126d
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:126d.gif|left|200px]] | [[Image:126d.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_126d", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_126d| PDB=126d | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''CRYSTAL STRUCTURE OF CATGGCCATG AND ITS IMPLICATIONS FOR A-TRACT BENDING MODELS''' | '''CRYSTAL STRUCTURE OF CATGGCCATG AND ITS IMPLICATIONS FOR A-TRACT BENDING MODELS''' | ||
| Line 19: | Line 16: | ||
==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=126D OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of CATGGCCATG and its implications for A-tract bending models., Goodsell DS, Kopka ML, Cascio D, Dickerson RE, Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2930-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8464909 8464909] | Crystal structure of CATGGCCATG and its implications for A-tract bending models., Goodsell DS, Kopka ML, Cascio D, Dickerson RE, Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2930-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8464909 8464909] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Cascio, D.]] | [[Category: Cascio, D.]] | ||
[[Category: Dickerson, R E.]] | [[Category: Dickerson, R E.]] | ||
[[Category: Goodsell, D S.]] | [[Category: Goodsell, D S.]] | ||
[[Category: Kopka, M L.]] | [[Category: Kopka, M L.]] | ||
| - | [[Category: | + | [[Category: B-dna]] |
| - | [[Category: | + | [[Category: Double helix]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:28:00 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 06:28, 2 May 2008
CRYSTAL STRUCTURE OF CATGGCCATG AND ITS IMPLICATIONS FOR A-TRACT BENDING MODELS
Overview
The single-crystal x-ray analysis of orthorhombic CATGGCCATG has revealed a previously unrecognized mode of intrinsic bending in DNA. The decamer shows a smooth bend of 23 degrees over the central four base pairs, caused by preferential stacking interactions at guanine bases. The bend is produced by a roll of base pairs along their long axes, in a direction that compresses the wide major groove of the double helix. This major-groove-compressing bend at GGC, plus the abundant crystallographic evidence that runs of successive adenine bases (A-tracts) are straight and unbent, requires rethinking of the models most commonly invoked to explain A-tract bending. A decade of excellent experimental work involving gel migration experiments, cyclization kinetics, and nucleosome phasing has clearly established that introduction of short A-tracts into a general DNA sequence in synchrony with the natural repeat of the helix leads to bending. But it does not logically and inevitably follow that the actual bending is to be found within these introduced A-tracts or even at junctions with general-sequence B-DNA.
About this Structure
Full crystallographic information is available from OCA.
Reference
Crystal structure of CATGGCCATG and its implications for A-tract bending models., Goodsell DS, Kopka ML, Cascio D, Dickerson RE, Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2930-4. PMID:8464909 Page seeded by OCA on Fri May 2 09:28:00 2008
