Plasminogen

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*<scene name='46/465445/Cv/15'>Cl ion coordination site III</scene>.
*<scene name='46/465445/Cv/15'>Cl ion coordination site III</scene>.
*<scene name='46/465445/Cv/16'>Cl ion coordination site IV</scene>.
*<scene name='46/465445/Cv/16'>Cl ion coordination site IV</scene>.
 +
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== 3D Structures of plasminogen ==
 +
[[Plasminogen 3D structures]]
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</StructureSection>
</StructureSection>
== 3D Structures of plasminogen ==
== 3D Structures of plasminogen ==
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**[[1b2i]] - hPLG kringle 2 (mutant) – NMR<BR />
**[[1b2i]] - hPLG kringle 2 (mutant) – NMR<BR />
**[[1i5k]] - hPLG kringle 2 (mutant) + M2 protein peptide<BR />
**[[1i5k]] - hPLG kringle 2 (mutant) + M2 protein peptide<BR />
 +
**[[6dcm]] - hPLG kringle 2 + aminocaproic acid<br />
*Plasminogen kringle 3 resides 272-354
*Plasminogen kringle 3 resides 272-354
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**[[1qrz]], [[1ddj]], [[1rjx]] – hPLG catalytic domain (mutant)<br />
**[[1qrz]], [[1ddj]], [[1rjx]] – hPLG catalytic domain (mutant)<br />
-
**[[1l4d]], [[1l4z]] - hPLG catalytic domain (mutant) + streptokinase α domain
+
**[[1l4d]], [[1l4z]] - hPLG catalytic domain (mutant) + streptokinase α domain<br />
 +
**[[6d3x]], [[6d3y]], [[6d3z]], [[6d40]] - hPLG catalytic domain + trypsin inhibitor 1<br />
*Plasmin
*Plasmin

Revision as of 09:06, 24 November 2019

Human glycosylated plasminogen complex with acetate, bicarbonate, K+ (purple) and Cl- (green) ions (PDB entry 4dur)

Drag the structure with the mouse to rotate

3D Structures of plasminogen

Updated on 24-November-2019

References

  1. Goldenberg DT, Giblin FJ, Cheng M, Chintala SK, Trese MT, Drenser KA, Ruby AJ. Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab (Avastin) in rabbit eyes. Retina. 2011 Feb;31(2):393-400. doi: 10.1097/IAE.0b013e3181e586b2. PMID:21099453 doi:http://dx.doi.org/10.1097/IAE.0b013e3181e586b2
  2. Mehta R, Shapiro AD. Plasminogen deficiency. Haemophilia. 2008 Nov;14(6):1261-8. doi: 10.1111/j.1365-2516.2008.01825.x. PMID:19141167 doi:http://dx.doi.org/10.1111/j.1365-2516.2008.01825.x
  3. Law RH, Caradoc-Davies T, Cowieson N, Horvath AJ, Quek AJ, Encarnacao JA, Steer D, Cowan A, Zhang Q, Lu BG, Pike RN, Smith AI, Coughlin PB, Whisstock JC. The X-ray crystal structure of full-length human plasminogen. Cell Rep. 2012 Mar 29;1(3):185-90. doi: 10.1016/j.celrep.2012.02.012. Epub 2012, Mar 8. PMID:22832192 doi:10.1016/j.celrep.2012.02.012

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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