Cholinesterase
From Proteopedia
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| - | < | + | <Structure load='' size='350' frame='true' align='right' caption='human acetylcholinesterase complexed with fasciulin [[1b41]]' scene='Cholinesterase/Human_acetylcholinesterase/1' /> |
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[[Cholinesterase]] belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. | [[Cholinesterase]] belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. | ||
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AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form. | AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form. | ||
| - | <Structure load='1b41' size='400' frame='true' align='right' caption='Glycosylated Human acetylcholinesterase complex with fasciculin-II, [[1b41]]'/> | ||
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| - | <scene name='Cholinesterase/Human_acetylcholinesterase/1'> | ||
Pseudocholinesterase (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver. | Pseudocholinesterase (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver. | ||
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The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly. | The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly. | ||
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Current revision
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Cholinesterase belong to the serine hydrolase family of proteins. They catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation.
They are mainly of two types, namely acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). AChE (EC 3.1.1.7), also known as RBC cholinesterase, erythrocyte cholinesterase, or (most formally) acetylcholine acetylhydrolase, found primarily in the blood and neural synapses. Acetylcholinesterase exists in multiple molecular forms. In the mammalian brain the majority of AChE occurs as a tetrameric, G4 form with much smaller amounts of a monomeric G1 (4S) form.
Pseudocholinesterase (BChE or BuChE), also known as plasma cholinesterase, butyrylcholinesterase, or (most formally) acylcholine acylhydrolase, found primarily in the liver.
The difference between the two types of cholinesterase has to do with their respective preferences for substrates: the former hydrolyses acetylcholine more quickly; the latter hydrolyses butyrylcholine more quickly.
</StructureSection>
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Lakshmi Venkatachalam, Alexander Berchansky
