Pre-mRNA-splicing factor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain, 3e9l }} '''Pre-mRNA-splicing factors (Prp)''' are the proteins whi...)
Current revision (09:17, 27 November 2019) (edit) (undo)
 
(34 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3e9l| PDB=3e9l | SIZE=400| SCENE= |right|CAPTION=Human pre-mRNA-splicing factor 8 endonuclease domain, [[3e9l]] }}
+
<StructureSection load='' size='350' side='right' caption='Yeast pre-mRNA-splicing factor 8 (green) complex with AAR2 (cyan) (PDB entry [[3zef]])' scene='46/462200/Cv/1'>
 +
__TOC__
 +
== Function ==
 +
'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing<ref>PMID:10394358</ref>.
-
'''Pre-mRNA-splicing factors (Prp)''' are the proteins which associate with mRNA at its various splicing sites to produce alternative splicing.
+
*'''Prp3b''' is part of the U2 small nuclear ribonucleoproteins complex (U2 snRNP)<br />
 +
*'''Prp8''' functions as a scaffold which mediates the ordered assembly of spliceosomal proteins and snRNAs. For details see [[Prp8]]<br />
 +
*'''Prp18''' and '''Bud31''' are essential for the catalytic step in pre-mRNA splicing process.<br />
 +
*'''snRNA-associated-splicing factor 24''' binds preferentially to the U4/U6 hybrid snRNAs. For details see [[Prp24]]<br />
 +
*For '''Prp19''' see [[Prp19]]<br />
 +
*For '''Prp20''' see [[Srp20-Human Alternative Splicing Factor]]<br />
 +
*'''Prp31''' functions in forming the U4/U5-U6 tri-snRNP.<br />
 +
*For '''Prp40''' see [[Prp40]].<br />
 +
*'''Prpcwc2''' is a yeast splicing factor which plays a role in the generation of a functional splicing center '''Prp RBM22''' is the human homolog of Prpcwc2.<br />
 +
*'''Prpcwc26''' or '''Bud13''' belongs to the pre-mRNA retention and splicing complex RES.<br />
-
{{TOC limit|limit=2}}
+
== Disease ==
 +
Mutations in Prp8 and Prp31 cause retinitis pigmentosa<ref>PMID:11468273</ref>.
 +
 
 +
== Structural highlights ==
 +
<scene name='46/462200/Cv/3'>Prp8 is a multi-domain protein containing an RNA-binding domain and a Jab1/MPN domain</scene>.
== 3D Structures of pre-mRNA splicing factors ==
== 3D Structures of pre-mRNA splicing factors ==
 +
[[Pre-mRNA splicing factors 3D structures]]
 +
 +
</StructureSection>
 +
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Yeast pre-mRNA-splicing factor 8 (green) complex with AAR2 (cyan) (PDB entry 3zef)

Drag the structure with the mouse to rotate

References

  1. ↑ Misteli T, Spector DL. RNA polymerase II targets pre-mRNA splicing factors to transcription sites in vivo. Mol Cell. 1999 Jun;3(6):697-705. PMID:10394358
  2. ↑ McKie AB, McHale JC, Keen TJ, Tarttelin EE, Goliath R, van Lith-Verhoeven JJ, Greenberg J, Ramesar RS, Hoyng CB, Cremers FP, Mackey DA, Bhattacharya SS, Bird AC, Markham AF, Inglehearn CF. Mutations in the pre-mRNA splicing factor gene PRPC8 in autosomal dominant retinitis pigmentosa (RP13). Hum Mol Genet. 2001 Jul 15;10(15):1555-62. PMID:11468273

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Pre-mRNA-splicing_factor"
Personal tools