ||
| - | **[[3af0]] - MtPanK + GDP + PAU<br /> | ||
| - | **[[4f7w]], [[4ne2]] – KpPanK + ADP + pantothenamide derivative – ''Klebsiella pneumonia''<br /> | ||
| - | **[[4gi7]] – KpPanK + ADP + pantothenate analog<br /> | ||
| - | |||
| - | *'''PanK II''' | ||
| - | |||
| - | **[[2ews]] - SaPanK + ANP – ''Staphylococcus aureus''<br /> | ||
| - | **[[4nb4]], [[4m7x]], [[4m7y]], [[5elz]], [[5jic]], [[6avp]], [[6awi]], [[6awj]], [[6ebv]] - SaPanK + ADP + pantothenate derivative<br /> | ||
| - | **[[6awh]] - SaPanK + ATP + pantothenate derivative<br /> | ||
| - | **[[6awg]] - SaPanK + ADP + ATP + pantothenate derivative<br /> | ||
| - | |||
| - | *'''PanK III''' | ||
| - | |||
| - | **[[2gtd]] - TmPanK – ''Thermotoga maritima''<br /> | ||
| - | **[[2f9t]] – PaPanK – ''Pseudomonas aeruginosa''<br /> | ||
| - | **[[2h3g]] - PanK – ''Bacillus anthracis''<br /> | ||
| - | **[[3djc]] - PanK – ''Legionella pneumophila''<br /> | ||
| - | **[[4o8k]] - BtPanK – ''Burkholderia thailandensis''<br /> | ||
| - | |||
| - | *PanK III binary complex | ||
| - | |||
| - | **[[2f9w]] - PaPanK + PAU<br /> | ||
| - | **[[3bex]] - TmPanK + PAU<br /> | ||
| - | **[[3bf3]] - TmPanK + PPT<BR /> | ||
| - | |||
| - | *PanK III higher complexes | ||
| - | |||
| - | **[[3bf1]] - TmPanK + ADP + PAU<br /> | ||
| - | **[[4o5f]] - BtPanK + ADP + PAU <br /> | ||
| - | **[[5b8h]] - BtPanK + ADP + PAU + imidodiphosphate<br /> | ||
| - | |||
| - | *'''Human PanK''' | ||
| - | |||
| - | **[[2i7n]], [[3smp]] - hPanK 1 α + CoA - human<br /> | ||
| - | **[[5e26]] - hPanK 2 + ADP + PAU <br /> | ||
| - | **[[2i7p]], [[3mk6]] - hPanK 3 + CoA<br /> | ||
| - | **[[3sms]] – hPanK 3 + PAU analog<br /> | ||
| - | **[[5kpt]] - hPanK 3 + AMPPNP <br /> | ||
| - | **[[5kq8]] - hPanK 3 + AMPPN <br /> | ||
| - | **[[5kpr]] - hPanK 3 + AMPPNP + PAU <br /> | ||
| - | **[[5kpz]] - hPanK 3 + ADP + PAU <br /> | ||
| - | **[[5kqd]] - hPanK 3 + palmitoyl-CoA <br /> | ||
| - | **[[6b3v]] - hPanK 3 + ANP + drug <br /> | ||
| - | |||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
| |||||||||||
References
- ↑ . PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959
- ↑ Pellecchia MT, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24;64(10):1810-2. PMID:15911822 doi:http://dx.doi.org/10.1212/01.WNL.0000161843.52641.EC
- ↑ Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R. Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure. 2006 Aug;14(8):1251-61. PMID:16905099 doi:10.1016/j.str.2006.06.008
