165d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:165d.jpg|left|200px]]
[[Image:165d.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 165d |SIZE=350|CAPTION= <scene name='initialview01'>165d</scene>, resolution 1.550&Aring;
+
The line below this paragraph, containing "STRUCTURE_165d", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BRU:5-BROMO-2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=RHD:RHODIUM+HEXAMINE+ION'>RHD</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_165d| PDB=165d | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=165d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=165d OCA], [http://www.ebi.ac.uk/pdbsum/165d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=165d RCSB]</span>
+
-
}}
+
'''THE STRUCTURE OF A MISPAIRED RNA DOUBLE HELIX AT 1.6 ANGSTROMS RESOLUTION AND IMPLICATIONS FOR THE PREDICTION OF RNA SECONDARY STRUCTURE'''
'''THE STRUCTURE OF A MISPAIRED RNA DOUBLE HELIX AT 1.6 ANGSTROMS RESOLUTION AND IMPLICATIONS FOR THE PREDICTION OF RNA SECONDARY STRUCTURE'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
165D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=165D OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=165D OCA].
==Reference==
==Reference==
Structure of a mispaired RNA double helix at 1.6-A resolution and implications for the prediction of RNA secondary structure., Cruse WB, Saludjian P, Biala E, Strazewski P, Prange T, Kennard O, Proc Natl Acad Sci U S A. 1994 May 10;91(10):4160-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7514296 7514296]
Structure of a mispaired RNA double helix at 1.6-A resolution and implications for the prediction of RNA secondary structure., Cruse WB, Saludjian P, Biala E, Strazewski P, Prange T, Kennard O, Proc Natl Acad Sci U S A. 1994 May 10;91(10):4160-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7514296 7514296]
-
[[Category: Protein complex]]
 
[[Category: Biala, E.]]
[[Category: Biala, E.]]
[[Category: Cruse, W.]]
[[Category: Cruse, W.]]
Line 30: Line 26:
[[Category: Saludjian, P.]]
[[Category: Saludjian, P.]]
[[Category: Strazewski, P.]]
[[Category: Strazewski, P.]]
-
[[Category: a-dna/rna]]
+
[[Category: A-dna/rna]]
-
[[Category: double helix]]
+
[[Category: Double helix]]
-
[[Category: mismatched]]
+
[[Category: Mismatched]]
-
[[Category: modified]]
+
[[Category: Modified]]
-
[[Category: overhanging base]]
+
[[Category: Overhanging base]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:32:07 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:28:48 2008''
+

Revision as of 06:32, 2 May 2008

Image:165d.jpg

Template:STRUCTURE 165d

THE STRUCTURE OF A MISPAIRED RNA DOUBLE HELIX AT 1.6 ANGSTROMS RESOLUTION AND IMPLICATIONS FOR THE PREDICTION OF RNA SECONDARY STRUCTURE


Overview

The nonamer r(GCUUCGGC)dBrU, where dBrU is 5-bromo-2'-deoxyuridine, contains the tetraloop sequence UUCG. It crystallizes in the presence of Rh(NH3)6Cl3. In solution the oligomer is expected to form a hairpin loop but the x-ray structure analysis, to a resolution of 1.6 A, indicates an eight-base-pair A-RNA duplex containing a central block of two G.U and two C.U pairs. Self-pairs which approximate to Watson-Crick geometry are also formed in the extended crystal structure between symmetry-related BrU residues and are part of infinite double-helical stacks. The G.U pair is a wobble base pair analogous to the G.T pair found in DNA fragments. The C.U mismatch involves one hydrogen-bonded contact between the bases and a bridging water molecule which ensures a good fit of the base pair in the RNA helix. The BrU.BrU pair is held by two hydrogen bonds in an orientation which is compatible with duplex geometry. The structure observed within the crystal has some parallels with the structure of globular RNAs, and the presence of stable, noncanonical base pairs has implications for the prediction of RNA secondary structure.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of a mispaired RNA double helix at 1.6-A resolution and implications for the prediction of RNA secondary structure., Cruse WB, Saludjian P, Biala E, Strazewski P, Prange T, Kennard O, Proc Natl Acad Sci U S A. 1994 May 10;91(10):4160-4. PMID:7514296 Page seeded by OCA on Fri May 2 09:32:07 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/165d"
Personal tools